Peritoneal Delivery of Sodium Pyrophosphate Blocks the Progression of Pre-existing Vascular Calcification in Uremic Apolipoprotein-E Knockout Mice

Chronic kidney disease (CKD) is generally associated with disturbances of mineral and bone metabolism. They contribute to the development of vascular calcification (VC), a strong, independent predictor of cardiovascular risk. Pyrophosphate (PPi), an endogenous inhibitor of hydroxyapatite formation,...

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Veröffentlicht in:	Calcified tissue international 2015-08, Vol.97 (2), p.179-192
Hauptverfasser:	de Oliveira, Rodrigo B., Louvet, Loïc, Riser, Bruce L., Barreto, Fellype C., Benchitrit, Joyce, Rezg, Raja, Poirot, Sabrina, Jorgetti, Vanda, Drüeke, Tilman B., Massy, Ziad A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins E - deficiency Biochemistry Biomedical and Life Sciences Bone density Cell Biology Diphosphates - administration & dosage Disease Models, Animal Disease Progression Endocrinology Hydroxyapatite Infusions, Parenteral Kidney diseases Life Sciences Mice Mice, Knockout Minerals Original Research Orthopedics Peritoneal dialysis Proteins Renal Insufficiency, Chronic - complications Uremia - complications Vascular Calcification - pathology Vascular Calcification - prevention & control
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