Bioreducible Carboxymethyl Dextran Nanoparticles for Tumor-Targeted Drug Delivery

Bioreducible carboxymethyl dextran (CMD) derivatives are synthesized by the chemical modification of CMD with lithocholic acid (LCA) through a disulfide linkage. The hydrophobic nature of LCA allows the conjugates (CMD‐SS‐LCAs) to form self‐assembled nanoparticles in aqueous conditions. Depending on...

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Veröffentlicht in:	Advanced healthcare materials 2014-11, Vol.3 (11), p.1829-1838
Hauptverfasser:	Thambi, Thavasyappan, You, Dong Gil, Han, Hwa Seung, Deepagan, V. G., Jeon, Sang Min, Suh, Yung Doug, Choi, Ki Young, Kim, Kwangmeyung, Kwon, Ick Chan, Yi, Gi-Ra, Lee, Jun Young, Lee, Doo Sung, Park, Jae Hyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Biocompatibility Biological and medical sciences bioreducible nanoparticle Cancer carboxymethyl-dextran Cell Line, Tumor Chemical bonds Chemotherapy Cross-disciplinary physics: materials science rheology Dextrans Dextrans - administration & dosage Dextrans - chemistry Disulfides doxorubicin Doxorubicin - administration & dosage Doxorubicin - chemistry Drug Carriers - administration & dosage Drug Carriers - chemistry drug delivery Drug delivery systems Drug Delivery Systems - methods Drugs Exact sciences and technology Glutathione - metabolism Hydrophobic and Hydrophilic Interactions Materials science Medical sciences Mice Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Nanoscale materials and structures: fabrication and characterization Particle Size Pharmacology. Drug treatments Physics Tissue Distribution Tumors
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