Impact of an experimental PRRSV and Streptococcus suis coinfection on the pharmacokinetics of ceftiofur hydrochloride after intramuscular injection in pigs
This study determined the impact of porcine reproductive and respiratory syndrome virus (PRRSV) and Streptococcus suis coinfection on the pharmacokinetic (PK) profile of ceftiofur hydrochloride in pigs after intramuscular (i.m.) injection. Eighteen clinically normal crossbred gilts were assigned by...
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| Veröffentlicht in: | Journal of veterinary pharmacology and therapeutics 2015-10, Vol.38 (5), p.475-481 |
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| creator | Day, D. N. Sparks, J. W. Karriker, L. A. Stalder, K. J. Wulf, L. W. Zhang, J. Kinyon, J. M. Stock, M. L. Gehring, R. Wang, C. Ellingson, J. Coetzee, J. F. |
| description | This study determined the impact of porcine reproductive and respiratory syndrome virus (PRRSV) and Streptococcus suis coinfection on the pharmacokinetic (PK) profile of ceftiofur hydrochloride in pigs after intramuscular (i.m.) injection. Eighteen clinically normal crossbred gilts were assigned by weight into a challenge group (10 pigs) and control group (eight pigs). Pigs in both groups received a single i.m. injection of ceftiofur hydrochloride (Excenel RTU Sterile Suspension; Zoetis) at a 5 mg/kg BW dose. Serial blood samples were collected to characterize the plasma concentration curve. After a 10 days drug washout period, the challenge group was inoculated with 2 mL of PRRSV isolate VR‐2385 (10⁵.⁷⁵ 50% tissue culture infective doses per mL) intranasally and 8 days later inoculated S. suis. When clinical disease was evident, the second PK assessment began in both challenge and control groups. Coinfected pigs demonstrated lower values of AUC and CMAX, but higher values of Cl/F and Vz/F indicating drug kinetics were altered by infection. The data from this study have implications on ceftiofur treatment regimens in diseased pigs. |
| doi_str_mv | 10.1111/jvp.12209 |
| format | Article |
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N. ; Sparks, J. W. ; Karriker, L. A. ; Stalder, K. J. ; Wulf, L. W. ; Zhang, J. ; Kinyon, J. M. ; Stock, M. L. ; Gehring, R. ; Wang, C. ; Ellingson, J. ; Coetzee, J. F.</creator><creatorcontrib>Day, D. N. ; Sparks, J. W. ; Karriker, L. A. ; Stalder, K. J. ; Wulf, L. W. ; Zhang, J. ; Kinyon, J. M. ; Stock, M. L. ; Gehring, R. ; Wang, C. ; Ellingson, J. ; Coetzee, J. F.</creatorcontrib><description>This study determined the impact of porcine reproductive and respiratory syndrome virus (PRRSV) and Streptococcus suis coinfection on the pharmacokinetic (PK) profile of ceftiofur hydrochloride in pigs after intramuscular (i.m.) injection. Eighteen clinically normal crossbred gilts were assigned by weight into a challenge group (10 pigs) and control group (eight pigs). Pigs in both groups received a single i.m. injection of ceftiofur hydrochloride (Excenel RTU Sterile Suspension; Zoetis) at a 5 mg/kg BW dose. Serial blood samples were collected to characterize the plasma concentration curve. After a 10 days drug washout period, the challenge group was inoculated with 2 mL of PRRSV isolate VR‐2385 (10⁵.⁷⁵ 50% tissue culture infective doses per mL) intranasally and 8 days later inoculated S. suis. When clinical disease was evident, the second PK assessment began in both challenge and control groups. Coinfected pigs demonstrated lower values of AUC and CMAX, but higher values of Cl/F and Vz/F indicating drug kinetics were altered by infection. The data from this study have implications on ceftiofur treatment regimens in diseased pigs.</description><identifier>ISSN: 0140-7783</identifier><identifier>EISSN: 1365-2885</identifier><identifier>DOI: 10.1111/jvp.12209</identifier><identifier>PMID: 25689130</identifier><language>eng</language><publisher>England: Blackwell Scientific Publications</publisher><subject>Animals ; Anti-Bacterial Agents - pharmacokinetics ; Anti-Bacterial Agents - therapeutic use ; Cephalosporins - pharmacokinetics ; Cephalosporins - therapeutic use ; Coinfection - drug therapy ; Coinfection - metabolism ; Coinfection - microbiology ; Coinfection - veterinary ; Coinfection - virology ; Female ; Injections, Intramuscular - veterinary ; Porcine Reproductive and Respiratory Syndrome - drug therapy ; Porcine Reproductive and Respiratory Syndrome - metabolism ; Porcine Reproductive and Respiratory Syndrome - microbiology ; Porcine respiratory and reproductive syndrome virus ; Streptococcal Infections - complications ; Streptococcal Infections - drug therapy ; Streptococcal Infections - microbiology ; Streptococcal Infections - veterinary ; Streptococcal Infections - virology ; Streptococcus suis ; Swine - metabolism ; Swine - microbiology ; Swine - virology ; Swine Diseases - drug therapy ; Swine Diseases - microbiology ; Swine Diseases - virology</subject><ispartof>Journal of veterinary pharmacology and therapeutics, 2015-10, Vol.38 (5), p.475-481</ispartof><rights>2015 John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjvp.12209$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjvp.12209$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25689130$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Day, D. N.</creatorcontrib><creatorcontrib>Sparks, J. W.</creatorcontrib><creatorcontrib>Karriker, L. A.</creatorcontrib><creatorcontrib>Stalder, K. J.</creatorcontrib><creatorcontrib>Wulf, L. W.</creatorcontrib><creatorcontrib>Zhang, J.</creatorcontrib><creatorcontrib>Kinyon, J. M.</creatorcontrib><creatorcontrib>Stock, M. L.</creatorcontrib><creatorcontrib>Gehring, R.</creatorcontrib><creatorcontrib>Wang, C.</creatorcontrib><creatorcontrib>Ellingson, J.</creatorcontrib><creatorcontrib>Coetzee, J. F.</creatorcontrib><title>Impact of an experimental PRRSV and Streptococcus suis coinfection on the pharmacokinetics of ceftiofur hydrochloride after intramuscular injection in pigs</title><title>Journal of veterinary pharmacology and therapeutics</title><addtitle>J. vet. Pharmacol. Therap</addtitle><description>This study determined the impact of porcine reproductive and respiratory syndrome virus (PRRSV) and Streptococcus suis coinfection on the pharmacokinetic (PK) profile of ceftiofur hydrochloride in pigs after intramuscular (i.m.) injection. Eighteen clinically normal crossbred gilts were assigned by weight into a challenge group (10 pigs) and control group (eight pigs). Pigs in both groups received a single i.m. injection of ceftiofur hydrochloride (Excenel RTU Sterile Suspension; Zoetis) at a 5 mg/kg BW dose. Serial blood samples were collected to characterize the plasma concentration curve. After a 10 days drug washout period, the challenge group was inoculated with 2 mL of PRRSV isolate VR‐2385 (10⁵.⁷⁵ 50% tissue culture infective doses per mL) intranasally and 8 days later inoculated S. suis. When clinical disease was evident, the second PK assessment began in both challenge and control groups. Coinfected pigs demonstrated lower values of AUC and CMAX, but higher values of Cl/F and Vz/F indicating drug kinetics were altered by infection. The data from this study have implications on ceftiofur treatment regimens in diseased pigs.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Cephalosporins - pharmacokinetics</subject><subject>Cephalosporins - therapeutic use</subject><subject>Coinfection - drug therapy</subject><subject>Coinfection - metabolism</subject><subject>Coinfection - microbiology</subject><subject>Coinfection - veterinary</subject><subject>Coinfection - virology</subject><subject>Female</subject><subject>Injections, Intramuscular - veterinary</subject><subject>Porcine Reproductive and Respiratory Syndrome - drug therapy</subject><subject>Porcine Reproductive and Respiratory Syndrome - metabolism</subject><subject>Porcine Reproductive and Respiratory Syndrome - microbiology</subject><subject>Porcine respiratory and reproductive syndrome virus</subject><subject>Streptococcal Infections - complications</subject><subject>Streptococcal Infections - drug therapy</subject><subject>Streptococcal Infections - microbiology</subject><subject>Streptococcal Infections - veterinary</subject><subject>Streptococcal Infections - virology</subject><subject>Streptococcus suis</subject><subject>Swine - metabolism</subject><subject>Swine - microbiology</subject><subject>Swine - virology</subject><subject>Swine Diseases - drug therapy</subject><subject>Swine Diseases - microbiology</subject><subject>Swine Diseases - virology</subject><issn>0140-7783</issn><issn>1365-2885</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kctuEzEARS0EoqGw4AfASzbT-jF-zBJFpZRWUDVtWFoex26czowH2wPNt_CzOE2oZcuvc-_iXgDeY3SCyzjd_B5PMCGoeQFmmHJWESnZSzBDuEaVEJIegTcpbRBCVGL8GhwRxmWDKZqBvxf9qE2GwUE9QPs42uh7O2Tdweubm8WyvK7gIkc75mCCMVOCafIJmuAHZ032YYBl5rWF41rHXpvw4AebvUk7T2NdQdwU4Xq7isGsuxD9ykLtso3QDznqfkpm6vTutjkY-gGO_j69Ba-c7pJ9d9iPwd2Xs9v51-rqx_nF_PNV5WjNm0q2DGtCEeUlgbpurTWoxa1hRmBjSNMQuaK2Zk2LnWCcixZLopGkpGE1dYIeg0973zGGX5NNWfU-Gdt1erBhSgoL1AjEWC0L-uGATm1vV2osaem4Vf8DLcDpHvjjO7t9_sdI7ZpSpSn11JT6trx-OhRFtVf4lO3js0LHB8UFFUz9_H6u5peXi1u05Gpe-I973umg9H30Sd0tCMIclUUE5fQfla6gpw</recordid><startdate>201510</startdate><enddate>201510</enddate><creator>Day, D. N.</creator><creator>Sparks, J. W.</creator><creator>Karriker, L. A.</creator><creator>Stalder, K. J.</creator><creator>Wulf, L. W.</creator><creator>Zhang, J.</creator><creator>Kinyon, J. M.</creator><creator>Stock, M. L.</creator><creator>Gehring, R.</creator><creator>Wang, C.</creator><creator>Ellingson, J.</creator><creator>Coetzee, J. F.</creator><general>Blackwell Scientific Publications</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201510</creationdate><title>Impact of an experimental PRRSV and Streptococcus suis coinfection on the pharmacokinetics of ceftiofur hydrochloride after intramuscular injection in pigs</title><author>Day, D. N. ; Sparks, J. W. ; Karriker, L. A. ; Stalder, K. J. ; Wulf, L. W. ; Zhang, J. ; Kinyon, J. M. ; Stock, M. L. ; Gehring, R. ; Wang, C. ; Ellingson, J. ; Coetzee, J. F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f3469-8b51a2303620944beec0b1bc5c71cc29928d3e459b1f75667b182a08329543f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacokinetics</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Cephalosporins - pharmacokinetics</topic><topic>Cephalosporins - therapeutic use</topic><topic>Coinfection - drug therapy</topic><topic>Coinfection - metabolism</topic><topic>Coinfection - microbiology</topic><topic>Coinfection - veterinary</topic><topic>Coinfection - virology</topic><topic>Female</topic><topic>Injections, Intramuscular - veterinary</topic><topic>Porcine Reproductive and Respiratory Syndrome - drug therapy</topic><topic>Porcine Reproductive and Respiratory Syndrome - metabolism</topic><topic>Porcine Reproductive and Respiratory Syndrome - microbiology</topic><topic>Porcine respiratory and reproductive syndrome virus</topic><topic>Streptococcal Infections - complications</topic><topic>Streptococcal Infections - drug therapy</topic><topic>Streptococcal Infections - microbiology</topic><topic>Streptococcal Infections - veterinary</topic><topic>Streptococcal Infections - virology</topic><topic>Streptococcus suis</topic><topic>Swine - metabolism</topic><topic>Swine - microbiology</topic><topic>Swine - virology</topic><topic>Swine Diseases - drug therapy</topic><topic>Swine Diseases - microbiology</topic><topic>Swine Diseases - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Day, D. N.</creatorcontrib><creatorcontrib>Sparks, J. W.</creatorcontrib><creatorcontrib>Karriker, L. A.</creatorcontrib><creatorcontrib>Stalder, K. J.</creatorcontrib><creatorcontrib>Wulf, L. W.</creatorcontrib><creatorcontrib>Zhang, J.</creatorcontrib><creatorcontrib>Kinyon, J. M.</creatorcontrib><creatorcontrib>Stock, M. L.</creatorcontrib><creatorcontrib>Gehring, R.</creatorcontrib><creatorcontrib>Wang, C.</creatorcontrib><creatorcontrib>Ellingson, J.</creatorcontrib><creatorcontrib>Coetzee, J. F.</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of veterinary pharmacology and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Day, D. N.</au><au>Sparks, J. W.</au><au>Karriker, L. A.</au><au>Stalder, K. J.</au><au>Wulf, L. W.</au><au>Zhang, J.</au><au>Kinyon, J. M.</au><au>Stock, M. L.</au><au>Gehring, R.</au><au>Wang, C.</au><au>Ellingson, J.</au><au>Coetzee, J. F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of an experimental PRRSV and Streptococcus suis coinfection on the pharmacokinetics of ceftiofur hydrochloride after intramuscular injection in pigs</atitle><jtitle>Journal of veterinary pharmacology and therapeutics</jtitle><addtitle>J. vet. Pharmacol. Therap</addtitle><date>2015-10</date><risdate>2015</risdate><volume>38</volume><issue>5</issue><spage>475</spage><epage>481</epage><pages>475-481</pages><issn>0140-7783</issn><eissn>1365-2885</eissn><abstract>This study determined the impact of porcine reproductive and respiratory syndrome virus (PRRSV) and Streptococcus suis coinfection on the pharmacokinetic (PK) profile of ceftiofur hydrochloride in pigs after intramuscular (i.m.) injection. Eighteen clinically normal crossbred gilts were assigned by weight into a challenge group (10 pigs) and control group (eight pigs). Pigs in both groups received a single i.m. injection of ceftiofur hydrochloride (Excenel RTU Sterile Suspension; Zoetis) at a 5 mg/kg BW dose. Serial blood samples were collected to characterize the plasma concentration curve. After a 10 days drug washout period, the challenge group was inoculated with 2 mL of PRRSV isolate VR‐2385 (10⁵.⁷⁵ 50% tissue culture infective doses per mL) intranasally and 8 days later inoculated S. suis. When clinical disease was evident, the second PK assessment began in both challenge and control groups. Coinfected pigs demonstrated lower values of AUC and CMAX, but higher values of Cl/F and Vz/F indicating drug kinetics were altered by infection. The data from this study have implications on ceftiofur treatment regimens in diseased pigs.</abstract><cop>England</cop><pub>Blackwell Scientific Publications</pub><pmid>25689130</pmid><doi>10.1111/jvp.12209</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - therapeutic use Cephalosporins - pharmacokinetics Cephalosporins - therapeutic use Coinfection - drug therapy Coinfection - metabolism Coinfection - microbiology Coinfection - veterinary Coinfection - virology Female Injections, Intramuscular - veterinary Porcine Reproductive and Respiratory Syndrome - drug therapy Porcine Reproductive and Respiratory Syndrome - metabolism Porcine Reproductive and Respiratory Syndrome - microbiology Porcine respiratory and reproductive syndrome virus Streptococcal Infections - complications Streptococcal Infections - drug therapy Streptococcal Infections - microbiology Streptococcal Infections - veterinary Streptococcal Infections - virology Streptococcus suis Swine - metabolism Swine - microbiology Swine - virology Swine Diseases - drug therapy Swine Diseases - microbiology Swine Diseases - virology |
| title | Impact of an experimental PRRSV and Streptococcus suis coinfection on the pharmacokinetics of ceftiofur hydrochloride after intramuscular injection in pigs |
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