Vancomycin: A History
Vancomycin became available for clinical use >50 years ago but was soon discarded in favor of other antibiotics that were deemed to be more efficacious and less toxic. The advent of pseudomembranous enterocolitis, coupled with the spread of methicillin-resistant Staphylococcus aureus, led to a re...
Gespeichert in:
| Veröffentlicht in: | Clinical infectious diseases 2006-01, Vol.42 (Supplement-1), p.S5-S12 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | S12 |
|---|---|
| container_issue | Supplement-1 |
| container_start_page | S5 |
| container_title | Clinical infectious diseases |
| container_volume | 42 |
| creator | Levine, Donald P |
| description | Vancomycin became available for clinical use >50 years ago but was soon discarded in favor of other antibiotics that were deemed to be more efficacious and less toxic. The advent of pseudomembranous enterocolitis, coupled with the spread of methicillin-resistant Staphylococcus aureus, led to a resurgence in the use of vancomycin. Almost immediately, concerns arose with regard to its therapeutic utility. In addition, resistance to vancomycin developed, first in enterococci and later in staphylococci. Several types of resistance have now been identified, each with a unique effect on infections treated with vancomycin. Recent studies have rekindled interest in the best way to administer the antibiotic. The findings of future studies may result in a return to measuring levels of vancomycin in serum, to assure a successful therapeutic outcome. |
| doi_str_mv | 10.1086/491709 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_17103219</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>4484539</jstor_id><sourcerecordid>4484539</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-61e36174fd9dfca9eeb250f1495de0c2c0ff7e461d85ad373854980f8d790b1e3</originalsourceid><addsrcrecordid>eNpdkE1LAzEQhoMoVqvevIkUD95WM5tvb6VoqxZE0CpewjabwNbubk26YP-9KVta8DQD7zMvw4PQGeAbwJLfUgUCqz10BIyIhDMF-3HHTCZUEtlBxyHMMAaQmB2iDnCSEkjxETqfZJWpy5UpqrtevzcqwrL2qxN04LJ5sKeb2UXvD_dvg1Eyfhk-DvrjxNCULxMOlnAQ1OUqdyZT1k5Thh1QxXKLTWqwc8JSDrlkWU4EkYwqiZ3MhcLTeNxF123vwtc_jQ1LXRbB2Pk8q2zdBA0CMElBRfDqHzirG1_F33SMFVdCwK7N-DoEb51e-KLM_EoD1mtLurUUwctNWzMtbb7DNloicNECs7WObU6ppIys75M2jrbs7zbO_LfmggimR59fOv0YPj-J14kekz_SsXZO</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219969771</pqid></control><display><type>article</type><title>Vancomycin: A History</title><source>Jstor Complete Legacy</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Levine, Donald P</creator><creatorcontrib>Levine, Donald P</creatorcontrib><description>Vancomycin became available for clinical use >50 years ago but was soon discarded in favor of other antibiotics that were deemed to be more efficacious and less toxic. The advent of pseudomembranous enterocolitis, coupled with the spread of methicillin-resistant Staphylococcus aureus, led to a resurgence in the use of vancomycin. Almost immediately, concerns arose with regard to its therapeutic utility. In addition, resistance to vancomycin developed, first in enterococci and later in staphylococci. Several types of resistance have now been identified, each with a unique effect on infections treated with vancomycin. Recent studies have rekindled interest in the best way to administer the antibiotic. The findings of future studies may result in a return to measuring levels of vancomycin in serum, to assure a successful therapeutic outcome.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/491709</identifier><identifier>PMID: 16323120</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Anti-Bacterial Agents - history ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Bacteremia ; Bacteria ; Disease control ; Dosage ; Drugs ; Endocarditis ; Enterococcus - drug effects ; Gene Transfer, Horizontal - drug effects ; History of medicine ; History, 20th Century ; History, 21st Century ; Humans ; Infections ; Internships ; Medical treatment ; Nephrotoxicity ; Organisms ; Patients ; Staphylococcus ; Staphylococcus aureus ; Staphylococcus aureus - drug effects ; Toxicity ; Vancomycin - history ; Vancomycin - pharmacology ; Vancomycin - therapeutic use ; Vancomycin Resistance - genetics</subject><ispartof>Clinical infectious diseases, 2006-01, Vol.42 (Supplement-1), p.S5-S12</ispartof><rights>Copyright 2006 The Infectious Diseases Society of America</rights><rights>Copyright University of Chicago, acting through its Press Jan 1, 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-61e36174fd9dfca9eeb250f1495de0c2c0ff7e461d85ad373854980f8d790b1e3</citedby><cites>FETCH-LOGICAL-c426t-61e36174fd9dfca9eeb250f1495de0c2c0ff7e461d85ad373854980f8d790b1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4484539$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4484539$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16323120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Levine, Donald P</creatorcontrib><title>Vancomycin: A History</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><description>Vancomycin became available for clinical use >50 years ago but was soon discarded in favor of other antibiotics that were deemed to be more efficacious and less toxic. The advent of pseudomembranous enterocolitis, coupled with the spread of methicillin-resistant Staphylococcus aureus, led to a resurgence in the use of vancomycin. Almost immediately, concerns arose with regard to its therapeutic utility. In addition, resistance to vancomycin developed, first in enterococci and later in staphylococci. Several types of resistance have now been identified, each with a unique effect on infections treated with vancomycin. Recent studies have rekindled interest in the best way to administer the antibiotic. The findings of future studies may result in a return to measuring levels of vancomycin in serum, to assure a successful therapeutic outcome.</description><subject>Anti-Bacterial Agents - history</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Bacteremia</subject><subject>Bacteria</subject><subject>Disease control</subject><subject>Dosage</subject><subject>Drugs</subject><subject>Endocarditis</subject><subject>Enterococcus - drug effects</subject><subject>Gene Transfer, Horizontal - drug effects</subject><subject>History of medicine</subject><subject>History, 20th Century</subject><subject>History, 21st Century</subject><subject>Humans</subject><subject>Infections</subject><subject>Internships</subject><subject>Medical treatment</subject><subject>Nephrotoxicity</subject><subject>Organisms</subject><subject>Patients</subject><subject>Staphylococcus</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Toxicity</subject><subject>Vancomycin - history</subject><subject>Vancomycin - pharmacology</subject><subject>Vancomycin - therapeutic use</subject><subject>Vancomycin Resistance - genetics</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1LAzEQhoMoVqvevIkUD95WM5tvb6VoqxZE0CpewjabwNbubk26YP-9KVta8DQD7zMvw4PQGeAbwJLfUgUCqz10BIyIhDMF-3HHTCZUEtlBxyHMMAaQmB2iDnCSEkjxETqfZJWpy5UpqrtevzcqwrL2qxN04LJ5sKeb2UXvD_dvg1Eyfhk-DvrjxNCULxMOlnAQ1OUqdyZT1k5Thh1QxXKLTWqwc8JSDrlkWU4EkYwqiZ3MhcLTeNxF123vwtc_jQ1LXRbB2Pk8q2zdBA0CMElBRfDqHzirG1_F33SMFVdCwK7N-DoEb51e-KLM_EoD1mtLurUUwctNWzMtbb7DNloicNECs7WObU6ppIys75M2jrbs7zbO_LfmggimR59fOv0YPj-J14kekz_SsXZO</recordid><startdate>20060101</startdate><enddate>20060101</enddate><creator>Levine, Donald P</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T2</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>20060101</creationdate><title>Vancomycin: A History</title><author>Levine, Donald P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-61e36174fd9dfca9eeb250f1495de0c2c0ff7e461d85ad373854980f8d790b1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Anti-Bacterial Agents - history</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotics</topic><topic>Bacteremia</topic><topic>Bacteria</topic><topic>Disease control</topic><topic>Dosage</topic><topic>Drugs</topic><topic>Endocarditis</topic><topic>Enterococcus - drug effects</topic><topic>Gene Transfer, Horizontal - drug effects</topic><topic>History of medicine</topic><topic>History, 20th Century</topic><topic>History, 21st Century</topic><topic>Humans</topic><topic>Infections</topic><topic>Internships</topic><topic>Medical treatment</topic><topic>Nephrotoxicity</topic><topic>Organisms</topic><topic>Patients</topic><topic>Staphylococcus</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Toxicity</topic><topic>Vancomycin - history</topic><topic>Vancomycin - pharmacology</topic><topic>Vancomycin - therapeutic use</topic><topic>Vancomycin Resistance - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levine, Donald P</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levine, Donald P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vancomycin: A History</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clinical Infectious Diseases</addtitle><date>2006-01-01</date><risdate>2006</risdate><volume>42</volume><issue>Supplement-1</issue><spage>S5</spage><epage>S12</epage><pages>S5-S12</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><abstract>Vancomycin became available for clinical use >50 years ago but was soon discarded in favor of other antibiotics that were deemed to be more efficacious and less toxic. The advent of pseudomembranous enterocolitis, coupled with the spread of methicillin-resistant Staphylococcus aureus, led to a resurgence in the use of vancomycin. Almost immediately, concerns arose with regard to its therapeutic utility. In addition, resistance to vancomycin developed, first in enterococci and later in staphylococci. Several types of resistance have now been identified, each with a unique effect on infections treated with vancomycin. Recent studies have rekindled interest in the best way to administer the antibiotic. The findings of future studies may result in a return to measuring levels of vancomycin in serum, to assure a successful therapeutic outcome.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>16323120</pmid><doi>10.1086/491709</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 2006-01, Vol.42 (Supplement-1), p.S5-S12 |
| issn | 1058-4838 1537-6591 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17103219 |
| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Anti-Bacterial Agents - history Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotics Bacteremia Bacteria Disease control Dosage Drugs Endocarditis Enterococcus - drug effects Gene Transfer, Horizontal - drug effects History of medicine History, 20th Century History, 21st Century Humans Infections Internships Medical treatment Nephrotoxicity Organisms Patients Staphylococcus Staphylococcus aureus Staphylococcus aureus - drug effects Toxicity Vancomycin - history Vancomycin - pharmacology Vancomycin - therapeutic use Vancomycin Resistance - genetics |
| title | Vancomycin: A History |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T21%3A40%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vancomycin:%20A%20History&rft.jtitle=Clinical%20infectious%20diseases&rft.au=Levine,%20Donald%20P&rft.date=2006-01-01&rft.volume=42&rft.issue=Supplement-1&rft.spage=S5&rft.epage=S12&rft.pages=S5-S12&rft.issn=1058-4838&rft.eissn=1537-6591&rft_id=info:doi/10.1086/491709&rft_dat=%3Cjstor_proqu%3E4484539%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=219969771&rft_id=info:pmid/16323120&rft_jstor_id=4484539&rfr_iscdi=true |