Pharmacokinetic/pharmacodynamic assessments of 10 mg/kg tramadol intramuscular injection in yellow-bellied slider turtles (Trachemys scripta scripta)

In reptiles, administration of opioid drugs has yielded unexpected results with respect to analgesia. The aims of this study were to assess the pharmacokinetic/pharmacodynamic (PK/PD) properties of tramadol and its active metabolite M1 and to evaluate the effect of the renal portal system on the PK/...

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Veröffentlicht in:	Journal of veterinary pharmacology and therapeutics 2015-10, Vol.38 (5), p.488-496
Hauptverfasser:	Giorgi, M., Salvadori, M., De Vito, V., Owen, H., Demontis, M. P., Varoni, M. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Opioid - administration & dosage Analgesics, Opioid - blood Analgesics, Opioid - pharmacokinetics Animals Female Forelimb Hindlimb Injections, Intramuscular - veterinary Male Tramadol - administration & dosage Tramadol - blood Tramadol - pharmacokinetics Turtles - blood Turtles - metabolism
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