Association of Mitral Annular Calcification with Left Ventricular Mechanics: A Speckle Tracking Study
Background Mitral annular calcification (MAC) is a common echocardiographic finding in clinical practice and is associated with cardiovascular risk factors and atherosclerosis. However, data regarding left ventricular (LV) functions are lacking. We aimed to evaluate the relationship between MAC and...
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| Veröffentlicht in: | Echocardiography (Mount Kisco, N.Y.) N.Y.), 2015-09, Vol.32 (9), p.1374-1383 |
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| creator | Gökdeniz, Tayyar Boyaci, Faruk Hatem, Engin Bektaş, Hüseyin Kalaycıoğlu, Ezgi Gürsoy, Mustafa Ozan Aykan, Ahmet Çağrı Yıldız, Banu Şahin Altıntaş, Bernas |
| description | Background
Mitral annular calcification (MAC) is a common echocardiographic finding in clinical practice and is associated with cardiovascular risk factors and atherosclerosis. However, data regarding left ventricular (LV) functions are lacking. We aimed to evaluate the relationship between MAC and LV mechanical functions with the utility of two‐dimensional speckle tracking echocardiography (2DSTE).
Methods
The study involved 91 patients with MAC and 48 control subjects. Mitral annular thickness of 1–2 mm was reported as mild, 2–5 mm as moderate, and >5 mm as severe MAC. All patients underwent 2D echocardiography.
Results
MAC was observed in 91 (65.5%) patients. Of LV diastolic parameters, E/Em ratio, LAVI, LV mass index, and t‐LV UR were increased. Of LV systolic parameters, GLS and Sm were decreased, whereas Ar, Ar‐rate systole, peak LV twist, peak LV twist rate, LV‐tor, and MPI were increased, which were all correlated with presence and severity of MAC. Multivariate linear regression analysis showed that LV mass index (β = 0.225, P = 0.012), t‐LV UR (β = 0.370, P |
| doi_str_mv | 10.1111/echo.12861 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1709706035</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1709706035</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4371-1aa38c7050a401e53c871e90cb29fbdf94c818188bc50635d654c5d4ab3188a83</originalsourceid><addsrcrecordid>eNp9kEFP3DAQhS1EVba0F34A8hEhhXpiO3a4rVYLVFoKCAoSF8uZOGA2myx2Irr_voEAx84cRpr53hvpEbIH7AiG-unwsT2CVGewRSYgBUs0KLlNJkyJNEl1mu6QbzE-McYUgPhKdlIpFGQ5nxA3jbFFbzvfNrSt6Lnvgq3ptGn62gY6szX6yuN4f_HdI124qqO3rumCxzfmfPhvG4_xmE7p9drhsnb0Jlhc-uaBXnd9uflOvlS2ju7H-9wlf07mN7OzZHFx-ms2XSQouIIErOUaFZPMCgZOctQKXM6wSPOqKKtcoIahdYGSZVyWmRQoS2ELPiyt5rvkYPRdh_a5d7EzKx_R1bVtXNtHA4rlimWMywE9HFEMbYzBVWYd_MqGjQFmXmM1r7Gat1gHeP_dty9WrvxEP3IcABiBF1-7zX-szHx2dvFhmowaHzv391Njw9Jkiitp7n6fmksG-v7q9sRI_g-NdZEW</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1709706035</pqid></control><display><type>article</type><title>Association of Mitral Annular Calcification with Left Ventricular Mechanics: A Speckle Tracking Study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Gökdeniz, Tayyar ; Boyaci, Faruk ; Hatem, Engin ; Bektaş, Hüseyin ; Kalaycıoğlu, Ezgi ; Gürsoy, Mustafa Ozan ; Aykan, Ahmet Çağrı ; Yıldız, Banu Şahin ; Altıntaş, Bernas</creator><creatorcontrib>Gökdeniz, Tayyar ; Boyaci, Faruk ; Hatem, Engin ; Bektaş, Hüseyin ; Kalaycıoğlu, Ezgi ; Gürsoy, Mustafa Ozan ; Aykan, Ahmet Çağrı ; Yıldız, Banu Şahin ; Altıntaş, Bernas</creatorcontrib><description>Background
Mitral annular calcification (MAC) is a common echocardiographic finding in clinical practice and is associated with cardiovascular risk factors and atherosclerosis. However, data regarding left ventricular (LV) functions are lacking. We aimed to evaluate the relationship between MAC and LV mechanical functions with the utility of two‐dimensional speckle tracking echocardiography (2DSTE).
Methods
The study involved 91 patients with MAC and 48 control subjects. Mitral annular thickness of 1–2 mm was reported as mild, 2–5 mm as moderate, and >5 mm as severe MAC. All patients underwent 2D echocardiography.
Results
MAC was observed in 91 (65.5%) patients. Of LV diastolic parameters, E/Em ratio, LAVI, LV mass index, and t‐LV UR were increased. Of LV systolic parameters, GLS and Sm were decreased, whereas Ar, Ar‐rate systole, peak LV twist, peak LV twist rate, LV‐tor, and MPI were increased, which were all correlated with presence and severity of MAC. Multivariate linear regression analysis showed that LV mass index (β = 0.225, P = 0.012), t‐LV UR (β = 0.370, P < 0.001), LV mass index (β = 0.183, P = 0.025), MPI (β = 0.288, P < 0.001), and GLS (β = −0.385, P < 0.001) were significantly associated with MAC severity.
Conclusion
The presence and severity of MAC is associated with impaired LV systolic and diastolic functions. Therefore, preventive strategies might be taken in patients with MAC to avoid LV systolic and diastolic dysfunction.</description><identifier>ISSN: 0742-2822</identifier><identifier>EISSN: 1540-8175</identifier><identifier>DOI: 10.1111/echo.12861</identifier><identifier>PMID: 25471693</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Aged ; Calcinosis - complications ; Calcinosis - diagnostic imaging ; Cross-Sectional Studies ; Female ; Humans ; left ventricular mechanical functions ; Male ; mitral annular calcification ; Mitral Valve - diagnostic imaging ; Prospective Studies ; Risk Factors ; subclinical left ventricle systolic dysfunction ; Treatment Outcome ; two-dimensional speckle tracking echocardiography ; Ultrasonography ; Ventricular Dysfunction, Left - complications ; Ventricular Dysfunction, Left - diagnostic imaging</subject><ispartof>Echocardiography (Mount Kisco, N.Y.), 2015-09, Vol.32 (9), p.1374-1383</ispartof><rights>2014, Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4371-1aa38c7050a401e53c871e90cb29fbdf94c818188bc50635d654c5d4ab3188a83</citedby><cites>FETCH-LOGICAL-c4371-1aa38c7050a401e53c871e90cb29fbdf94c818188bc50635d654c5d4ab3188a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fecho.12861$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fecho.12861$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25471693$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gökdeniz, Tayyar</creatorcontrib><creatorcontrib>Boyaci, Faruk</creatorcontrib><creatorcontrib>Hatem, Engin</creatorcontrib><creatorcontrib>Bektaş, Hüseyin</creatorcontrib><creatorcontrib>Kalaycıoğlu, Ezgi</creatorcontrib><creatorcontrib>Gürsoy, Mustafa Ozan</creatorcontrib><creatorcontrib>Aykan, Ahmet Çağrı</creatorcontrib><creatorcontrib>Yıldız, Banu Şahin</creatorcontrib><creatorcontrib>Altıntaş, Bernas</creatorcontrib><title>Association of Mitral Annular Calcification with Left Ventricular Mechanics: A Speckle Tracking Study</title><title>Echocardiography (Mount Kisco, N.Y.)</title><addtitle>Echocardiography</addtitle><description>Background
Mitral annular calcification (MAC) is a common echocardiographic finding in clinical practice and is associated with cardiovascular risk factors and atherosclerosis. However, data regarding left ventricular (LV) functions are lacking. We aimed to evaluate the relationship between MAC and LV mechanical functions with the utility of two‐dimensional speckle tracking echocardiography (2DSTE).
Methods
The study involved 91 patients with MAC and 48 control subjects. Mitral annular thickness of 1–2 mm was reported as mild, 2–5 mm as moderate, and >5 mm as severe MAC. All patients underwent 2D echocardiography.
Results
MAC was observed in 91 (65.5%) patients. Of LV diastolic parameters, E/Em ratio, LAVI, LV mass index, and t‐LV UR were increased. Of LV systolic parameters, GLS and Sm were decreased, whereas Ar, Ar‐rate systole, peak LV twist, peak LV twist rate, LV‐tor, and MPI were increased, which were all correlated with presence and severity of MAC. Multivariate linear regression analysis showed that LV mass index (β = 0.225, P = 0.012), t‐LV UR (β = 0.370, P < 0.001), LV mass index (β = 0.183, P = 0.025), MPI (β = 0.288, P < 0.001), and GLS (β = −0.385, P < 0.001) were significantly associated with MAC severity.
Conclusion
The presence and severity of MAC is associated with impaired LV systolic and diastolic functions. Therefore, preventive strategies might be taken in patients with MAC to avoid LV systolic and diastolic dysfunction.</description><subject>Aged</subject><subject>Calcinosis - complications</subject><subject>Calcinosis - diagnostic imaging</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>left ventricular mechanical functions</subject><subject>Male</subject><subject>mitral annular calcification</subject><subject>Mitral Valve - diagnostic imaging</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>subclinical left ventricle systolic dysfunction</subject><subject>Treatment Outcome</subject><subject>two-dimensional speckle tracking echocardiography</subject><subject>Ultrasonography</subject><subject>Ventricular Dysfunction, Left - complications</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><issn>0742-2822</issn><issn>1540-8175</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFP3DAQhS1EVba0F34A8hEhhXpiO3a4rVYLVFoKCAoSF8uZOGA2myx2Irr_voEAx84cRpr53hvpEbIH7AiG-unwsT2CVGewRSYgBUs0KLlNJkyJNEl1mu6QbzE-McYUgPhKdlIpFGQ5nxA3jbFFbzvfNrSt6Lnvgq3ptGn62gY6szX6yuN4f_HdI124qqO3rumCxzfmfPhvG4_xmE7p9drhsnb0Jlhc-uaBXnd9uflOvlS2ju7H-9wlf07mN7OzZHFx-ms2XSQouIIErOUaFZPMCgZOctQKXM6wSPOqKKtcoIahdYGSZVyWmRQoS2ELPiyt5rvkYPRdh_a5d7EzKx_R1bVtXNtHA4rlimWMywE9HFEMbYzBVWYd_MqGjQFmXmM1r7Gat1gHeP_dty9WrvxEP3IcABiBF1-7zX-szHx2dvFhmowaHzv391Njw9Jkiitp7n6fmksG-v7q9sRI_g-NdZEW</recordid><startdate>201509</startdate><enddate>201509</enddate><creator>Gökdeniz, Tayyar</creator><creator>Boyaci, Faruk</creator><creator>Hatem, Engin</creator><creator>Bektaş, Hüseyin</creator><creator>Kalaycıoğlu, Ezgi</creator><creator>Gürsoy, Mustafa Ozan</creator><creator>Aykan, Ahmet Çağrı</creator><creator>Yıldız, Banu Şahin</creator><creator>Altıntaş, Bernas</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201509</creationdate><title>Association of Mitral Annular Calcification with Left Ventricular Mechanics: A Speckle Tracking Study</title><author>Gökdeniz, Tayyar ; Boyaci, Faruk ; Hatem, Engin ; Bektaş, Hüseyin ; Kalaycıoğlu, Ezgi ; Gürsoy, Mustafa Ozan ; Aykan, Ahmet Çağrı ; Yıldız, Banu Şahin ; Altıntaş, Bernas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4371-1aa38c7050a401e53c871e90cb29fbdf94c818188bc50635d654c5d4ab3188a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Calcinosis - complications</topic><topic>Calcinosis - diagnostic imaging</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>left ventricular mechanical functions</topic><topic>Male</topic><topic>mitral annular calcification</topic><topic>Mitral Valve - diagnostic imaging</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>subclinical left ventricle systolic dysfunction</topic><topic>Treatment Outcome</topic><topic>two-dimensional speckle tracking echocardiography</topic><topic>Ultrasonography</topic><topic>Ventricular Dysfunction, Left - complications</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gökdeniz, Tayyar</creatorcontrib><creatorcontrib>Boyaci, Faruk</creatorcontrib><creatorcontrib>Hatem, Engin</creatorcontrib><creatorcontrib>Bektaş, Hüseyin</creatorcontrib><creatorcontrib>Kalaycıoğlu, Ezgi</creatorcontrib><creatorcontrib>Gürsoy, Mustafa Ozan</creatorcontrib><creatorcontrib>Aykan, Ahmet Çağrı</creatorcontrib><creatorcontrib>Yıldız, Banu Şahin</creatorcontrib><creatorcontrib>Altıntaş, Bernas</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Echocardiography (Mount Kisco, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gökdeniz, Tayyar</au><au>Boyaci, Faruk</au><au>Hatem, Engin</au><au>Bektaş, Hüseyin</au><au>Kalaycıoğlu, Ezgi</au><au>Gürsoy, Mustafa Ozan</au><au>Aykan, Ahmet Çağrı</au><au>Yıldız, Banu Şahin</au><au>Altıntaş, Bernas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Mitral Annular Calcification with Left Ventricular Mechanics: A Speckle Tracking Study</atitle><jtitle>Echocardiography (Mount Kisco, N.Y.)</jtitle><addtitle>Echocardiography</addtitle><date>2015-09</date><risdate>2015</risdate><volume>32</volume><issue>9</issue><spage>1374</spage><epage>1383</epage><pages>1374-1383</pages><issn>0742-2822</issn><eissn>1540-8175</eissn><abstract>Background
Mitral annular calcification (MAC) is a common echocardiographic finding in clinical practice and is associated with cardiovascular risk factors and atherosclerosis. However, data regarding left ventricular (LV) functions are lacking. We aimed to evaluate the relationship between MAC and LV mechanical functions with the utility of two‐dimensional speckle tracking echocardiography (2DSTE).
Methods
The study involved 91 patients with MAC and 48 control subjects. Mitral annular thickness of 1–2 mm was reported as mild, 2–5 mm as moderate, and >5 mm as severe MAC. All patients underwent 2D echocardiography.
Results
MAC was observed in 91 (65.5%) patients. Of LV diastolic parameters, E/Em ratio, LAVI, LV mass index, and t‐LV UR were increased. Of LV systolic parameters, GLS and Sm were decreased, whereas Ar, Ar‐rate systole, peak LV twist, peak LV twist rate, LV‐tor, and MPI were increased, which were all correlated with presence and severity of MAC. Multivariate linear regression analysis showed that LV mass index (β = 0.225, P = 0.012), t‐LV UR (β = 0.370, P < 0.001), LV mass index (β = 0.183, P = 0.025), MPI (β = 0.288, P < 0.001), and GLS (β = −0.385, P < 0.001) were significantly associated with MAC severity.
Conclusion
The presence and severity of MAC is associated with impaired LV systolic and diastolic functions. Therefore, preventive strategies might be taken in patients with MAC to avoid LV systolic and diastolic dysfunction.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25471693</pmid><doi>10.1111/echo.12861</doi><tpages>10</tpages></addata></record> |
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| ispartof | Echocardiography (Mount Kisco, N.Y.), 2015-09, Vol.32 (9), p.1374-1383 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Calcinosis - complications Calcinosis - diagnostic imaging Cross-Sectional Studies Female Humans left ventricular mechanical functions Male mitral annular calcification Mitral Valve - diagnostic imaging Prospective Studies Risk Factors subclinical left ventricle systolic dysfunction Treatment Outcome two-dimensional speckle tracking echocardiography Ultrasonography Ventricular Dysfunction, Left - complications Ventricular Dysfunction, Left - diagnostic imaging |
| title | Association of Mitral Annular Calcification with Left Ventricular Mechanics: A Speckle Tracking Study |
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