Focal Segmental Glomerular Sclerosis Ameliorated by Long-term Hemodialysis Therapy with Low-density Lipoprotein Apheresis
We report a case involving a 43-year-old Japanese woman with steroid-resistant focal segmental glomerular sclerosis (FSGS) and severe renal dysfunction, which was ameliorated by low-density lipoprotein apheresis (LDL-A). She had been treated with steroid therapy, but had experienced anuria for over...
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| Veröffentlicht in: | Internal Medicine 2015, Vol.54(17), pp.2213-2217 |
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| container_title | Internal Medicine |
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| creator | Araki, Hisazumi Ono, Shinya Nishizawa, Yuka Deji, Naoko Nakazawa, Jun Morita, Yoshikata Kume, Shinji Chin-Kanasaki, Masami Isshiki, Keiji Araki, Shin-ichi Arimura, Tetsuro Maegawa, Hiroshi Uzu, Takashi |
| description | We report a case involving a 43-year-old Japanese woman with steroid-resistant focal segmental glomerular sclerosis (FSGS) and severe renal dysfunction, which was ameliorated by low-density lipoprotein apheresis (LDL-A). She had been treated with steroid therapy, but had experienced anuria for over 10 weeks and required hemodialysis. She was then treated with LDL-A, which resulted in improved urinary protein excretion and renal function. Her renal function recovered after 97 days of hemodialysis therapy. This case suggests that LDL-A may represent an effective rescue treatment in patients with FSGS and long-term anuria. |
| doi_str_mv | 10.2169/internalmedicine.54.4631 |
| format | Article |
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She had been treated with steroid therapy, but had experienced anuria for over 10 weeks and required hemodialysis. She was then treated with LDL-A, which resulted in improved urinary protein excretion and renal function. Her renal function recovered after 97 days of hemodialysis therapy. This case suggests that LDL-A may represent an effective rescue treatment in patients with FSGS and long-term anuria.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.54.4631</identifier><identifier>PMID: 26328649</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>acute kidney injury ; Adrenal Cortex Hormones - administration & dosage ; Adult ; Anuria - etiology ; Drug Resistance ; Female ; focal segmental glomerular sclerosis ; Glomerulosclerosis, Focal Segmental - blood ; Glomerulosclerosis, Focal Segmental - complications ; Glomerulosclerosis, Focal Segmental - therapy ; hemodialysis ; Humans ; Kidney - metabolism ; Kidney - pathology ; LDL apheresis ; Lipoproteins, LDL - blood ; nephrotic syndrome ; Nephrotic Syndrome - blood ; Nephrotic Syndrome - etiology ; Nephrotic Syndrome - therapy ; Plasmapheresis ; Renal Dialysis ; Treatment Outcome</subject><ispartof>Internal Medicine, 2015, Vol.54(17), pp.2213-2217</ispartof><rights>2015 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-a971dc24472212e1fd11780975bf933e3ce0c4da2905a7dbbd289e6dfafd3cf53</citedby><cites>FETCH-LOGICAL-c527t-a971dc24472212e1fd11780975bf933e3ce0c4da2905a7dbbd289e6dfafd3cf53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26328649$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Araki, Hisazumi</creatorcontrib><creatorcontrib>Ono, Shinya</creatorcontrib><creatorcontrib>Nishizawa, Yuka</creatorcontrib><creatorcontrib>Deji, Naoko</creatorcontrib><creatorcontrib>Nakazawa, Jun</creatorcontrib><creatorcontrib>Morita, Yoshikata</creatorcontrib><creatorcontrib>Kume, Shinji</creatorcontrib><creatorcontrib>Chin-Kanasaki, Masami</creatorcontrib><creatorcontrib>Isshiki, Keiji</creatorcontrib><creatorcontrib>Araki, Shin-ichi</creatorcontrib><creatorcontrib>Arimura, Tetsuro</creatorcontrib><creatorcontrib>Maegawa, Hiroshi</creatorcontrib><creatorcontrib>Uzu, Takashi</creatorcontrib><title>Focal Segmental Glomerular Sclerosis Ameliorated by Long-term Hemodialysis Therapy with Low-density Lipoprotein Apheresis</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>We report a case involving a 43-year-old Japanese woman with steroid-resistant focal segmental glomerular sclerosis (FSGS) and severe renal dysfunction, which was ameliorated by low-density lipoprotein apheresis (LDL-A). She had been treated with steroid therapy, but had experienced anuria for over 10 weeks and required hemodialysis. She was then treated with LDL-A, which resulted in improved urinary protein excretion and renal function. Her renal function recovered after 97 days of hemodialysis therapy. This case suggests that LDL-A may represent an effective rescue treatment in patients with FSGS and long-term anuria.</description><subject>acute kidney injury</subject><subject>Adrenal Cortex Hormones - administration & dosage</subject><subject>Adult</subject><subject>Anuria - etiology</subject><subject>Drug Resistance</subject><subject>Female</subject><subject>focal segmental glomerular sclerosis</subject><subject>Glomerulosclerosis, Focal Segmental - blood</subject><subject>Glomerulosclerosis, Focal Segmental - complications</subject><subject>Glomerulosclerosis, Focal Segmental - therapy</subject><subject>hemodialysis</subject><subject>Humans</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>LDL apheresis</subject><subject>Lipoproteins, LDL - blood</subject><subject>nephrotic syndrome</subject><subject>Nephrotic Syndrome - blood</subject><subject>Nephrotic Syndrome - etiology</subject><subject>Nephrotic Syndrome - therapy</subject><subject>Plasmapheresis</subject><subject>Renal Dialysis</subject><subject>Treatment Outcome</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkDtv2zAQgIkgReKm_QuFxi5y-ZBEcTSCJilgIEPSmaDIk82AIlWSRqB_Hxp2PRRd7g7gdw9-CFUErynpxA_rM0Sv3ATGauth3TbrpmPkCq0Ia0TNKWuv0QoL0te0hFv0OaU3jFnPBb1Bt7RjtO8asULLQ9DKVS-wm8DnUj26MEE8OBWrF-0ghmRTtZnA2RBVBlMNS7UNfleXC6bqCaZgrHLLkXrdQ1TzUr3bvC_Me23AJ5sLb-cwx5DB-mozFwoK_gV9GpVL8PWc79Dvh5-v90_19vnx1_1mW-uW8lwrwYnRtGk4pYQCGQ0hvMeCt8MoGAOmAevGKCpwq7gZBkN7AZ0Z1WiYHlt2h76f5pYL_hwgZTnZpME55SEckiQcCyY4bkhB-xOqy7dThFHO0U4qLpJgeRQv_xUv20YexZfWb-cth6E8Xhr_mi7A8wl4S1nt4AKomG3x_N_JhB_jecWF1HsVJXj2AUoGpNU</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Araki, Hisazumi</creator><creator>Ono, Shinya</creator><creator>Nishizawa, Yuka</creator><creator>Deji, Naoko</creator><creator>Nakazawa, Jun</creator><creator>Morita, Yoshikata</creator><creator>Kume, Shinji</creator><creator>Chin-Kanasaki, Masami</creator><creator>Isshiki, Keiji</creator><creator>Araki, Shin-ichi</creator><creator>Arimura, Tetsuro</creator><creator>Maegawa, Hiroshi</creator><creator>Uzu, Takashi</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150101</creationdate><title>Focal Segmental Glomerular Sclerosis Ameliorated by Long-term Hemodialysis Therapy with Low-density Lipoprotein Apheresis</title><author>Araki, Hisazumi ; Ono, Shinya ; Nishizawa, Yuka ; Deji, Naoko ; Nakazawa, Jun ; Morita, Yoshikata ; Kume, Shinji ; Chin-Kanasaki, Masami ; Isshiki, Keiji ; Araki, Shin-ichi ; Arimura, Tetsuro ; Maegawa, Hiroshi ; Uzu, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-a971dc24472212e1fd11780975bf933e3ce0c4da2905a7dbbd289e6dfafd3cf53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>acute kidney injury</topic><topic>Adrenal Cortex Hormones - administration & dosage</topic><topic>Adult</topic><topic>Anuria - etiology</topic><topic>Drug Resistance</topic><topic>Female</topic><topic>focal segmental glomerular sclerosis</topic><topic>Glomerulosclerosis, Focal Segmental - blood</topic><topic>Glomerulosclerosis, Focal Segmental - complications</topic><topic>Glomerulosclerosis, Focal Segmental - therapy</topic><topic>hemodialysis</topic><topic>Humans</topic><topic>Kidney - metabolism</topic><topic>Kidney - pathology</topic><topic>LDL apheresis</topic><topic>Lipoproteins, LDL - blood</topic><topic>nephrotic syndrome</topic><topic>Nephrotic Syndrome - blood</topic><topic>Nephrotic Syndrome - etiology</topic><topic>Nephrotic Syndrome - therapy</topic><topic>Plasmapheresis</topic><topic>Renal Dialysis</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Araki, Hisazumi</creatorcontrib><creatorcontrib>Ono, Shinya</creatorcontrib><creatorcontrib>Nishizawa, Yuka</creatorcontrib><creatorcontrib>Deji, Naoko</creatorcontrib><creatorcontrib>Nakazawa, Jun</creatorcontrib><creatorcontrib>Morita, Yoshikata</creatorcontrib><creatorcontrib>Kume, Shinji</creatorcontrib><creatorcontrib>Chin-Kanasaki, Masami</creatorcontrib><creatorcontrib>Isshiki, Keiji</creatorcontrib><creatorcontrib>Araki, Shin-ichi</creatorcontrib><creatorcontrib>Arimura, Tetsuro</creatorcontrib><creatorcontrib>Maegawa, Hiroshi</creatorcontrib><creatorcontrib>Uzu, Takashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Araki, Hisazumi</au><au>Ono, Shinya</au><au>Nishizawa, Yuka</au><au>Deji, Naoko</au><au>Nakazawa, Jun</au><au>Morita, Yoshikata</au><au>Kume, Shinji</au><au>Chin-Kanasaki, Masami</au><au>Isshiki, Keiji</au><au>Araki, Shin-ichi</au><au>Arimura, Tetsuro</au><au>Maegawa, Hiroshi</au><au>Uzu, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Focal Segmental Glomerular Sclerosis Ameliorated by Long-term Hemodialysis Therapy with Low-density Lipoprotein Apheresis</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>54</volume><issue>17</issue><spage>2213</spage><epage>2217</epage><pages>2213-2217</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>We report a case involving a 43-year-old Japanese woman with steroid-resistant focal segmental glomerular sclerosis (FSGS) and severe renal dysfunction, which was ameliorated by low-density lipoprotein apheresis (LDL-A). She had been treated with steroid therapy, but had experienced anuria for over 10 weeks and required hemodialysis. She was then treated with LDL-A, which resulted in improved urinary protein excretion and renal function. Her renal function recovered after 97 days of hemodialysis therapy. 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| ispartof | Internal Medicine, 2015, Vol.54(17), pp.2213-2217 |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | acute kidney injury Adrenal Cortex Hormones - administration & dosage Adult Anuria - etiology Drug Resistance Female focal segmental glomerular sclerosis Glomerulosclerosis, Focal Segmental - blood Glomerulosclerosis, Focal Segmental - complications Glomerulosclerosis, Focal Segmental - therapy hemodialysis Humans Kidney - metabolism Kidney - pathology LDL apheresis Lipoproteins, LDL - blood nephrotic syndrome Nephrotic Syndrome - blood Nephrotic Syndrome - etiology Nephrotic Syndrome - therapy Plasmapheresis Renal Dialysis Treatment Outcome |
| title | Focal Segmental Glomerular Sclerosis Ameliorated by Long-term Hemodialysis Therapy with Low-density Lipoprotein Apheresis |
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