The effect of DNA supercoiling on nucleosome structure and stability

Nucleosomes have to open to allow access to DNA in transcription, replication, and DNA damage repair. Changes in DNA torsional strain (e.g. during transcription elongation) influence the accessibility of nucleosomal DNA. Here we investigated the effect of DNA supercoiling-induced torsional strain on...

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Veröffentlicht in:	Journal of physics. Condensed matter 2015-02, Vol.27 (6), p.064105-7
Hauptverfasser:	Elbel, Tabea, Langowski, Jörg
Format:	Artikel
Sprache:	eng
Schlagworte:	Accessibility atomic force spectroscopy Condensed matter Density Deoxyribonucleic acid DNA, Superhelical - chemistry Elongation Fluorescence fluorescence correlation spectroscopy Fluorescent Dyes - chemistry histone Nucleosomes - chemistry Plasmids - genetics Stability Strain supercoiled DNA
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