Chronic Metformin Preconditioning Provides Neuroprotection via Suppression of NF-κB-Mediated Inflammatory Pathway in Rats with Permanent Cerebral Ischemia

Accumulating evidence suggests that chronic metformin preconditioning offers potent neuroprotective effects against ischemic stroke. However, the underlying mechanisms remain largely unknown. In this study, we tested the hypothesis that chronic preconditioning with metformin conferred neuroprotectio...

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Veröffentlicht in:	Molecular neurobiology 2015-08, Vol.52 (1), p.375-385
Hauptverfasser:	Zhu, Xi-Chen, Jiang, Teng, Zhang, Qiao-Quan, Cao, Lei, Tan, Meng-Shan, Wang, Hui-Fu, Ding, Zheng-Zheng, Tan, Lan, Yu, Jin-Tai
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Astrocytes - drug effects Astrocytes - metabolism Astrocytes - pathology Biomedical and Life Sciences Biomedicine Brain - drug effects Brain - metabolism Brain - pathology Brain Ischemia - complications Brain Ischemia - drug therapy Brain Ischemia - pathology Calcium-Binding Proteins - metabolism Cell Biology Cytokines - genetics Cytokines - metabolism Glial Fibrillary Acidic Protein - metabolism Infarction, Middle Cerebral Artery - complications Infarction, Middle Cerebral Artery - drug therapy Inflammation - complications Inflammation - drug therapy Inflammation - pathology Inflammation Mediators - metabolism Male Metformin - pharmacology Metformin - therapeutic use Microfilament Proteins - metabolism Microglia - drug effects Microglia - metabolism Microglia - pathology Neurobiology Neurology Neuroprotection - drug effects Neurosciences NF-kappa B - metabolism Rats, Sprague-Dawley RNA, Messenger - genetics RNA, Messenger - metabolism Stroke - complications Stroke - drug therapy Stroke - pathology
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