Regulation of V2 receptor by vasopressin is different in Brattleboro rats compared with Wistar
This paper presents the new priority data on the effect of genetically determined deficiency of endogenous vasopressin on the functioning of V2 receptor in the plasma membrane of the principal cells of the collection ducts of Brattleboro rats. It was found that 2-day desmopressin administration resu...
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Veröffentlicht in: | Doklady. Biochemistry and biophysics 2015-07, Vol.463 (1), p.247-250 |
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creator | Katkova, L. E. Baturina, G. S. Solenov, E. I. Ivanova, L. N. |
description | This paper presents the new priority data on the effect of genetically determined deficiency of endogenous vasopressin on the functioning of V2 receptor in the plasma membrane of the principal cells of the collection ducts of Brattleboro rats. It was found that 2-day desmopressin administration results in the activation of V2 receptor gene expression in Brattleboro rat, whereas in Wistar rats the content of mRNA did not change. In addition, short-term exposure of the collection ducts of the kidneys to the hormone led to V2 receptor internalization from the plasma membrane in Wistar rats, but had no effect on the protein content in Brattleboro rats. |
doi_str_mv | 10.1134/S1607672915040158 |
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E. ; Baturina, G. S. ; Solenov, E. I. ; Ivanova, L. N.</creator><creatorcontrib>Katkova, L. E. ; Baturina, G. S. ; Solenov, E. I. ; Ivanova, L. N.</creatorcontrib><description>This paper presents the new priority data on the effect of genetically determined deficiency of endogenous vasopressin on the functioning of V2 receptor in the plasma membrane of the principal cells of the collection ducts of Brattleboro rats. It was found that 2-day desmopressin administration results in the activation of V2 receptor gene expression in Brattleboro rat, whereas in Wistar rats the content of mRNA did not change. In addition, short-term exposure of the collection ducts of the kidneys to the hormone led to V2 receptor internalization from the plasma membrane in Wistar rats, but had no effect on the protein content in Brattleboro rats.</description><identifier>ISSN: 1607-6729</identifier><identifier>EISSN: 1608-3091</identifier><identifier>DOI: 10.1134/S1607672915040158</identifier><identifier>PMID: 26335823</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Animals ; Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biophysics ; Biophysics and Molecular Biology ; Deamino Arginine Vasopressin - pharmacology ; Female ; Life Sciences ; Male ; Rats ; Rats, Brattleboro ; Rats, Wistar ; Receptors, Vasopressin - genetics ; Receptors, Vasopressin - metabolism ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Species Specificity</subject><ispartof>Doklady. 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E.</creatorcontrib><creatorcontrib>Baturina, G. S.</creatorcontrib><creatorcontrib>Solenov, E. I.</creatorcontrib><creatorcontrib>Ivanova, L. N.</creatorcontrib><title>Regulation of V2 receptor by vasopressin is different in Brattleboro rats compared with Wistar</title><title>Doklady. Biochemistry and biophysics</title><addtitle>Dokl Biochem Biophys</addtitle><addtitle>Dokl Biochem Biophys</addtitle><description>This paper presents the new priority data on the effect of genetically determined deficiency of endogenous vasopressin on the functioning of V2 receptor in the plasma membrane of the principal cells of the collection ducts of Brattleboro rats. It was found that 2-day desmopressin administration results in the activation of V2 receptor gene expression in Brattleboro rat, whereas in Wistar rats the content of mRNA did not change. In addition, short-term exposure of the collection ducts of the kidneys to the hormone led to V2 receptor internalization from the plasma membrane in Wistar rats, but had no effect on the protein content in Brattleboro rats.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomedical and Life Sciences</subject><subject>Biophysics</subject><subject>Biophysics and Molecular Biology</subject><subject>Deamino Arginine Vasopressin - pharmacology</subject><subject>Female</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Brattleboro</subject><subject>Rats, Wistar</subject><subject>Receptors, Vasopressin - genetics</subject><subject>Receptors, Vasopressin - metabolism</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Species Specificity</subject><issn>1607-6729</issn><issn>1608-3091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kEtLxDAUhYMoOj5-gBsJuHFTzaNp0qWKLxAEHXRnSdPbsUOnqUmq-O_NPBRRXOXmnu-emxyE9ik5ppSnJw80IzKTLKeCpIQKtYZGsaUSTnK6vqhlMte30Lb3U0IYYVxsoi2WcS4U4yP0fA-TodWhsR22NX5k2IGBPliHyw_8pr3tHXjfdLjxuGrqGhx0Acf7mdMhtFBaZ3EsPTZ21msHFX5vwgt-anzQbhdt1Lr1sLc6d9D48mJ8fp3c3l3dnJ_eJoZLFhIQRnGlSG0YUJaLOoWKZSkoznSlgUFZm7RMJQEKQktT8YxDxUUqSqPin3bQ0dK2d_Z1AB-KWeMNtK3uwA6-oJLkknJBZEQPf6FTO7guPm5BMUFUPqfokjLOeu-gLnrXzLT7KCgp5tkXf7KPMwcr56GcQfU98RV2BNgS8FHqJuB-rP7X9ROLMI35</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Katkova, L. 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subjects | Animals Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biophysics and Molecular Biology Deamino Arginine Vasopressin - pharmacology Female Life Sciences Male Rats Rats, Brattleboro Rats, Wistar Receptors, Vasopressin - genetics Receptors, Vasopressin - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Species Specificity |
title | Regulation of V2 receptor by vasopressin is different in Brattleboro rats compared with Wistar |
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