Successful Use of Adalimumab for Treating Pyoderma Gangrenosum with Ulcerative Colitis under Corticosteroid-tapering Conditions
A 52-year-old woman with ulcerative colitis was admitted to our hospital for an ulcerative colitis flare-up under salazosulfapyridine therapy. The symptoms improved with high-dose corticosteroids. After prednisolone was tapered to 10 mg, the frequency of diarrhea increased. The diarrhea was accompan...
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| Veröffentlicht in: | Internal Medicine 2015, Vol.54(17), pp.2167-2172 |
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| container_title | Internal Medicine |
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| creator | Sagami, Shintaro Ueno, Yoshitaka Tanaka, Shinji Nagai, Kenta Hayashi, Ryohei Chayama, Kazuaki |
| description | A 52-year-old woman with ulcerative colitis was admitted to our hospital for an ulcerative colitis flare-up under salazosulfapyridine therapy. The symptoms improved with high-dose corticosteroids. After prednisolone was tapered to 10 mg, the frequency of diarrhea increased. The diarrhea was accompanied by joint pain and a skin ulcer with abscess formation, which was diagnosed to be pyoderma gangrenosum. The patient was started on adalimumab. A positive response to the adalimumab therapy was observed after 2 weeks, during which time the ulcerative skin lesion healed completely, however, colonic mucosal healing was achieved at 2 months. Therefore, adalimumab appears to be an effective therapeutic option for patients with ulcerative colitis-associated pyoderma gangrenosum. |
| doi_str_mv | 10.2169/internalmedicine.54.4853 |
| format | Article |
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The symptoms improved with high-dose corticosteroids. After prednisolone was tapered to 10 mg, the frequency of diarrhea increased. The diarrhea was accompanied by joint pain and a skin ulcer with abscess formation, which was diagnosed to be pyoderma gangrenosum. The patient was started on adalimumab. A positive response to the adalimumab therapy was observed after 2 weeks, during which time the ulcerative skin lesion healed completely, however, colonic mucosal healing was achieved at 2 months. Therefore, adalimumab appears to be an effective therapeutic option for patients with ulcerative colitis-associated pyoderma gangrenosum.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.54.4853</identifier><identifier>PMID: 26328641</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject><![CDATA[adalimumab ; Adalimumab - administration & dosage ; Adalimumab - therapeutic use ; Adrenal Cortex Hormones - administration & dosage ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Colitis, Ulcerative - complications ; Colitis, Ulcerative - drug therapy ; Female ; Humans ; Middle Aged ; Prednisolone - administration & dosage ; pyoderma gangrenosum ; Pyoderma Gangrenosum - drug therapy ; Pyoderma Gangrenosum - etiology ; Skin Ulcer - complications ; Skin Ulcer - drug therapy ; Skin Ulcer - pathology ; Sulfasalazine - administration & dosage ; Treatment Failure ; Treatment Outcome ; ulcerative colitis]]></subject><ispartof>Internal Medicine, 2015, Vol.54(17), pp.2167-2172</ispartof><rights>2015 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-334e8b8a8a9606f2e1d53c99071e8241efc1d9ce09eb1c3c033e3bb361942f283</citedby><cites>FETCH-LOGICAL-c527t-334e8b8a8a9606f2e1d53c99071e8241efc1d9ce09eb1c3c033e3bb361942f283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26328641$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sagami, Shintaro</creatorcontrib><creatorcontrib>Ueno, Yoshitaka</creatorcontrib><creatorcontrib>Tanaka, Shinji</creatorcontrib><creatorcontrib>Nagai, Kenta</creatorcontrib><creatorcontrib>Hayashi, Ryohei</creatorcontrib><creatorcontrib>Chayama, Kazuaki</creatorcontrib><title>Successful Use of Adalimumab for Treating Pyoderma Gangrenosum with Ulcerative Colitis under Corticosteroid-tapering Conditions</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>A 52-year-old woman with ulcerative colitis was admitted to our hospital for an ulcerative colitis flare-up under salazosulfapyridine therapy. The symptoms improved with high-dose corticosteroids. After prednisolone was tapered to 10 mg, the frequency of diarrhea increased. The diarrhea was accompanied by joint pain and a skin ulcer with abscess formation, which was diagnosed to be pyoderma gangrenosum. The patient was started on adalimumab. A positive response to the adalimumab therapy was observed after 2 weeks, during which time the ulcerative skin lesion healed completely, however, colonic mucosal healing was achieved at 2 months. Therefore, adalimumab appears to be an effective therapeutic option for patients with ulcerative colitis-associated pyoderma gangrenosum.</description><subject>adalimumab</subject><subject>Adalimumab - administration & dosage</subject><subject>Adalimumab - therapeutic use</subject><subject>Adrenal Cortex Hormones - administration & dosage</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Colitis, Ulcerative - complications</subject><subject>Colitis, Ulcerative - drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Prednisolone - administration & dosage</subject><subject>pyoderma gangrenosum</subject><subject>Pyoderma Gangrenosum - drug therapy</subject><subject>Pyoderma Gangrenosum - etiology</subject><subject>Skin Ulcer - complications</subject><subject>Skin Ulcer - drug therapy</subject><subject>Skin Ulcer - pathology</subject><subject>Sulfasalazine - administration & dosage</subject><subject>Treatment Failure</subject><subject>Treatment Outcome</subject><subject>ulcerative colitis</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1rGzEQhkVpSNw0f6Ho2Mu6-tgP6RhMmxYCCSQ-C6121lHQSq6kbckpf73a2vWh5DLDoGfeEQ9CmJI1o638Yn2G6LWbYLDGelg39boWDX-HVpTXsuoYb96jFZFUVKyUC_QhpWdCuOgkO0cXrOVMtDVdodeH2RhIaZwd3ibAYcTXg3Z2mifd4zFE_BhBZ-t3-P4lDBAnjW-030XwIc0T_m3zE946A7FAvwBvgrPZJjz7wpYpZmtCKr8Ndqiy3kNcojbBDwULPn1EZ6N2Ca6O_RJtv3193Hyvbu9ufmyubyvTsC5XnNcgeqGFli1pRwZ0aLiRknQUBKspjIYO0gCR0FPDDeEceN_zlsqajUzwS_T5kLuP4ecMKavJJgPOaQ9hTop2RHLZ0b-oOKAmhpQijGof7aTji6JELfrV__pVU6tFf1n9dLwy9-XxtPjPdwHuDsBzynoHJ0Avnhy8mUy7pR5PnEjzpKMCz_8AbbGmqg</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Sagami, Shintaro</creator><creator>Ueno, Yoshitaka</creator><creator>Tanaka, Shinji</creator><creator>Nagai, Kenta</creator><creator>Hayashi, Ryohei</creator><creator>Chayama, Kazuaki</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150101</creationdate><title>Successful Use of Adalimumab for Treating Pyoderma Gangrenosum with Ulcerative Colitis under Corticosteroid-tapering Conditions</title><author>Sagami, Shintaro ; Ueno, Yoshitaka ; Tanaka, Shinji ; Nagai, Kenta ; Hayashi, Ryohei ; Chayama, Kazuaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-334e8b8a8a9606f2e1d53c99071e8241efc1d9ce09eb1c3c033e3bb361942f283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>adalimumab</topic><topic>Adalimumab - administration & dosage</topic><topic>Adalimumab - therapeutic use</topic><topic>Adrenal Cortex Hormones - administration & dosage</topic><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Colitis, Ulcerative - complications</topic><topic>Colitis, Ulcerative - drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Prednisolone - administration & dosage</topic><topic>pyoderma gangrenosum</topic><topic>Pyoderma Gangrenosum - drug therapy</topic><topic>Pyoderma Gangrenosum - etiology</topic><topic>Skin Ulcer - complications</topic><topic>Skin Ulcer - drug therapy</topic><topic>Skin Ulcer - pathology</topic><topic>Sulfasalazine - administration & dosage</topic><topic>Treatment Failure</topic><topic>Treatment Outcome</topic><topic>ulcerative colitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sagami, Shintaro</creatorcontrib><creatorcontrib>Ueno, Yoshitaka</creatorcontrib><creatorcontrib>Tanaka, Shinji</creatorcontrib><creatorcontrib>Nagai, Kenta</creatorcontrib><creatorcontrib>Hayashi, Ryohei</creatorcontrib><creatorcontrib>Chayama, Kazuaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sagami, Shintaro</au><au>Ueno, Yoshitaka</au><au>Tanaka, Shinji</au><au>Nagai, Kenta</au><au>Hayashi, Ryohei</au><au>Chayama, Kazuaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful Use of Adalimumab for Treating Pyoderma Gangrenosum with Ulcerative Colitis under Corticosteroid-tapering Conditions</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>54</volume><issue>17</issue><spage>2167</spage><epage>2172</epage><pages>2167-2172</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>A 52-year-old woman with ulcerative colitis was admitted to our hospital for an ulcerative colitis flare-up under salazosulfapyridine therapy. The symptoms improved with high-dose corticosteroids. After prednisolone was tapered to 10 mg, the frequency of diarrhea increased. The diarrhea was accompanied by joint pain and a skin ulcer with abscess formation, which was diagnosed to be pyoderma gangrenosum. The patient was started on adalimumab. A positive response to the adalimumab therapy was observed after 2 weeks, during which time the ulcerative skin lesion healed completely, however, colonic mucosal healing was achieved at 2 months. Therefore, adalimumab appears to be an effective therapeutic option for patients with ulcerative colitis-associated pyoderma gangrenosum.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>26328641</pmid><doi>10.2169/internalmedicine.54.4853</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | adalimumab Adalimumab - administration & dosage Adalimumab - therapeutic use Adrenal Cortex Hormones - administration & dosage Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - therapeutic use Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Colitis, Ulcerative - complications Colitis, Ulcerative - drug therapy Female Humans Middle Aged Prednisolone - administration & dosage pyoderma gangrenosum Pyoderma Gangrenosum - drug therapy Pyoderma Gangrenosum - etiology Skin Ulcer - complications Skin Ulcer - drug therapy Skin Ulcer - pathology Sulfasalazine - administration & dosage Treatment Failure Treatment Outcome ulcerative colitis |
| title | Successful Use of Adalimumab for Treating Pyoderma Gangrenosum with Ulcerative Colitis under Corticosteroid-tapering Conditions |
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