Activation of integrated provirus requires histone acetyltransferase. p300 and P/CAF are coactivators for HIV-1 Tat

A unique aspect of the retrovirus life cycle is the obligatory integration of the provirus into host cell chromosomes. Unlike viruses that do not integrate, retroviruses must conserve an ability to activate transcription from a chromatin context. Human immunodeficiency virus (HIV)-1 encodes an unusu...

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Veröffentlicht in:	The Journal of biological chemistry 1998-09, Vol.273 (38), p.24898-24905
Hauptverfasser:	Benkirane, M, Chun, R F, Xiao, H, Ogryzko, V V, Howard, B H, Nakatani, Y, Jeang, K T
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Acetyltransferases - metabolism Animals Binding Sites Cell Cycle Proteins - metabolism Chromatin - genetics Chromatin - physiology Cloning, Molecular Gene Products, tat - genetics Gene Products, tat - isolation & purification Gene Products, tat - metabolism HeLa Cells Histone Acetyltransferases HIV Long Terminal Repeat HIV-1 - enzymology HIV-1 - genetics HIV-1 - physiology Human immunodeficiency virus 1 Humans Life Cycle Stages Mice p300-CBP Transcription Factors Proviruses - genetics Proviruses - physiology Recombinant Fusion Proteins - isolation & purification Recombinant Fusion Proteins - metabolism Saccharomyces cerevisiae Proteins Sequence Deletion tat Gene Products, Human Immunodeficiency Virus Transcription Factors Virus Integration
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