Biocompatible Reactive Oxygen Species (ROS)-Responsive Nanoparticles as Superior Drug Delivery Vehicles
A novel reactive oxygen species (ROS)‐responsive nanoplatform can be successfully manufactured from a ROS‐triggerable β‐cyclodextrin material. Extensive in vitro and in vivo studies validate that this nanoscaled system may serve as a new drug delivery vehicle with well‐defined ROS‐sensitivity and su...
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| Veröffentlicht in: | Advanced healthcare materials 2015-01, Vol.4 (1), p.69-76 |
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| container_title | Advanced healthcare materials |
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| creator | Zhang, Dinglin Wei, Yanling Chen, Kai Zhang, Xiangjun Xu, Xiaoqiu Shi, Qing Han, Songling Chen, Xin Gong, Hao Li, Xiaohui Zhang, Jianxiang |
| description | A novel reactive oxygen species (ROS)‐responsive nanoplatform can be successfully manufactured from a ROS‐triggerable β‐cyclodextrin material. Extensive in vitro and in vivo studies validate that this nanoscaled system may serve as a new drug delivery vehicle with well‐defined ROS‐sensitivity and superior biocompatibility. This nanocarrier can be used for ROS‐triggered transport of diverse therapeutics and imaging agents. |
| doi_str_mv | 10.1002/adhm.201400299 |
| format | Article |
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Extensive in vitro and in vivo studies validate that this nanoscaled system may serve as a new drug delivery vehicle with well‐defined ROS‐sensitivity and superior biocompatibility. This nanocarrier can be used for ROS‐triggered transport of diverse therapeutics and imaging agents.</description><identifier>ISSN: 2192-2640</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.201400299</identifier><identifier>PMID: 25147049</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>Animals ; Biocompatibility ; Biocompatible Materials - chemical synthesis ; Biocompatible Materials - chemistry ; Biocompatible Materials - pharmacology ; Biomedical materials ; Cell Line ; Chemical compounds ; cyclodextrin ; Drug Carriers - chemical synthesis ; Drug Carriers - chemistry ; Drug Carriers - pharmacology ; drug delivery ; Drug delivery systems ; Humans ; In vivo testing ; In vivo tests ; Materials Testing ; Mice ; nanomedicine ; Nanoparticles - chemistry ; Nanostructure ; Reactive Oxygen Species - chemistry ; Reactive Oxygen Species - metabolism ; ROS-responsiveness ; tumor targeting ; Vehicles</subject><ispartof>Advanced healthcare materials, 2015-01, Vol.4 (1), p.69-76</ispartof><rights>2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4819-e1a63d7c4ab0f0df67b85ce5375dbf6aefc817240fe874b94d9e5a1a373482b3</citedby><cites>FETCH-LOGICAL-c4819-e1a63d7c4ab0f0df67b85ce5375dbf6aefc817240fe874b94d9e5a1a373482b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadhm.201400299$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadhm.201400299$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25147049$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Dinglin</creatorcontrib><creatorcontrib>Wei, Yanling</creatorcontrib><creatorcontrib>Chen, Kai</creatorcontrib><creatorcontrib>Zhang, Xiangjun</creatorcontrib><creatorcontrib>Xu, Xiaoqiu</creatorcontrib><creatorcontrib>Shi, Qing</creatorcontrib><creatorcontrib>Han, Songling</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Gong, Hao</creatorcontrib><creatorcontrib>Li, Xiaohui</creatorcontrib><creatorcontrib>Zhang, Jianxiang</creatorcontrib><title>Biocompatible Reactive Oxygen Species (ROS)-Responsive Nanoparticles as Superior Drug Delivery Vehicles</title><title>Advanced healthcare materials</title><addtitle>Adv. Healthcare Mater</addtitle><description>A novel reactive oxygen species (ROS)‐responsive nanoplatform can be successfully manufactured from a ROS‐triggerable β‐cyclodextrin material. Extensive in vitro and in vivo studies validate that this nanoscaled system may serve as a new drug delivery vehicle with well‐defined ROS‐sensitivity and superior biocompatibility. This nanocarrier can be used for ROS‐triggered transport of diverse therapeutics and imaging agents.</description><subject>Animals</subject><subject>Biocompatibility</subject><subject>Biocompatible Materials - chemical synthesis</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Biomedical materials</subject><subject>Cell Line</subject><subject>Chemical compounds</subject><subject>cyclodextrin</subject><subject>Drug Carriers - chemical synthesis</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Carriers - pharmacology</subject><subject>drug delivery</subject><subject>Drug delivery systems</subject><subject>Humans</subject><subject>In vivo testing</subject><subject>In vivo tests</subject><subject>Materials Testing</subject><subject>Mice</subject><subject>nanomedicine</subject><subject>Nanoparticles - chemistry</subject><subject>Nanostructure</subject><subject>Reactive Oxygen Species - chemistry</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>ROS-responsiveness</subject><subject>tumor targeting</subject><subject>Vehicles</subject><issn>2192-2640</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFv0zAUxi3ExKZtV44oEpdxSGc7jh0fxwor0taKdgJuluO8dB5JnNkJW__7uXRUiAvv4me93_fp6X0IvSV4QjCm57q6aycUExY_Ur5CR5RImlKey9f7nuFDdBrCPY7Fc8IL8gYd0pwwgZk8QuuP1hnX9nqwZQPJErQZ7C9IFk-bNXTJqgdjISRny8XqQ7qE0LsubOdz3ble-8GaJo51SFZjD946n0z9uE6m0ETKb5JvcPcbOUEHtW4CnL68x-j286fby1l6vbj6cnlxnRpWEJkC0TyrhGG6xDWuai7KIjeQZyKvypprqE1BBGW4hkKwUrJKQq6JzkTGClpmx-hsZ9t79zBCGFRrg4Gm0R24MSgisBRESpJF9P0_6L0bfReXU4QzygqZUxypyY4y3oXgoVa9t632G0Ww2oagtiGofQhR8O7FdixbqPb4n5NHQO6AR9vA5j926mI6u_nbPN1pbRjgaa_V_qfiIt5IfZ9fRfGci6-zQv3IngGrsKIw</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Zhang, Dinglin</creator><creator>Wei, Yanling</creator><creator>Chen, Kai</creator><creator>Zhang, Xiangjun</creator><creator>Xu, Xiaoqiu</creator><creator>Shi, Qing</creator><creator>Han, Songling</creator><creator>Chen, Xin</creator><creator>Gong, Hao</creator><creator>Li, Xiaohui</creator><creator>Zhang, Jianxiang</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T5</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7TO</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope></search><sort><creationdate>20150101</creationdate><title>Biocompatible Reactive Oxygen Species (ROS)-Responsive Nanoparticles as Superior Drug Delivery Vehicles</title><author>Zhang, Dinglin ; 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| subjects | Animals Biocompatibility Biocompatible Materials - chemical synthesis Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biomedical materials Cell Line Chemical compounds cyclodextrin Drug Carriers - chemical synthesis Drug Carriers - chemistry Drug Carriers - pharmacology drug delivery Drug delivery systems Humans In vivo testing In vivo tests Materials Testing Mice nanomedicine Nanoparticles - chemistry Nanostructure Reactive Oxygen Species - chemistry Reactive Oxygen Species - metabolism ROS-responsiveness tumor targeting Vehicles |
| title | Biocompatible Reactive Oxygen Species (ROS)-Responsive Nanoparticles as Superior Drug Delivery Vehicles |
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