High throughput screening of particle conditioning operations: II. Evaluation of scale-up heuristics with prokaryotically expressed polysaccharide vaccines

ABSTRACT Multivalent polysaccharide conjugate vaccines are typically comprised of several different polysaccharides produced with distinct and complex production processes. Particle conditioning steps, such as precipitation and flocculation, may be used to aid the recovery and purification of such m...

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Veröffentlicht in:	Biotechnology and bioengineering 2015-08, Vol.112 (8), p.1568-1582
Hauptverfasser:	Noyes, Aaron, Huffman, Ben, Berrill, Alex, Merchant, Nick, Godavarti, Ranga, Titchener-Hooker, Nigel, Coffman, Jonathan, Sunasara, Khurram, Mukhopadhyay, Tarit
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Bacterial Vaccines - genetics Bacterial Vaccines - immunology Bacterial Vaccines - isolation & purification Biological Products - immunology Biological Products - isolation & purification Bioreactors - microbiology capsular polysaccharide clarification Clearances Conditioning DOE Flocculating Flocculation Heuristic high throughput process development Impellers Impurities MALS particle conditioning Polysaccharides Polysaccharides, Bacterial - genetics Polysaccharides, Bacterial - immunology Polysaccharides, Bacterial - isolation & purification Precipitation Prokaryotes Proteins purity QbD scalability screening Technology, Pharmaceutical - methods ultra scale-down vaccine Vaccines windows of operation yield
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