Contribution of impaired myofibril and ryanodine receptor function to prolonged low-frequency force depression after in situ stimulation in rat skeletal muscle

The aim of this study was to examine whether prolonged low-frequency force depression (PLFFD) that occurs in situ is the result of decreased myofibrillar Ca 2+ sensitivity and/or reduced sarcoplasmic reticulum (SR) Ca 2+ release. Intact rat gastrocnemius muscles were electrically stimulated via the...

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Veröffentlicht in:	Journal of muscle research and cell motility 2015-06, Vol.36 (3), p.275-286
Hauptverfasser:	Watanabe, Daiki, Kanzaki, Keita, Kuratani, Mai, Matsunaga, Satoshi, Yanaka, Noriyuki, Wada, Masanobu
Format:	Artikel
Sprache:	eng
Schlagworte:	2,2'-Dipyridyl - analogs & derivatives 2,2'-Dipyridyl - pharmacology Animal Anatomy Animals Biomedical and Life Sciences Biomedicine Caffeine - pharmacology Calcium - metabolism Cell Biology Cresols - pharmacology Disulfides - pharmacology Glutathione - metabolism Histology Life Sciences Male Morphology Muscle Contraction - drug effects Muscle Contraction - physiology Muscle Fatigue - drug effects Muscle Fatigue - physiology Muscle Fibers, Fast-Twitch - metabolism Muscle Fibers, Fast-Twitch - physiology Muscle Fibers, Slow-Twitch - metabolism Muscle Fibers, Slow-Twitch - physiology Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - physiology Myofibrils - drug effects Myofibrils - metabolism Myofibrils - physiology Original Paper Proteomics Rats Rats, Wistar Ryanodine Receptor Calcium Release Channel - metabolism Sarcoplasmic Reticulum - drug effects Sarcoplasmic Reticulum - metabolism Sarcoplasmic Reticulum - physiology Troponin I - metabolism
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