Identification of two new phenathrenones and a saponin as antiprotozoal constituents of Drypetes gerrardii

•HPLC-based activity profiling for targeted discovery of antiprotozoal compounds.•Two new phenanthrenones with high antiplasmodial activity in vitro activity were identified.•A monodesmosidic saponin was responsible for the trypanocidal activity of a MeOH extract. In an in vitro screen of 206 extrac...

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Veröffentlicht in:	Phytochemistry letters 2014-12, Vol.10, p.cxxxiii-cxl
Hauptverfasser:	Hata, Yoshie, De Mieri, Maria, Ebrahimi, Samad Nejad, Mokoka, Tsholofelo, Fouche, Gerda, Kaiser, Marcel, Brun, Reto, Potterat, Olivier, Hamburger, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiprotozoal Drypetes Drypetes gerrardii HPLC-based activity profiling Leishmania donovani Phenanthrenones Plasmodium berghei Plasmodium falciparum Putranjivaceae Trypanosoma brucei rhodesiense
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