Combining immunotherapy with radiation for the treatment of glioblastoma
Glioblastoma is a devastating cancer with universally poor outcomes in spite of current standard multimodal therapy. Immunotherapy is an attractive new treatment modality given its potential for exquisite specificity and its favorable side effect profile; however, clinical trials of immunotherapy in...
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| Veröffentlicht in: | Journal of neuro-oncology 2015-07, Vol.123 (3), p.459-464 |
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| container_end_page | 464 |
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| container_issue | 3 |
| container_start_page | 459 |
| container_title | Journal of neuro-oncology |
| container_volume | 123 |
| creator | Chow, Kevin K. H. Hara, Wendy Lim, Michael Li, Gordon |
| description | Glioblastoma is a devastating cancer with universally poor outcomes in spite of current standard multimodal therapy. Immunotherapy is an attractive new treatment modality given its potential for exquisite specificity and its favorable side effect profile; however, clinical trials of immunotherapy in GBM have thus far shown modest benefit. Optimally combining radiation with immunotherapy may be the key to unlocking the potential of both therapies given the evidence that radiation can enhance anti-tumor immunity. Here we review this evidence and discuss considerations for combined therapy. |
| doi_str_mv | 10.1007/s11060-015-1762-9 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0167-594X |
| ispartof | Journal of neuro-oncology, 2015-07, Vol.123 (3), p.459-464 |
| issn | 0167-594X 1573-7373 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1709189807 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Brain Neoplasms - immunology Brain Neoplasms - therapy Combined Modality Therapy Editors' Invited Manuscript Glioblastoma - immunology Glioblastoma - therapy Humans Immunotherapy - methods Medicine Medicine & Public Health Neurology Oncology Radiotherapy - methods |
| title | Combining immunotherapy with radiation for the treatment of glioblastoma |
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