Phase III trial of 5-fluorouracil and leucovorin plus either 3H1 anti-idiotype monoclonal antibody or placebo in patients with advanced colorectal cancer

Background: The monoclonal antibody 3H1 mimics the external structure of the carcinoembryonic antigen (CEA). It therefore has the potential, via the anti-idiotypic network, to stimulate immune responses to CEA that may benefit colorectal cancer patients. Patients and methods: A total of 630 patients...

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Veröffentlicht in:	Annals of oncology 2006-03, Vol.17 (3), p.437-442
Hauptverfasser:	Chong, G., Bhatnagar, A., Cunningham, D., Cosgriff, T. M., Harper, P. G., Steward, W., Bridgewater, J., Moore, M., Cassidy, J., Coleman, R., Coxon, F., Redfern, C. H., Jones, J. J., Hawkins, R., Northfelt, D., Sreedharan, S., Valone, F., Carmichael, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged anti-idiotype Antibodies, Anti-Idiotypic - administration & dosage Antibodies, Anti-Idiotypic - adverse effects Antibodies, Anti-Idiotypic - therapeutic use Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - therapeutic use antibody Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences carcinoembryonic antigen colorectal Colorectal Neoplasms - therapy Fluorouracil - administration & dosage Gastroenterology. Liver. Pancreas. Abdomen Humans Leucovorin - administration & dosage Medical sciences Middle Aged Pharmacology. Drug treatments Placebos response Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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