Impact of thymine glycol damage on DNA duplex energetics: Correlations with lesion-induced biochemical and structural consequences

ABSTRACT The magnitude and nature of lesion‐induced energetic perturbations empirically correlate with mutagenicity/cytotoxicity profiles and can be predictive of lesion outcomes during polymerase‐mediated replication in vitro. In this study, we assess the sequence and counterbase‐dependent energeti...

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Veröffentlicht in:	Biopolymers 2015-09, Vol.103 (9), p.491-508
Hauptverfasser:	Minetti, Conceição A. S. A., Remeta, David P., Iden, Charles R., Johnson, Francis, Grollman, Arthur P., Breslauer, Kenneth J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Calorimetry, Differential Scanning Circular Dichroism Correlation Damage differential scanning calorimetry DNA - chemistry DNA damage DNA Damage - genetics Glycols In vitro testing Lesions mismatches Nucleic Acid Conformation Perturbation Replication Thermodynamics thymidine glycol Thymine Thymine - analogs & derivatives Thymine - chemistry thymine glycol
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