Ugi-derived dehydroalanines as a pivotal template in the diversity oriented synthesis of aza-polyheterocycles
Various readily available, Ugi-derived dehydroalanines were used as pivotal templates to easily and efficiently assemble diverse pharmacologically important polyheterocyclic systems through cascade palladium-catalyzed C-C bond formation processes. Allyl, homoallyl and propargylamine led to the forma...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2015-07, Vol.51 (58), p.11669-11672 |
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| container_issue | 58 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | García-González, Ma Carmen Hernández-Vázquez, Eduardo Gordillo-Cruz, Raúl E Miranda, Luis D |
| description | Various readily available, Ugi-derived dehydroalanines were used as pivotal templates to easily and efficiently assemble diverse pharmacologically important polyheterocyclic systems through cascade palladium-catalyzed C-C bond formation processes. Allyl, homoallyl and propargylamine led to the formation of benzopyrrolizidinones, benzoindolizidinones and pyrazinoisoquinolines, respectively, while benzylamines and o-bromobenzylamines were used as precursors of tetracyclic-fused systems and pyrazionoisoquinolindiones. |
| doi_str_mv | 10.1039/c5cc02927a |
| format | Article |
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| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2015-07, Vol.51 (58), p.11669-11672 |
| issn | 1359-7345 1364-548X |
| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Alanine - analogs & derivatives Alanine - chemistry Benzylamines - chemistry Bonding Carbon-carbon composites Cascades Catalysis Formations Indoles - chemistry Isoquinolines - chemistry Palladium - chemistry Precursors Pyrroles - chemistry Synthesis |
| title | Ugi-derived dehydroalanines as a pivotal template in the diversity oriented synthesis of aza-polyheterocycles |
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