Disulfide Cross-Linked Polyurethane Micelles as a Reduction-Triggered Drug Delivery System for Cancer Therapy

Nanoscale carriers that stably load drugs in blood circulation and release the payloads in desirable sites in response to a specific trigger are of great interest for smart drug delivery systems. For this purpose, a novel type of disulfide core cross‐linked micelles, which are facilely fabricated by...

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Veröffentlicht in:	Advanced healthcare materials 2014-05, Vol.3 (5), p.752-760
Hauptverfasser:	Yu, Shuangjiang, Ding, Jianxun, He, Chaoliang, Cao, Yue, Xu, Weiguo, Chen, Xuesi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Biocompatibility Biological and medical sciences Block copolymers Blood circulation Body Weight - drug effects Cancer Cancer therapies cancer therapy Cell Line, Tumor Cell Survival - drug effects Crosslinking Cytotoxicity disulfide cross-linking Disulfides Disulfides - chemistry Doxorubicin Doxorubicin - chemistry Doxorubicin - pharmacokinetics Doxorubicin - pharmacology Drug Carriers - chemistry Drug delivery Drug delivery systems Drug therapy Drugs Glutathione Humans intracellular delivery Medical sciences Mice Mice, Nude Micelles Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Payloads Pharmaceutical industry Polyethylene glycol Polyethylene Glycols - chemistry Polyurethane polyurethane nanocarriers Polyurethane resins Polyurethanes - chemistry Reagents Reducing agents reduction-responsiveness Side effects Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Therapy Toxicity Tumors Xenograft Model Antitumor Assays
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