CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling

Collapsin response mediator protein 5 (CRMP5) belongs to a family of five cytosolic proteins that play a major role in nervous system development. This protein was first described in cancer-induced autoimmune processes, causing neurodegenerative disorders (paraneoplastic neurologic syndromes). CRMP5...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2015-09, Vol.75 (17), p.3519-3528
Hauptverfasser:	Moutal, Aubin, Honnorat, Jérôme, Massoma, Patrick, Désormeaux, Pauline, Bertrand, Caroline, Malleval, Céline, Watrin, Chantal, Chounlamountri, Naura, Mayeur, Marie-Eve, Besançon, Roger, Naudet, Nicolas, Magadoux, Léa, Khanna, Rajesh, Ducray, François, Meyronet, David, Thomasset, Nicole
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Animals Brain Neoplasms - genetics Brain Neoplasms - pathology Cell Line, Tumor Cell Proliferation - genetics Female Gene Expression Regulation, Neoplastic Glioblastoma - genetics Glioblastoma - pathology Humans Male Mice Middle Aged Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Receptors, Notch - genetics Receptors, Notch - metabolism Signal Transduction Survival Analysis Xenograft Model Antitumor Assays
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