The Use of Lidocaine Containing Cardioplegia in Surgery for Adult Acquired Heart Disease

ABSTRACT Background Del Nido cardioplegia, a crystalloid‐based solution with lidocaine as a key element, is given as a single dose and has been used successfully in congenital cardiac surgery. Hypothesis We retrospectively compared a lidocaine containing “modified del Nido” solution with our standard whole blood cardioplegia to investigate its safety and efficacy in adult cardiac surgery. Methods From June 1, 2013 to December 30, 2013, we used a single dose of lidocaine containing cardioplegia (LC group) in 92 consecutive operations. Propensity matching analysis was undertaken to compare the outcomes of such patients with those who underwent their surgery by the same surgeon using standard whole blood cardioplegia (WB group), n = 396. Propensity score matching yielded 79 pairs of patients. Results After propensity matching, LC and WB groups were similar in baseline operative characteristics including cross‐clamp time (LC: 65 minutes [range 54 to 89] vs. WB: 70 minutes [54 to 86], p = 0.993). Postoperative outcomes were similar including inotropic requirements (30.4% [24/72] vs. 25.3% [20/72], p