IL-4 in combination with TGF-beta favors an alternative pathway of Th1 development independent of IL-12

IL-4 was found to be the essential differentiation factor for Th2 cells and simultaneously to be a potent inhibitor of Th1 development that is induced by IFN-gamma and IL-12. Furthermore, it was demonstrated that TGF-beta can also inhibit Thl development. In this work, we demonstrate that polyclonal...

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Veröffentlicht in:	The Journal of immunology (1950) 1998-11, Vol.161 (9), p.4709-4718
Hauptverfasser:	Lingnau, K, Hoehn, P, Kerdine, S, Koelsch, S, Neudoerfl, C, Palm, N, Ruede, E, Schmitt, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - drug effects Dose-Response Relationship, Immunologic Drug Synergism Female Interferon-gamma - biosynthesis Interferon-gamma - physiology Interleukin-12 - pharmacology Interleukin-12 - physiology Interleukin-4 - biosynthesis Interleukin-4 - pharmacology Lymphocyte Activation - drug effects Male Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred DBA Mice, Transgenic Osmolar Concentration Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - immunology Th1 Cells - cytology Th1 Cells - drug effects Th1 Cells - metabolism Th2 Cells - cytology Th2 Cells - drug effects Transforming Growth Factor beta - pharmacology
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