Transcription Factor IIA Mutations Show Activator-specific Defects and Reveal a IIA Function Distinct from Stimulation of TBP-DNA Binding (∗)

The general transcription factor IIA (TFIIA) binds to the TATA binding protein (TBP) and mediates transcriptional activation by distinct classes of activators. To elucidate the function of TFIIA in transcriptional activation, point mutants were created in the human TFIIA-γ subunit at positions conse...

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Veröffentlicht in:	The Journal of biological chemistry 1996-05, Vol.271 (19), p.11182-11190
Hauptverfasser:	Ozer, Josef, Bolden, Arthur H., Lieberman, Paul M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Amino Acid Sequence Conserved Sequence DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - metabolism Glutathione Transferase - biosynthesis Humans Molecular Sequence Data Mutagenesis, Site-Directed Point Mutation Polymerase Chain Reaction Promoter Regions, Genetic Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - metabolism Saccharomyces cerevisiae - metabolism TATA Box TATA-Box Binding Protein Transcription Factor TFIIA Transcription Factor TFIID Transcription Factors - biosynthesis Transcription Factors - metabolism Transcriptional Activation
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