A Novel Anti-Cancer Agent, 1-(3,5-Dimethoxyphenyl)-4-[(6-Fluoro-2-Methoxyquinoxalin-3-yl)Aminocarbonyl] Piperazine (RX-5902), Interferes With β-Catenin Function Through Y593 Phospho-p68 RNA Helicase

ABSTRACT 1‐(3,5‐Dimethoxyphenyl)‐4‐[(6‐fluoro‐2‐methoxyquinoxalin‐3‐yl)aminocarbonyl] piperazine (RX‐5902) exhibits strong growth inhibition in various human cancer cell lines with IC50 values ranging between 10 and 20 nM. In this study, we demonstrate that p68 RNA helicase is a cellular target of R...

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Veröffentlicht in:	Journal of cellular biochemistry 2015-08, Vol.116 (8), p.1595-1601
Hauptverfasser:	Kost, Gina Chun, Yang, Mi Young, Li, Liangwei, Zhang, Yinwei, Liu, Chia-yi, Kim, Deog Joong, Ahn, Chang-Ho, Lee, Young Bok, Liu, Zhi-Ren
Format:	Artikel
Sprache:	eng
Schlagworte:	ANTI-CANCER Antineoplastic Agents - pharmacology beta Catenin - metabolism Binding Binding Sites - drug effects Cancer Catenin Cell Line, Tumor Cyclin D1 DEAD-box RNA Helicases - chemistry DEAD-box RNA Helicases - metabolism DNA helicase Gene expression Humans Myc protein Neoplasms - drug therapy Neoplasms - metabolism p68 RNA HELICASE PHOSPHO-p68 Phosphorylation Piperazine Piperazines - pharmacology Protein Binding - drug effects Quinoxalines - pharmacology Ribonucleic acid RNA RNA helicase RX-5902 Signal Transduction - drug effects Tumor cell lines
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