Engineering the heterologous expression of lanthipeptides in Escherichia coli by multigene assembly

Lantibiotics are an important class of ribosomally synthesised peptide antibiotics with a remarkable pharmacological potential. Structural variants of lantibiotics generated by peptide engineering in vivo are an important aspect for improving the peptide’s efficacy, stability and bioavailability as...

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Veröffentlicht in:	Applied microbiology and biotechnology 2015-08, Vol.99 (15), p.6351-6361
Hauptverfasser:	Kuthning, Anja, Mösker, Eva, Süssmuth, Roderich D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Analysis Antibiotics Antimicrobial agents Applied Genetics and Molecular Biotechnology Bacillus licheniformis bacteriocins Bacteriocins - genetics Bacteriocins - metabolism Bioavailability Biomedical and Life Sciences Biotechnology Blias Cloning Cloning, Molecular E coli engineering Enzymes Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Gene Expression Genes Genetic engineering Gram-positive bacteria heterologous gene expression Life Sciences Metabolic Engineering - methods Metabolic Networks and Pathways - genetics Microbial Genetics and Genomics Microbiology Mutagenesis Natural products peptide antibiotics Peptides Pharmaceutical industry Pharmaceutical sciences Plasmids Recombinant Proteins - genetics Recombinant Proteins - metabolism Studies translation (genetics) Yeast yields
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