Hepatitis B vaccine alone or with hepatitis B immunoglobulin in neonates of HBsAg+/HBeAg- mothers: a systematic review and meta-analysis
The cost-effectiveness of augmenting immunization against hepatitis B infection with hepatitis B immunoglobulin (HBIG) remains controversial, particularly for the subpopulation of babies of HBsAg+/HBeAg- mothers that are considered as low-infective. We aimed to evaluate the effectiveness of vaccine...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 2015-02, Vol.70 (2), p.396-404 |
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| container_title | Journal of antimicrobial chemotherapy |
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| creator | Machaira, Maria Papaevangelou, Vassiliki Vouloumanou, Evridiki K Tansarli, Giannoula S Falagas, Matthew E |
| description | The cost-effectiveness of augmenting immunization against hepatitis B infection with hepatitis B immunoglobulin (HBIG) remains controversial, particularly for the subpopulation of babies of HBsAg+/HBeAg- mothers that are considered as low-infective. We aimed to evaluate the effectiveness of vaccine alone compared with vaccine plus HBIG for the immunization of babies of HBsAg+/HBeAg- mothers.
We searched PubMed, Scopus and Cochrane Central Register of Controlled Trials databases to identify studies comparing the effectiveness of combined immunization (vaccine plus HBIG) with vaccine alone in neonates of HBsAg+/HBeAg- mothers. A systematic review and meta-analysis of eligible studies was performed.
A total of nine eligible studies were identified (four randomized controlled trials). No difference was found regarding the primary outcome of our meta-analysis, namely occurrence of hepatitis B infection, between neonates who received vaccine only, compared with those who received both vaccine and HBIG (four studies, 3426 patients, OR=0.82, 95% CI=0.41-1.64). This finding was consistent with regards to seroprotection rate (four studies, 1323 patients, OR=1.24, 95% CI=0.97-1.58). Safety data were not reported in the included studies.
The available limited published evidence suggests that vaccine alone seems to be equally effective to the combination of HBIG and hepatitis B vaccine for neonates of HBsAg+/HBeAg- mothers in preventing infection. Further studies are needed in order to clarify the potential benefit of combined immunization to this specific subgroup of patients. |
| doi_str_mv | 10.1093/jac/dku404 |
| format | Article |
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We searched PubMed, Scopus and Cochrane Central Register of Controlled Trials databases to identify studies comparing the effectiveness of combined immunization (vaccine plus HBIG) with vaccine alone in neonates of HBsAg+/HBeAg- mothers. A systematic review and meta-analysis of eligible studies was performed.
A total of nine eligible studies were identified (four randomized controlled trials). No difference was found regarding the primary outcome of our meta-analysis, namely occurrence of hepatitis B infection, between neonates who received vaccine only, compared with those who received both vaccine and HBIG (four studies, 3426 patients, OR=0.82, 95% CI=0.41-1.64). This finding was consistent with regards to seroprotection rate (four studies, 1323 patients, OR=1.24, 95% CI=0.97-1.58). Safety data were not reported in the included studies.
The available limited published evidence suggests that vaccine alone seems to be equally effective to the combination of HBIG and hepatitis B vaccine for neonates of HBsAg+/HBeAg- mothers in preventing infection. Further studies are needed in order to clarify the potential benefit of combined immunization to this specific subgroup of patients.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/dku404</identifier><identifier>PMID: 25362571</identifier><language>eng</language><publisher>England: Oxford Publishing Limited (England)</publisher><subject>Hepatitis ; Hepatitis B ; Hepatitis B - epidemiology ; Hepatitis B - prevention & control ; Hepatitis B - transmission ; Hepatitis B Surface Antigens - blood ; Hepatitis B Vaccines - immunology ; Humans ; Immunoglobulins - blood ; Infant ; Infant, Newborn ; Infectious Disease Transmission, Vertical - prevention & control ; Infectious Disease Transmission, Vertical - statistics & numerical data ; Meta-analysis ; Mothers ; Newborn babies ; Odds Ratio ; Patient Outcome Assessment ; Systematic review ; Vaccines</subject><ispartof>Journal of antimicrobial chemotherapy, 2015-02, Vol.70 (2), p.396-404</ispartof><rights>The Author 2014. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.</rights><rights>Copyright Oxford Publishing Limited(England) Feb 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2664-d8d0a1a73534e1ff3861374498fea6c2a2039f271fee61a39af5b681cc45745e3</citedby><cites>FETCH-LOGICAL-c2664-d8d0a1a73534e1ff3861374498fea6c2a2039f271fee61a39af5b681cc45745e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25362571$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Machaira, Maria</creatorcontrib><creatorcontrib>Papaevangelou, Vassiliki</creatorcontrib><creatorcontrib>Vouloumanou, Evridiki K</creatorcontrib><creatorcontrib>Tansarli, Giannoula S</creatorcontrib><creatorcontrib>Falagas, Matthew E</creatorcontrib><title>Hepatitis B vaccine alone or with hepatitis B immunoglobulin in neonates of HBsAg+/HBeAg- mothers: a systematic review and meta-analysis</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>The cost-effectiveness of augmenting immunization against hepatitis B infection with hepatitis B immunoglobulin (HBIG) remains controversial, particularly for the subpopulation of babies of HBsAg+/HBeAg- mothers that are considered as low-infective. We aimed to evaluate the effectiveness of vaccine alone compared with vaccine plus HBIG for the immunization of babies of HBsAg+/HBeAg- mothers.
We searched PubMed, Scopus and Cochrane Central Register of Controlled Trials databases to identify studies comparing the effectiveness of combined immunization (vaccine plus HBIG) with vaccine alone in neonates of HBsAg+/HBeAg- mothers. A systematic review and meta-analysis of eligible studies was performed.
A total of nine eligible studies were identified (four randomized controlled trials). No difference was found regarding the primary outcome of our meta-analysis, namely occurrence of hepatitis B infection, between neonates who received vaccine only, compared with those who received both vaccine and HBIG (four studies, 3426 patients, OR=0.82, 95% CI=0.41-1.64). This finding was consistent with regards to seroprotection rate (four studies, 1323 patients, OR=1.24, 95% CI=0.97-1.58). Safety data were not reported in the included studies.
The available limited published evidence suggests that vaccine alone seems to be equally effective to the combination of HBIG and hepatitis B vaccine for neonates of HBsAg+/HBeAg- mothers in preventing infection. Further studies are needed in order to clarify the potential benefit of combined immunization to this specific subgroup of patients.</description><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B - epidemiology</subject><subject>Hepatitis B - prevention & control</subject><subject>Hepatitis B - transmission</subject><subject>Hepatitis B Surface Antigens - blood</subject><subject>Hepatitis B Vaccines - immunology</subject><subject>Humans</subject><subject>Immunoglobulins - blood</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infectious Disease Transmission, Vertical - prevention & control</subject><subject>Infectious Disease Transmission, Vertical - statistics & numerical data</subject><subject>Meta-analysis</subject><subject>Mothers</subject><subject>Newborn babies</subject><subject>Odds Ratio</subject><subject>Patient Outcome Assessment</subject><subject>Systematic review</subject><subject>Vaccines</subject><issn>0305-7453</issn><issn>1460-2091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkcGO0zAQhi0EYsvChQdAlrggUKjHdpxkb-1qlyKtxAXO0dQZty5JXOxkV30DHhujLgghjWYun37NzMfYaxAfQTRqeUC77L7PWugnbAHaiEKKBp6yhVCiLCpdqgv2IqWDEMKUpn7OLmSpjCwrWLCfGzri5Cef-Jrfo7V-JI59yD1E_uCnPd__Q_hhmMew68N27v3Ic40URpwo8eD4Zp1Wuw_LzZpWu4IPYdpTTFcceTqliYacYnmke08PHMeODzRhgSP2p-TTS_bMYZ_o1eO8ZN9ub75eb4q7L58-X6_uCiuN0UVXdwIBK1UqTeCcqg2oSuumdoTGSpRCNU5W4IgMoGrQlVtTg7W6zJ8gdcnenXOPMfyYKU3t4JOlvsd8yZxaqERTgTAAGX37H3oIc8z7ZsroqpZSgczU-zNlY0gpkmuP0Q8YTy2I9refNvtpz34y_OYxct4O1P1F_whRvwAA6ovV</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Machaira, Maria</creator><creator>Papaevangelou, Vassiliki</creator><creator>Vouloumanou, Evridiki K</creator><creator>Tansarli, Giannoula S</creator><creator>Falagas, Matthew E</creator><general>Oxford Publishing Limited (England)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201502</creationdate><title>Hepatitis B vaccine alone or with hepatitis B immunoglobulin in neonates of HBsAg+/HBeAg- mothers: a systematic review and meta-analysis</title><author>Machaira, Maria ; Papaevangelou, Vassiliki ; Vouloumanou, Evridiki K ; Tansarli, Giannoula S ; Falagas, Matthew E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2664-d8d0a1a73534e1ff3861374498fea6c2a2039f271fee61a39af5b681cc45745e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatitis B - epidemiology</topic><topic>Hepatitis B - prevention & control</topic><topic>Hepatitis B - transmission</topic><topic>Hepatitis B Surface Antigens - blood</topic><topic>Hepatitis B Vaccines - immunology</topic><topic>Humans</topic><topic>Immunoglobulins - blood</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infectious Disease Transmission, Vertical - prevention & control</topic><topic>Infectious Disease Transmission, Vertical - statistics & numerical data</topic><topic>Meta-analysis</topic><topic>Mothers</topic><topic>Newborn babies</topic><topic>Odds Ratio</topic><topic>Patient Outcome Assessment</topic><topic>Systematic review</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Machaira, Maria</creatorcontrib><creatorcontrib>Papaevangelou, Vassiliki</creatorcontrib><creatorcontrib>Vouloumanou, Evridiki K</creatorcontrib><creatorcontrib>Tansarli, Giannoula S</creatorcontrib><creatorcontrib>Falagas, Matthew E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antimicrobial chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Machaira, Maria</au><au>Papaevangelou, Vassiliki</au><au>Vouloumanou, Evridiki K</au><au>Tansarli, Giannoula S</au><au>Falagas, Matthew E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis B vaccine alone or with hepatitis B immunoglobulin in neonates of HBsAg+/HBeAg- mothers: a systematic review and meta-analysis</atitle><jtitle>Journal of antimicrobial chemotherapy</jtitle><addtitle>J Antimicrob Chemother</addtitle><date>2015-02</date><risdate>2015</risdate><volume>70</volume><issue>2</issue><spage>396</spage><epage>404</epage><pages>396-404</pages><issn>0305-7453</issn><eissn>1460-2091</eissn><abstract>The cost-effectiveness of augmenting immunization against hepatitis B infection with hepatitis B immunoglobulin (HBIG) remains controversial, particularly for the subpopulation of babies of HBsAg+/HBeAg- mothers that are considered as low-infective. We aimed to evaluate the effectiveness of vaccine alone compared with vaccine plus HBIG for the immunization of babies of HBsAg+/HBeAg- mothers.
We searched PubMed, Scopus and Cochrane Central Register of Controlled Trials databases to identify studies comparing the effectiveness of combined immunization (vaccine plus HBIG) with vaccine alone in neonates of HBsAg+/HBeAg- mothers. A systematic review and meta-analysis of eligible studies was performed.
A total of nine eligible studies were identified (four randomized controlled trials). No difference was found regarding the primary outcome of our meta-analysis, namely occurrence of hepatitis B infection, between neonates who received vaccine only, compared with those who received both vaccine and HBIG (four studies, 3426 patients, OR=0.82, 95% CI=0.41-1.64). This finding was consistent with regards to seroprotection rate (four studies, 1323 patients, OR=1.24, 95% CI=0.97-1.58). Safety data were not reported in the included studies.
The available limited published evidence suggests that vaccine alone seems to be equally effective to the combination of HBIG and hepatitis B vaccine for neonates of HBsAg+/HBeAg- mothers in preventing infection. Further studies are needed in order to clarify the potential benefit of combined immunization to this specific subgroup of patients.</abstract><cop>England</cop><pub>Oxford Publishing Limited (England)</pub><pmid>25362571</pmid><doi>10.1093/jac/dku404</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Hepatitis Hepatitis B Hepatitis B - epidemiology Hepatitis B - prevention & control Hepatitis B - transmission Hepatitis B Surface Antigens - blood Hepatitis B Vaccines - immunology Humans Immunoglobulins - blood Infant Infant, Newborn Infectious Disease Transmission, Vertical - prevention & control Infectious Disease Transmission, Vertical - statistics & numerical data Meta-analysis Mothers Newborn babies Odds Ratio Patient Outcome Assessment Systematic review Vaccines |
| title | Hepatitis B vaccine alone or with hepatitis B immunoglobulin in neonates of HBsAg+/HBeAg- mothers: a systematic review and meta-analysis |
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