Electrochemical Imaging of Dopamine Release from Three-Dimensional-Cultured PC12 Cells Using Large-Scale Integration-Based Amperometric Sensors

In the present study, we used a large-scale integration (LSI)-based amperometric sensor array system, designated Bio-LSI, to image dopamine release from three-dimensional (3D)-cultured PC12 cells (PC12 spheroids). The Bio-LSI device consists of 400 sensor electrodes with a pitch of 250 μm for rapid...

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Veröffentlicht in:	Analytical chemistry (Washington) 2015-06, Vol.87 (12), p.6364-6370
Hauptverfasser:	Abe, Hiroya, Ino, Kosuke, Li, Chen-Zhong, Kanno, Yusuke, Inoue, Kumi Y, Suda, Atsushi, Kunikata, Ryota, Matsudaira, Masahki, Takahashi, Yasufumi, Shiku, Hitoshi, Matsue, Tomokazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Animals Cell Culture Techniques - methods Cells Devices Dopamine Dopamine - analysis Dopamine - secretion Drugs Electrical measurements Electrochemical Techniques - instrumentation Electrochemical Techniques - methods Electrodes Imaging PC12 Cells Rats Sensors Spheroids Spheroids, Cellular - cytology Spheroids, Cellular - secretion
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