Effects of palatable cafeteria diet on cognitive and noncognitive behaviors and brain neurotrophins’ levels in mice
The consumption of palatable high-fat and high-sugar foods have increased dramatically over the past years. Overconsumption of calorically dense food contributes to increasing rates of overweight and obesity that are associated with psychiatry disorders, in particular mood and anxiety disorders. Thi...
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| Veröffentlicht in: | Metabolic brain disease 2015-08, Vol.30 (4), p.1073-1082 |
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| creator | Leffa, Daniela D. Valvassori, Samira S. Varela, Roger B. Lopes-Borges, Jésica Daumann, Francine Longaretti, Luiza M. Dajori, Ana Luiza F. Quevedo, João Andrade, Vanessa M. |
| description | The consumption of palatable high-fat and high-sugar foods have increased dramatically over the past years. Overconsumption of calorically dense food contributes to increasing rates of overweight and obesity that are associated with psychiatry disorders, in particular mood and anxiety disorders. This study evaluated the impact of palatable cafeteria diet (CAF) intake on cognitive and noncognitive behaviors, as well as identified factors related to these behaviors through an evaluation of brain neurotrophic factor (BDNF, NGF, and GDNF) levels in hippocampus of mice. Male Swiss mice received two different diets during 13 weeks: standard chow (STA) and highly CAF. Posteriorly, forced swimming test (FST), tail suspension test (TST), plus-maze test (PMT), open-field tests (OFT), and object recognition task (ORT) were utilized as behavioral tests. In addition, brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and nerve growth factor (NGF) neurotrophins’ levels were evaluated in hippocampus of mice. The results demonstrated that mice from the CAF group showed a decrease in the immobility time in the FST and TST. Besides, mice in the CAF group spent more time in the open arms of the PMT. No significant differences were observed in the cognitive behaviors, which were evaluated in the OFT and ORT. In addition, the CAF group showed that BDNF and NGF protein levels increased in the hippocampus of mice. In conclusion, our data suggest that the consumption of palatable high-fat and high-sugar foods induces antidepressant- and anxiolytic-like behaviors, which can be related with BDNF and NGF expression increases in hippocampus of mice in the CAF group. |
| doi_str_mv | 10.1007/s11011-015-9682-0 |
| format | Article |
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Overconsumption of calorically dense food contributes to increasing rates of overweight and obesity that are associated with psychiatry disorders, in particular mood and anxiety disorders. This study evaluated the impact of palatable cafeteria diet (CAF) intake on cognitive and noncognitive behaviors, as well as identified factors related to these behaviors through an evaluation of brain neurotrophic factor (BDNF, NGF, and GDNF) levels in hippocampus of mice. Male Swiss mice received two different diets during 13 weeks: standard chow (STA) and highly CAF. Posteriorly, forced swimming test (FST), tail suspension test (TST), plus-maze test (PMT), open-field tests (OFT), and object recognition task (ORT) were utilized as behavioral tests. In addition, brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and nerve growth factor (NGF) neurotrophins’ levels were evaluated in hippocampus of mice. The results demonstrated that mice from the CAF group showed a decrease in the immobility time in the FST and TST. Besides, mice in the CAF group spent more time in the open arms of the PMT. No significant differences were observed in the cognitive behaviors, which were evaluated in the OFT and ORT. In addition, the CAF group showed that BDNF and NGF protein levels increased in the hippocampus of mice. In conclusion, our data suggest that the consumption of palatable high-fat and high-sugar foods induces antidepressant- and anxiolytic-like behaviors, which can be related with BDNF and NGF expression increases in hippocampus of mice in the CAF group.</description><identifier>ISSN: 0885-7490</identifier><identifier>EISSN: 1573-7365</identifier><identifier>DOI: 10.1007/s11011-015-9682-0</identifier><identifier>PMID: 25998605</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Brain - drug effects ; Brain - metabolism ; Brain-Derived Neurotrophic Factor - biosynthesis ; Cognition - drug effects ; Cognition - physiology ; Diet, High-Fat ; Dietary Sucrose - administration & dosage ; Energy Intake - physiology ; Glial Cell Line-Derived Neurotrophic Factor - biosynthesis ; Male ; Maze Learning - drug effects ; Maze Learning - physiology ; Metabolic Diseases ; Mice ; Nerve Growth Factor - biosynthesis ; Nerve Growth Factors - biosynthesis ; Neurology ; Neurosciences ; Oncology ; Research Article</subject><ispartof>Metabolic brain disease, 2015-08, Vol.30 (4), p.1073-1082</ispartof><rights>Springer Science+Business Media New York 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-936678533854fc29f22d58389d9a63287ae76930bf2a19d2f97ae088fa59c9fa3</citedby><cites>FETCH-LOGICAL-c541t-936678533854fc29f22d58389d9a63287ae76930bf2a19d2f97ae088fa59c9fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11011-015-9682-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11011-015-9682-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25998605$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leffa, Daniela D.</creatorcontrib><creatorcontrib>Valvassori, Samira S.</creatorcontrib><creatorcontrib>Varela, Roger B.</creatorcontrib><creatorcontrib>Lopes-Borges, Jésica</creatorcontrib><creatorcontrib>Daumann, Francine</creatorcontrib><creatorcontrib>Longaretti, Luiza M.</creatorcontrib><creatorcontrib>Dajori, Ana Luiza F.</creatorcontrib><creatorcontrib>Quevedo, João</creatorcontrib><creatorcontrib>Andrade, Vanessa M.</creatorcontrib><title>Effects of palatable cafeteria diet on cognitive and noncognitive behaviors and brain neurotrophins’ levels in mice</title><title>Metabolic brain disease</title><addtitle>Metab Brain Dis</addtitle><addtitle>Metab Brain Dis</addtitle><description>The consumption of palatable high-fat and high-sugar foods have increased dramatically over the past years. Overconsumption of calorically dense food contributes to increasing rates of overweight and obesity that are associated with psychiatry disorders, in particular mood and anxiety disorders. This study evaluated the impact of palatable cafeteria diet (CAF) intake on cognitive and noncognitive behaviors, as well as identified factors related to these behaviors through an evaluation of brain neurotrophic factor (BDNF, NGF, and GDNF) levels in hippocampus of mice. Male Swiss mice received two different diets during 13 weeks: standard chow (STA) and highly CAF. Posteriorly, forced swimming test (FST), tail suspension test (TST), plus-maze test (PMT), open-field tests (OFT), and object recognition task (ORT) were utilized as behavioral tests. In addition, brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and nerve growth factor (NGF) neurotrophins’ levels were evaluated in hippocampus of mice. The results demonstrated that mice from the CAF group showed a decrease in the immobility time in the FST and TST. Besides, mice in the CAF group spent more time in the open arms of the PMT. No significant differences were observed in the cognitive behaviors, which were evaluated in the OFT and ORT. In addition, the CAF group showed that BDNF and NGF protein levels increased in the hippocampus of mice. In conclusion, our data suggest that the consumption of palatable high-fat and high-sugar foods induces antidepressant- and anxiolytic-like behaviors, which can be related with BDNF and NGF expression increases in hippocampus of mice in the CAF group.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brain-Derived Neurotrophic Factor - biosynthesis</subject><subject>Cognition - drug effects</subject><subject>Cognition - physiology</subject><subject>Diet, High-Fat</subject><subject>Dietary Sucrose - administration & dosage</subject><subject>Energy Intake - physiology</subject><subject>Glial Cell Line-Derived Neurotrophic Factor - biosynthesis</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Maze Learning - physiology</subject><subject>Metabolic Diseases</subject><subject>Mice</subject><subject>Nerve Growth Factor - biosynthesis</subject><subject>Nerve Growth Factors - biosynthesis</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Oncology</subject><subject>Research Article</subject><issn>0885-7490</issn><issn>1573-7365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU1uFDEQhS0EIsPAAdggS2yy6eCf9t8yipKAFIkNrC23u5w46rEHu3skdrlGrsdJ8DCBoEiIVUn1vnqlqofQW0pOKCHqQ6WUUNoRKjojNevIM7SiQvFOcSmeoxXRWnSqN-QIvar1lhDCBTUv0RETxmhJxAot5yGAnyvOAW_d5GY3TIC9CzBDiQ6PEWacE_b5OsU57gC7NOKU02NjgBu3i7nUX9JQXEw4wVLyXPL2Jqb64-4eT7CDqeImbaKH1-hFcFOFNw91jb5enH85-9hdfb78dHZ61XnR07kzXEqlBeda9MEzExgbhebajMZJzrRyoKThZAjMUTOyYFqnHR2cMN4Ex9fo-OC7LfnbAnW2m1g9TJNLkJdqqSKG6vYK9n9Uml6R3rT9a_T-CXqbl5LaIXuKK85oLxtFD5QvudYCwW5L3Ljy3VJi9_HZQ3y2xWf38VnSZt49OC_DBsY_E7_zagA7ALVJ6RrKX6v_6foT-1yl9w</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Leffa, Daniela D.</creator><creator>Valvassori, Samira S.</creator><creator>Varela, Roger B.</creator><creator>Lopes-Borges, Jésica</creator><creator>Daumann, Francine</creator><creator>Longaretti, Luiza M.</creator><creator>Dajori, Ana Luiza F.</creator><creator>Quevedo, João</creator><creator>Andrade, Vanessa M.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150801</creationdate><title>Effects of palatable cafeteria diet on cognitive and noncognitive behaviors and brain neurotrophins’ levels in mice</title><author>Leffa, Daniela D. ; 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Overconsumption of calorically dense food contributes to increasing rates of overweight and obesity that are associated with psychiatry disorders, in particular mood and anxiety disorders. This study evaluated the impact of palatable cafeteria diet (CAF) intake on cognitive and noncognitive behaviors, as well as identified factors related to these behaviors through an evaluation of brain neurotrophic factor (BDNF, NGF, and GDNF) levels in hippocampus of mice. Male Swiss mice received two different diets during 13 weeks: standard chow (STA) and highly CAF. Posteriorly, forced swimming test (FST), tail suspension test (TST), plus-maze test (PMT), open-field tests (OFT), and object recognition task (ORT) were utilized as behavioral tests. In addition, brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and nerve growth factor (NGF) neurotrophins’ levels were evaluated in hippocampus of mice. The results demonstrated that mice from the CAF group showed a decrease in the immobility time in the FST and TST. Besides, mice in the CAF group spent more time in the open arms of the PMT. No significant differences were observed in the cognitive behaviors, which were evaluated in the OFT and ORT. In addition, the CAF group showed that BDNF and NGF protein levels increased in the hippocampus of mice. In conclusion, our data suggest that the consumption of palatable high-fat and high-sugar foods induces antidepressant- and anxiolytic-like behaviors, which can be related with BDNF and NGF expression increases in hippocampus of mice in the CAF group.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>25998605</pmid><doi>10.1007/s11011-015-9682-0</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals Biochemistry Biomedical and Life Sciences Biomedicine Brain - drug effects Brain - metabolism Brain-Derived Neurotrophic Factor - biosynthesis Cognition - drug effects Cognition - physiology Diet, High-Fat Dietary Sucrose - administration & dosage Energy Intake - physiology Glial Cell Line-Derived Neurotrophic Factor - biosynthesis Male Maze Learning - drug effects Maze Learning - physiology Metabolic Diseases Mice Nerve Growth Factor - biosynthesis Nerve Growth Factors - biosynthesis Neurology Neurosciences Oncology Research Article |
| title | Effects of palatable cafeteria diet on cognitive and noncognitive behaviors and brain neurotrophins’ levels in mice |
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