Lack of polymorphism in human interleukin-2 gene among malarial patients from district Bannu, Pakistan
Inflammatory cytokines play an important role in human immune responses to malarial disease. However, role of these mediators in disease pathogenesis and the relationship between host and injury remain unclear. This study was aimed at finding out polymorphism in human Interleukin-2 gene among malari...
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| Veröffentlicht in: | International journal of agriculture and biology 2010-11, Vol.12 (6), p.961-963 |
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| creator | Ajab, Z. (Quaid-i-Azam Univ., Islamabad (Pakistan). Dept. of Biochemistry) Khatoon, L. (University of Agriculture, Faisalabad (Pakistan). Dept. of Chemistry and Biochemistry) Malik, S.A. (Quaid-i-Azam Univ., Islamabad (Pakistan). Dept. of Biochemistry) Majeed, Z Ajab, H |
| description | Inflammatory cytokines play an important role in human immune responses to malarial disease. However, role of these mediators in disease pathogenesis and the relationship between host and injury remain unclear. This study was aimed at finding out polymorphism in human Interleukin-2 gene among malarial patients. Blood samples were collected from 122 patients suffering from malaria from Malaria Control Program operating in women and children District Head Quarter, Hospital at Bannu, Pakistan during summer 2007. Isolated human DNA was amplified by PCR using 3 exons of human IL-2 gene. All PCR products were of the same size as that of exon deduced from gene bank thus showing lack of polymorphism in Human Interleukin-2 gene. It was concluded that there are some invariant allele copies prevalently associated as a result of static and reduced genetic drift among population of district Bannu, Pakistan. |
| format | Article |
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(Quaid-i-Azam Univ., Islamabad (Pakistan). Dept. of Biochemistry) ; Khatoon, L. (University of Agriculture, Faisalabad (Pakistan). Dept. of Chemistry and Biochemistry) ; Malik, S.A. (Quaid-i-Azam Univ., Islamabad (Pakistan). Dept. of Biochemistry) ; Majeed, Z ; Ajab, H</creator><creatorcontrib>Ajab, Z. (Quaid-i-Azam Univ., Islamabad (Pakistan). Dept. of Biochemistry) ; Khatoon, L. (University of Agriculture, Faisalabad (Pakistan). Dept. of Chemistry and Biochemistry) ; Malik, S.A. (Quaid-i-Azam Univ., Islamabad (Pakistan). Dept. of Biochemistry) ; Majeed, Z ; Ajab, H</creatorcontrib><description>Inflammatory cytokines play an important role in human immune responses to malarial disease. However, role of these mediators in disease pathogenesis and the relationship between host and injury remain unclear. This study was aimed at finding out polymorphism in human Interleukin-2 gene among malarial patients. Blood samples were collected from 122 patients suffering from malaria from Malaria Control Program operating in women and children District Head Quarter, Hospital at Bannu, Pakistan during summer 2007. Isolated human DNA was amplified by PCR using 3 exons of human IL-2 gene. All PCR products were of the same size as that of exon deduced from gene bank thus showing lack of polymorphism in Human Interleukin-2 gene. 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Blood samples were collected from 122 patients suffering from malaria from Malaria Control Program operating in women and children District Head Quarter, Hospital at Bannu, Pakistan during summer 2007. Isolated human DNA was amplified by PCR using 3 exons of human IL-2 gene. All PCR products were of the same size as that of exon deduced from gene bank thus showing lack of polymorphism in Human Interleukin-2 gene. It was concluded that there are some invariant allele copies prevalently associated as a result of static and reduced genetic drift among population of district Bannu, Pakistan.</description><subject>ELECTROPHORESIS</subject><subject>GENES</subject><subject>GENETIC POLYMORPHISM</subject><subject>HUMAN DISEASES</subject><subject>IMMUNE RESPONSE</subject><subject>INTERLEUKINS</subject><subject>MALARIA</subject><subject>PAKISTAN</subject><issn>1560-8530</issn><issn>1814-9596</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNotUEtLxDAYLKLgsu5PEHL0YOHLo2161MUXLrgHPZfPNNmNm0dN2oP_3oAOAzMMwxzmrFpRSUXdN317XnzTQi0bDpfVJucvKBDAeoBVZXaoTiQaMkX342OajjZ7YgM5Lh5DMbNOTi8nG2pGDjpogj6GA_HoMFl0ZMLZ6jBnYlL0ZLR5TlbN5B5DWG7JHk8lwXBVXRh0WW_-dV19PD68b5_r3dvTy_ZuVxtGYa71OEquFOOfyA0XQjeCKpRjjxo4MmiVpB0awVspoFBpJTrDkTcKhYKOr6ubv90pxe9F53nwNivtHAYdlzzQDnoqOYOmVK__qgbjgIdk87B_ZUBpeUf2Hf8FR4xfpQ</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Ajab, Z. 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(Quaid-i-Azam Univ., Islamabad (Pakistan). Dept. of Biochemistry)</au><au>Khatoon, L. (University of Agriculture, Faisalabad (Pakistan). Dept. of Chemistry and Biochemistry)</au><au>Malik, S.A. (Quaid-i-Azam Univ., Islamabad (Pakistan). Dept. of Biochemistry)</au><au>Majeed, Z</au><au>Ajab, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of polymorphism in human interleukin-2 gene among malarial patients from district Bannu, Pakistan</atitle><jtitle>International journal of agriculture and biology</jtitle><date>2010-11-01</date><risdate>2010</risdate><volume>12</volume><issue>6</issue><spage>961</spage><epage>963</epage><pages>961-963</pages><issn>1560-8530</issn><eissn>1814-9596</eissn><abstract>Inflammatory cytokines play an important role in human immune responses to malarial disease. However, role of these mediators in disease pathogenesis and the relationship between host and injury remain unclear. 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| ispartof | International journal of agriculture and biology, 2010-11, Vol.12 (6), p.961-963 |
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| subjects | ELECTROPHORESIS GENES GENETIC POLYMORPHISM HUMAN DISEASES IMMUNE RESPONSE INTERLEUKINS MALARIA PAKISTAN |
| title | Lack of polymorphism in human interleukin-2 gene among malarial patients from district Bannu, Pakistan |
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