Lipid profile after long-term APAP in OSA patients
Purpose This study aimed to explore the impact of an 8-year therapy with autoadjusting positive airway pressure (APAP) on fasting lipid level in a sample of Portuguese moderate/severe obstructive sleep apnea (OSA) patients. Besides contributing to the comprehension of the complex relationship betwee...
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| Veröffentlicht in: | Sleep & breathing 2015-09, Vol.19 (3), p.931-937 |
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| creator | Rebelo, Sandra Drummond, Marta Marques, José Agostinho |
| description | Purpose
This study aimed to explore the impact of an 8-year therapy with autoadjusting positive airway pressure (APAP) on fasting lipid level in a sample of Portuguese moderate/severe obstructive sleep apnea (OSA) patients. Besides contributing to the comprehension of the complex relationship between dyslipidemia and OSA, it provided new data regarding the effectiveness of a long term APAP treatment.
Methods
Thirty-nine male patients with moderate to severe OSA were included in the study. APAP was prescribed to all patients. Fifteen patients were under lipid-lowering medication throughout the study, and another 15 patients never used lipid-lowering medication at any time during the study. Fasting morning venous blood samples were collected at three time points (baseline 6 months and 8 years) and lipids were estimated. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) 21.0 software.
Results
After 8 years of APAP treatment, patients presented a similar body mass index but a significantly less severe daytime sleepiness. Patients on lipid-lowering medication exhibited a higher reduction in total cholesterol than those naïf from that medication, but the reduction was not statistically significant after adjusting for medication and APAP adherence.
Conclusions
Long-term APAP treatment improves OSA but does not seem to contribute to changes in fasting lipids. |
| doi_str_mv | 10.1007/s11325-014-1095-5 |
| format | Article |
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This study aimed to explore the impact of an 8-year therapy with autoadjusting positive airway pressure (APAP) on fasting lipid level in a sample of Portuguese moderate/severe obstructive sleep apnea (OSA) patients. Besides contributing to the comprehension of the complex relationship between dyslipidemia and OSA, it provided new data regarding the effectiveness of a long term APAP treatment.
Methods
Thirty-nine male patients with moderate to severe OSA were included in the study. APAP was prescribed to all patients. Fifteen patients were under lipid-lowering medication throughout the study, and another 15 patients never used lipid-lowering medication at any time during the study. Fasting morning venous blood samples were collected at three time points (baseline 6 months and 8 years) and lipids were estimated. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) 21.0 software.
Results
After 8 years of APAP treatment, patients presented a similar body mass index but a significantly less severe daytime sleepiness. Patients on lipid-lowering medication exhibited a higher reduction in total cholesterol than those naïf from that medication, but the reduction was not statistically significant after adjusting for medication and APAP adherence.
Conclusions
Long-term APAP treatment improves OSA but does not seem to contribute to changes in fasting lipids.</description><identifier>ISSN: 1520-9512</identifier><identifier>EISSN: 1522-1709</identifier><identifier>DOI: 10.1007/s11325-014-1095-5</identifier><identifier>PMID: 25510508</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Airway management ; Combined Modality Therapy ; Continuous Positive Airway Pressure ; Dentistry ; Dyslipidemias - blood ; Dyslipidemias - therapy ; Humans ; Hypolipidemic Agents - therapeutic use ; Internal Medicine ; Lipids ; Lipids - blood ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate Analysis ; Neurology ; Original Article ; Otorhinolaryngology ; Pediatrics ; Pneumology/Respiratory System ; Polysomnography - drug effects ; Prospective Studies ; Sleep apnea ; Sleep Apnea, Obstructive - blood ; Sleep Apnea, Obstructive - therapy ; Statins</subject><ispartof>Sleep & breathing, 2015-09, Vol.19 (3), p.931-937</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-ed9717132de15ef0180081f8d93d7a107df7ce38f775130b25d08a6502e7b5cf3</citedby><cites>FETCH-LOGICAL-c405t-ed9717132de15ef0180081f8d93d7a107df7ce38f775130b25d08a6502e7b5cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11325-014-1095-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11325-014-1095-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25510508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rebelo, Sandra</creatorcontrib><creatorcontrib>Drummond, Marta</creatorcontrib><creatorcontrib>Marques, José Agostinho</creatorcontrib><title>Lipid profile after long-term APAP in OSA patients</title><title>Sleep & breathing</title><addtitle>Sleep Breath</addtitle><addtitle>Sleep Breath</addtitle><description>Purpose
This study aimed to explore the impact of an 8-year therapy with autoadjusting positive airway pressure (APAP) on fasting lipid level in a sample of Portuguese moderate/severe obstructive sleep apnea (OSA) patients. Besides contributing to the comprehension of the complex relationship between dyslipidemia and OSA, it provided new data regarding the effectiveness of a long term APAP treatment.
Methods
Thirty-nine male patients with moderate to severe OSA were included in the study. APAP was prescribed to all patients. Fifteen patients were under lipid-lowering medication throughout the study, and another 15 patients never used lipid-lowering medication at any time during the study. Fasting morning venous blood samples were collected at three time points (baseline 6 months and 8 years) and lipids were estimated. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) 21.0 software.
Results
After 8 years of APAP treatment, patients presented a similar body mass index but a significantly less severe daytime sleepiness. Patients on lipid-lowering medication exhibited a higher reduction in total cholesterol than those naïf from that medication, but the reduction was not statistically significant after adjusting for medication and APAP adherence.
Conclusions
Long-term APAP treatment improves OSA but does not seem to contribute to changes in fasting lipids.</description><subject>Adult</subject><subject>Aged</subject><subject>Airway management</subject><subject>Combined Modality Therapy</subject><subject>Continuous Positive Airway Pressure</subject><subject>Dentistry</subject><subject>Dyslipidemias - blood</subject><subject>Dyslipidemias - therapy</subject><subject>Humans</subject><subject>Hypolipidemic Agents - therapeutic use</subject><subject>Internal Medicine</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neurology</subject><subject>Original Article</subject><subject>Otorhinolaryngology</subject><subject>Pediatrics</subject><subject>Pneumology/Respiratory System</subject><subject>Polysomnography - drug effects</subject><subject>Prospective Studies</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - blood</subject><subject>Sleep Apnea, Obstructive - therapy</subject><subject>Statins</subject><issn>1520-9512</issn><issn>1522-1709</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kE1LAzEQhoMoVqs_wIssePESncl2mt3jUvyCQgvqOWw3SdmyXybbg__etFtFBE8ZyDNv3jyMXSHcIYC894ixIA444QgpcTpiZ0hCcJSQHu9n4CmhGLFz7zcQwCTFUzYSRAgEyRkT87IrddS51paViXLbGxdVbbPmYaijbJkto7KJFq9Z1OV9aZreX7ATm1feXB7OMXt_fHibPfP54ullls15MQHqudGpRBkKaoNkLGACkKBNdBprmSNIbWVh4sRKSRjDSpCGJJ8SCCNXVNh4zG6H3FDuY2t8r-rSF6aq8sa0W692n5QhZwoBvfmDbtqta0K7PSVIpIkMFA5U4VrvnbGqc2Wdu0-FoHZC1SBUBU9qJ1RR2Lk-JG9XtdE_G98GAyAGwIerZm3cr6f_Tf0CyEh8ng</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Rebelo, Sandra</creator><creator>Drummond, Marta</creator><creator>Marques, José Agostinho</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2R</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150901</creationdate><title>Lipid profile after long-term APAP in OSA patients</title><author>Rebelo, Sandra ; Drummond, Marta ; Marques, José Agostinho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-ed9717132de15ef0180081f8d93d7a107df7ce38f775130b25d08a6502e7b5cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Airway management</topic><topic>Combined Modality Therapy</topic><topic>Continuous Positive Airway Pressure</topic><topic>Dentistry</topic><topic>Dyslipidemias - blood</topic><topic>Dyslipidemias - therapy</topic><topic>Humans</topic><topic>Hypolipidemic Agents - therapeutic use</topic><topic>Internal Medicine</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neurology</topic><topic>Original Article</topic><topic>Otorhinolaryngology</topic><topic>Pediatrics</topic><topic>Pneumology/Respiratory System</topic><topic>Polysomnography - drug effects</topic><topic>Prospective Studies</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - blood</topic><topic>Sleep Apnea, Obstructive - therapy</topic><topic>Statins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rebelo, Sandra</creatorcontrib><creatorcontrib>Drummond, Marta</creatorcontrib><creatorcontrib>Marques, José Agostinho</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Social Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Sleep & breathing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rebelo, Sandra</au><au>Drummond, Marta</au><au>Marques, José Agostinho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipid profile after long-term APAP in OSA patients</atitle><jtitle>Sleep & breathing</jtitle><stitle>Sleep Breath</stitle><addtitle>Sleep Breath</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>19</volume><issue>3</issue><spage>931</spage><epage>937</epage><pages>931-937</pages><issn>1520-9512</issn><eissn>1522-1709</eissn><abstract>Purpose
This study aimed to explore the impact of an 8-year therapy with autoadjusting positive airway pressure (APAP) on fasting lipid level in a sample of Portuguese moderate/severe obstructive sleep apnea (OSA) patients. Besides contributing to the comprehension of the complex relationship between dyslipidemia and OSA, it provided new data regarding the effectiveness of a long term APAP treatment.
Methods
Thirty-nine male patients with moderate to severe OSA were included in the study. APAP was prescribed to all patients. Fifteen patients were under lipid-lowering medication throughout the study, and another 15 patients never used lipid-lowering medication at any time during the study. Fasting morning venous blood samples were collected at three time points (baseline 6 months and 8 years) and lipids were estimated. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) 21.0 software.
Results
After 8 years of APAP treatment, patients presented a similar body mass index but a significantly less severe daytime sleepiness. Patients on lipid-lowering medication exhibited a higher reduction in total cholesterol than those naïf from that medication, but the reduction was not statistically significant after adjusting for medication and APAP adherence.
Conclusions
Long-term APAP treatment improves OSA but does not seem to contribute to changes in fasting lipids.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25510508</pmid><doi>10.1007/s11325-014-1095-5</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 1520-9512 |
| ispartof | Sleep & breathing, 2015-09, Vol.19 (3), p.931-937 |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Aged Airway management Combined Modality Therapy Continuous Positive Airway Pressure Dentistry Dyslipidemias - blood Dyslipidemias - therapy Humans Hypolipidemic Agents - therapeutic use Internal Medicine Lipids Lipids - blood Male Medicine Medicine & Public Health Middle Aged Multivariate Analysis Neurology Original Article Otorhinolaryngology Pediatrics Pneumology/Respiratory System Polysomnography - drug effects Prospective Studies Sleep apnea Sleep Apnea, Obstructive - blood Sleep Apnea, Obstructive - therapy Statins |
| title | Lipid profile after long-term APAP in OSA patients |
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