Role of calcium, glutamate and NMDA in major depression and therapeutic application

Major depression is a common, recurrent mental illness that affects millions of people worldwide. Recently, a unique fast neuroprotective and antidepressant treatment effect has been observed by ketamine, which acts via the glutamatergic system. Hence, a steady accumulation of evidence supporting a...

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Veröffentlicht in:	Progress in neuro-psychopharmacology & biological psychiatry 2016-01, Vol.64, p.325-333
Hauptverfasser:	Deutschenbaur, Lorenz, Beck, Johannes, Kiyhankhadiv, Anna, Mühlhauser, Markus, Borgwardt, Stefan, Walter, Marc, Hasler, Gregor, Sollberger, Daniel, Lang, Undine E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use BDNF calcium Calcium - metabolism depression Depressive Disorder, Major - drug therapy Depressive Disorder, Major - metabolism Glutamic Acid - metabolism GSK3 Humans ketamine mTOR N-Methylaspartate - metabolism Neurogenesis - drug effects Neurogenesis - physiology Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Neurotransmitter Agents - pharmacology Neurotransmitter Agents - therapeutic use NMDA PI3K
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