Regulation of V2 receptor by vasopressin is different in Brattleboro rats compared with Wistar

This paper presents the new priority data on the effect of genetically determined deficiency of endogenous vasopressin on the functioning of V2 receptor in the plasma membrane of the principal cells of the collection ducts of Brattleboro rats. It was found that 2-day desmopressin administration resu...

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Veröffentlicht in:Doklady. Biochemistry and biophysics 2015-07, Vol.463 (1), p.247-250
Hauptverfasser: Katkova, L. E., Baturina, G. S., Solenov, E. I., Ivanova, L. N.
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container_title Doklady. Biochemistry and biophysics
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creator Katkova, L. E.
Baturina, G. S.
Solenov, E. I.
Ivanova, L. N.
description This paper presents the new priority data on the effect of genetically determined deficiency of endogenous vasopressin on the functioning of V2 receptor in the plasma membrane of the principal cells of the collection ducts of Brattleboro rats. It was found that 2-day desmopressin administration results in the activation of V2 receptor gene expression in Brattleboro rat, whereas in Wistar rats the content of mRNA did not change. In addition, short-term exposure of the collection ducts of the kidneys to the hormone led to V2 receptor internalization from the plasma membrane in Wistar rats, but had no effect on the protein content in Brattleboro rats.
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subjects Animals
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biophysics and Molecular Biology
Deamino Arginine Vasopressin - pharmacology
Female
Life Sciences
Male
Rats
Rats, Brattleboro
Rats, Wistar
Receptors, Vasopressin - genetics
Receptors, Vasopressin - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
Species Specificity
title Regulation of V2 receptor by vasopressin is different in Brattleboro rats compared with Wistar
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