Polyomavirus Hominis 1(BK virus) Infection in Prostatic Tissues: Cancer versus Hyperplasia
Polyomavirus hominis 1, better known as BK virus (BKV) infection might be a predisposing factor for prostate cancer (PCa). The aim of this study was to compare the frequency of BK virus infection in pathological specimens of patients with PCa compared to patients with benign prostatic hyperplasia. F...
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| Veröffentlicht in: | Urology journal 2015-09, Vol.12 (4), p.2240-2244 |
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| creator | Taghavi, Afsoon Mohammadi-Torbati, Peyman Kashi, Amir Hossein Rezaee, Hanieh Vaezjalali, Maryam |
| description | Polyomavirus hominis 1, better known as BK virus (BKV) infection might be a predisposing factor for prostate cancer (PCa). The aim of this study was to compare the frequency of BK virus infection in pathological specimens of patients with PCa compared to patients with benign prostatic hyperplasia.
From July 2011 to June 2012, paraffin-embedded tissue blocks of patients with PCa (60 specimens) and also with benign prostatic hyperplasia (60 specimens) were investigated. After DNA purification, existence of virus nucleic acid was assessed by polymerase chain reaction.
Viral DNA was identified in 9 patients (15%) with benign prostatic hyperplasia (BPH) and 17 patients (28%) with PCa (P = .076). In patients with PCa, viral DNA was observed more often in those with lower total Gleason scores (P = .045).
The frequency of BK virus infection in PCa patients was higher than BPH patients. BK virus was more often observed in patients with lower Gleason scores. Less detection of BK virus DNA in overt cancer may prove the activity of the virus which paves the way for tumorigenic transformation at early stages of PCa. |
| format | Article |
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From July 2011 to June 2012, paraffin-embedded tissue blocks of patients with PCa (60 specimens) and also with benign prostatic hyperplasia (60 specimens) were investigated. After DNA purification, existence of virus nucleic acid was assessed by polymerase chain reaction.
Viral DNA was identified in 9 patients (15%) with benign prostatic hyperplasia (BPH) and 17 patients (28%) with PCa (P = .076). In patients with PCa, viral DNA was observed more often in those with lower total Gleason scores (P = .045).
The frequency of BK virus infection in PCa patients was higher than BPH patients. BK virus was more often observed in patients with lower Gleason scores. Less detection of BK virus DNA in overt cancer may prove the activity of the virus which paves the way for tumorigenic transformation at early stages of PCa.</description><identifier>ISSN: 1735-1308</identifier><identifier>EISSN: 1735-546X</identifier><identifier>PMID: 26341765</identifier><language>eng</language><publisher>Iran: Urology and Nephrology Research Center</publisher><subject>Aged ; Aged, 80 and over ; BK Virus - genetics ; DNA, Viral - analysis ; Follow-Up Studies ; Humans ; Incidence ; Iran - epidemiology ; Male ; Middle Aged ; Neoplasm Grading ; Polymerase Chain Reaction ; Polyomavirus Infections - epidemiology ; Polyomavirus Infections - virology ; Prostate - pathology ; Prostate - virology ; Prostatic Hyperplasia - epidemiology ; Prostatic Hyperplasia - pathology ; Prostatic Hyperplasia - virology ; Prostatic Neoplasms - epidemiology ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - virology ; Retrospective Studies ; Risk Factors ; Tumor Virus Infections - epidemiology ; Tumor Virus Infections - virology</subject><ispartof>Urology journal, 2015-09, Vol.12 (4), p.2240-2244</ispartof><rights>Copyright Urology and Nephrology Research Center Jul/Aug 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26341765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taghavi, Afsoon</creatorcontrib><creatorcontrib>Mohammadi-Torbati, Peyman</creatorcontrib><creatorcontrib>Kashi, Amir Hossein</creatorcontrib><creatorcontrib>Rezaee, Hanieh</creatorcontrib><creatorcontrib>Vaezjalali, Maryam</creatorcontrib><title>Polyomavirus Hominis 1(BK virus) Infection in Prostatic Tissues: Cancer versus Hyperplasia</title><title>Urology journal</title><addtitle>Urol J</addtitle><description>Polyomavirus hominis 1, better known as BK virus (BKV) infection might be a predisposing factor for prostate cancer (PCa). The aim of this study was to compare the frequency of BK virus infection in pathological specimens of patients with PCa compared to patients with benign prostatic hyperplasia.
From July 2011 to June 2012, paraffin-embedded tissue blocks of patients with PCa (60 specimens) and also with benign prostatic hyperplasia (60 specimens) were investigated. After DNA purification, existence of virus nucleic acid was assessed by polymerase chain reaction.
Viral DNA was identified in 9 patients (15%) with benign prostatic hyperplasia (BPH) and 17 patients (28%) with PCa (P = .076). In patients with PCa, viral DNA was observed more often in those with lower total Gleason scores (P = .045).
The frequency of BK virus infection in PCa patients was higher than BPH patients. BK virus was more often observed in patients with lower Gleason scores. Less detection of BK virus DNA in overt cancer may prove the activity of the virus which paves the way for tumorigenic transformation at early stages of PCa.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>BK Virus - genetics</subject><subject>DNA, Viral - analysis</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Incidence</subject><subject>Iran - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Polymerase Chain Reaction</subject><subject>Polyomavirus Infections - epidemiology</subject><subject>Polyomavirus Infections - virology</subject><subject>Prostate - pathology</subject><subject>Prostate - virology</subject><subject>Prostatic Hyperplasia - epidemiology</subject><subject>Prostatic Hyperplasia - pathology</subject><subject>Prostatic Hyperplasia - virology</subject><subject>Prostatic Neoplasms - epidemiology</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - virology</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Tumor Virus Infections - epidemiology</subject><subject>Tumor Virus Infections - virology</subject><issn>1735-1308</issn><issn>1735-546X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkEFLw0AQhYMotlb_gix4qYdANrPZZL1pUVss2EMF8RImuxvYkmTjblLov3fVepE5vDfDx-MxJ9GU5pDFGePvp0dPISkm0YX3uyTJwsLPo0nKgdGcZ9PoY2Obg21xb9zoydK2pjOe0PnDC_k53ZJVV2s5GNsR05GNs37AwUiyNd6P2t-RBXZSO7LXzn8nHHrt-ga9wcvorMbG66ujzqK3p8ftYhmvX59Xi_t13KcghlgIRTmA4hJYXauEpZXUqIFVRZUWqUKpGEdUwEHRvC7CYE0BNVY6TYSAWTT_ze2d_QyVhrI1XuqmwU7b0Zc0T0ROM8HzgN78Q3d2dF1oFyiasxSAs0BdH6mxarUqe2dadIfy72vwBTTCakM</recordid><startdate>20150904</startdate><enddate>20150904</enddate><creator>Taghavi, Afsoon</creator><creator>Mohammadi-Torbati, Peyman</creator><creator>Kashi, Amir Hossein</creator><creator>Rezaee, Hanieh</creator><creator>Vaezjalali, Maryam</creator><general>Urology and Nephrology Research Center</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20150904</creationdate><title>Polyomavirus Hominis 1(BK virus) Infection in Prostatic Tissues: Cancer versus Hyperplasia</title><author>Taghavi, Afsoon ; Mohammadi-Torbati, Peyman ; Kashi, Amir Hossein ; Rezaee, Hanieh ; Vaezjalali, Maryam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-99d1633d6c34ffd042bceae34b8b282dacd46aad363d17f8f8faf13aeabe20993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>BK Virus - genetics</topic><topic>DNA, Viral - analysis</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Incidence</topic><topic>Iran - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Polymerase Chain Reaction</topic><topic>Polyomavirus Infections - epidemiology</topic><topic>Polyomavirus Infections - virology</topic><topic>Prostate - pathology</topic><topic>Prostate - virology</topic><topic>Prostatic Hyperplasia - epidemiology</topic><topic>Prostatic Hyperplasia - pathology</topic><topic>Prostatic Hyperplasia - virology</topic><topic>Prostatic Neoplasms - epidemiology</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - virology</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Tumor Virus Infections - epidemiology</topic><topic>Tumor Virus Infections - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taghavi, Afsoon</creatorcontrib><creatorcontrib>Mohammadi-Torbati, Peyman</creatorcontrib><creatorcontrib>Kashi, Amir Hossein</creatorcontrib><creatorcontrib>Rezaee, Hanieh</creatorcontrib><creatorcontrib>Vaezjalali, Maryam</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Urology journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taghavi, Afsoon</au><au>Mohammadi-Torbati, Peyman</au><au>Kashi, Amir Hossein</au><au>Rezaee, Hanieh</au><au>Vaezjalali, Maryam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polyomavirus Hominis 1(BK virus) Infection in Prostatic Tissues: Cancer versus Hyperplasia</atitle><jtitle>Urology journal</jtitle><addtitle>Urol J</addtitle><date>2015-09-04</date><risdate>2015</risdate><volume>12</volume><issue>4</issue><spage>2240</spage><epage>2244</epage><pages>2240-2244</pages><issn>1735-1308</issn><eissn>1735-546X</eissn><abstract>Polyomavirus hominis 1, better known as BK virus (BKV) infection might be a predisposing factor for prostate cancer (PCa). The aim of this study was to compare the frequency of BK virus infection in pathological specimens of patients with PCa compared to patients with benign prostatic hyperplasia.
From July 2011 to June 2012, paraffin-embedded tissue blocks of patients with PCa (60 specimens) and also with benign prostatic hyperplasia (60 specimens) were investigated. After DNA purification, existence of virus nucleic acid was assessed by polymerase chain reaction.
Viral DNA was identified in 9 patients (15%) with benign prostatic hyperplasia (BPH) and 17 patients (28%) with PCa (P = .076). In patients with PCa, viral DNA was observed more often in those with lower total Gleason scores (P = .045).
The frequency of BK virus infection in PCa patients was higher than BPH patients. BK virus was more often observed in patients with lower Gleason scores. Less detection of BK virus DNA in overt cancer may prove the activity of the virus which paves the way for tumorigenic transformation at early stages of PCa.</abstract><cop>Iran</cop><pub>Urology and Nephrology Research Center</pub><pmid>26341765</pmid><tpages>5</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over BK Virus - genetics DNA, Viral - analysis Follow-Up Studies Humans Incidence Iran - epidemiology Male Middle Aged Neoplasm Grading Polymerase Chain Reaction Polyomavirus Infections - epidemiology Polyomavirus Infections - virology Prostate - pathology Prostate - virology Prostatic Hyperplasia - epidemiology Prostatic Hyperplasia - pathology Prostatic Hyperplasia - virology Prostatic Neoplasms - epidemiology Prostatic Neoplasms - pathology Prostatic Neoplasms - virology Retrospective Studies Risk Factors Tumor Virus Infections - epidemiology Tumor Virus Infections - virology |
| title | Polyomavirus Hominis 1(BK virus) Infection in Prostatic Tissues: Cancer versus Hyperplasia |
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