Enhanced nonsynaptic epileptiform activity in the dentate gyrus after kainate-induced status epilepticus

Highlights • NEA enhancement in the dentate gyrus is associated with increased neuronal NKCC1. • NEA suppression in CA1 is related to severe neuronal loss and glial proliferation. • NKCC1 blockage confirmed that the NKCC1 increase contributed to NEA changes in DG.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2015-09, Vol.303, p.59-72
Hauptverfasser:	Nogueira, G.S, Santos, L.E.C, Rodrigues, A.M, Scorza, C.A, Scorza, F.A, Cavalheiro, E.A, de Almeida, A.-C.G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - drug effects Astrocytes - physiology CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - metabolism CA1 Region, Hippocampal - physiopathology cation-chloride cotransporters Cell Count dentate gyrus Dentate Gyrus - drug effects Dentate Gyrus - metabolism Dentate Gyrus - physiopathology Disease Models, Animal epilepsy Excitatory Amino Acid Agonists - pharmacology K Cl- Cotransporters kainate model Kainic Acid - pharmacology Male Microglia - drug effects Microglia - physiology Neurology non-synaptic epileptiform activity Pyramidal Cells - drug effects Pyramidal Cells - metabolism Pyramidal Cells - physiology Rats, Wistar Solute Carrier Family 12, Member 2 - metabolism Status Epilepticus - chemically induced Status Epilepticus - physiopathology Symporters - metabolism
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Beschreibung
Zusammenfassung:	Highlights • NEA enhancement in the dentate gyrus is associated with increased neuronal NKCC1. • NEA suppression in CA1 is related to severe neuronal loss and glial proliferation. • NKCC1 blockage confirmed that the NKCC1 increase contributed to NEA changes in DG.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.06.057