Hyperthermia-Induced Drug Delivery from Thermosensitive Liposomes Encapsulated in an Injectable Hydrogel for Local Chemotherapy

A novel drug delivery system, enabling an in situ, thermally triggered drug release is described, consisting of an injectable thermoresponsive chitosan hydrogel containing doxorubicin‐loaded thermosensitive liposomes. The design, fabrication, characterization, and an assessment of in vitro bioactivi...

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Veröffentlicht in:	Advanced healthcare materials 2014-06, Vol.3 (6), p.854-859
Hauptverfasser:	López-Noriega, Adolfo, Hastings, Conn L., Ozbakir, Burcin, O'Donnell, Kathleen E., O'Brien, Fergal J., Storm, Gert, Hennink, Wim E., Duffy, Garry P., Ruiz-Hernández, Eduardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Assessments Biochemistry Biological and medical sciences Cell Line, Tumor Cell Survival - drug effects Chemotherapy Chitosan - chemistry chitosan hydrogels Doxorubicin - chemistry Doxorubicin - metabolism Doxorubicin - pharmacology Drug delivery systems Encapsulation General pharmacology Glycerophosphates - chemistry Humans Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry Hydrogels hyperthermia Liposomes Liposomes - chemistry Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Temperature thermoresponsive Thermosensitive
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Zusammenfassung:	A novel drug delivery system, enabling an in situ, thermally triggered drug release is described, consisting of an injectable thermoresponsive chitosan hydrogel containing doxorubicin‐loaded thermosensitive liposomes. The design, fabrication, characterization, and an assessment of in vitro bioactivity of this formulation is detailed. Combining on‐demand drug delivery with in situ gelation results in a promising candidate for local chemotherapy.
ISSN:	2192-2640 2192-2659
DOI:	10.1002/adhm.201300649