Nonendocytic Delivery of Lipoplex Nanoparticles into Living Cells Using Nanochannel Electroporation

The delivery of biomolecules, including siRNAs (≈21 bp) and large plasmids (≈10 kbp), into living cells holds a great promise for therapeutic and research applications. Lipoplex nanoparticles are popular nanocarriers for gene delivery. In conventional transfection methods, the cellular uptake of lip...

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Veröffentlicht in:	Advanced healthcare materials 2014-05, Vol.3 (5), p.682-689
Hauptverfasser:	Boukany, Pouyan E., Wu, Yun, Zhao, Xi, Kwak, Kwang J., Glazer, Piotr J., Leong, Kam, Lee, L. James
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Biological and medical sciences biomedical devices Biomolecules Cell Line, Tumor Cells (biology) Cellular Cricetinae Cricetulus Cytoplasm Devices Electroporation Electroporation - methods Endocytosis Endocytosis - physiology Energy transfer Entrapment Fluorescence resonance energy transfer gene delivery Gene expression Gene silencing Gene transfer Genes Humans lipoplexes Liposomes - administration & dosage Liposomes - chemistry Liposomes - pharmacokinetics Medical sciences Molecular Probe Techniques mRNA Nanochannels nanofluidics Nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Nanoparticles - metabolism Nanostructure Nanotechnology - methods Plasmids Plasmids - administration & dosage Plasmids - chemistry Quantum dots RNA, Small Interfering - administration & dosage RNA, Small Interfering - chemistry RNA, Small Interfering - genetics RNA, Small Interfering - pharmacokinetics siRNA Transfection Transfection - methods Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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