Disease evolution and outcomes in familial AML with germline CEBPA mutations

In-depth molecular investigation of familial leukemia has been limited by the rarity of recognized cases. This study examines the genetic events initiating leukemia and details the clinical progression of disease across multiple families harboring germ-line CEBPA mutations. Clinical data were collec...

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Veröffentlicht in:	Blood 2015-09, Vol.126 (10), p.1214-1223
Hauptverfasser:	Tawana, Kiran, Wang, Jun, Renneville, Aline, Bödör, Csaba, Hills, Robert, Loveday, Chey, Savic, Aleksandar, Van Delft, Frederik W., Treleaven, Jennifer, Georgiades, Panayiotis, Uglow, Elizabeth, Asou, Norio, Uike, Naokuni, Debeljak, Maruša, Jazbec, Janez, Ancliff, Philip, Gale, Rosemary, Thomas, Xavier, Mialou, Valerie, Döhner, Konstanze, Bullinger, Lars, Mueller, Beatrice, Pabst, Thomas, Stelljes, Matthias, Schlegelberger, Brigitte, Wozniak, Eva, Iqbal, Sameena, Okosun, Jessica, Araf, Shamzah, Frank, Anne-Katrine, Lauridsen, Felicia B., Porse, Bo, Nerlov, Claus, Owen, Carolyn, Dokal, Inderjeet, Gribben, John, Smith, Matthew, Preudhomme, Claude, Chelala, Claude, Cavenagh, Jamie, Fitzgibbon, Jude
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult CCAAT-Enhancer-Binding Proteins - genetics Child Child, Preschool Disease Progression Female Genetic Predisposition to Disease Germ-Line Mutation High-Throughput Nucleotide Sequencing Humans Infant Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - mortality Leukemia, Myeloid, Acute - pathology Male Middle Aged Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Pedigree Young Adult
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