Structure-Activity Relationships of Novel Salicylaldehyde Isonicotinoyl Hydrazone (SIH) Analogs: Iron Chelation, Anti-Oxidant and Cytotoxic Properties: e112059

Salicylaldehyde isonicotinoyl hydrazone (SIH) is a lipophilic, tridentate iron chelator with marked anti-oxidant and modest cytotoxic activity against neoplastic cells. However, it has poor stability in an aqueous environment due to the rapid hydrolysis of its hydrazone bond. In this study, we synth...

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Veröffentlicht in:	PloS one 2014-11, Vol.9 (11)
Hauptverfasser:	Potuckova, Eliska, Hruskova, Katerina, Bures, Jan, Kovarikova, Petra, Spirkova, Iva A, Pravdikova, Katerina, Kolbabova, Lucie, Hergeselova, Tereza, Haskova, Pavlina, Jansova, Hana
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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