Biophysical Interactions of Novel Oleic Acid Conjugate and its Anticancer Potential in HeLa Cells

Novel conjugate 2,6-Diisopropylphenol-Oleic acid (2,6P-OLA) has shown potent anticancer activity on various cancer cell lines (Khan et al. Lipids 47:973–986, 2012 ). In the present study, the protein-or/ and DNA-binding property of 2,6P-OLA was evaluated that could predict its potential toxic effect...

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Veröffentlicht in:	Journal of fluorescence 2015-05, Vol.25 (3), p.519-525
Hauptverfasser:	Khan, Azmat Ali, Alanazi, Amer M., Jabeen, Mumtaz, Pervez, Khalid, Wahab, Rizwan, Abdelhameed, Ali Saber, Chauhan, Arun
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical Chemistry Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects Bacteria Binding Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biomedicine Biophysics Biotechnology Cancer Cattle Cell Proliferation - drug effects Circular Dichroism Conjugates Deoxyribonucleic acid Dichroism DNA - metabolism Fluorescence HeLa Cells Humans Mathematical models Oleic Acid - chemistry Oleic Acid - metabolism Original Paper Protein Binding Serum Albumin - metabolism Spectrometry, Fluorescence Thermodynamics
Online-Zugang:	Volltext
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