Efficacy of Crosslinking on Tailoring In Vivo Biodegradability of Fibro-Porous Decellularized Extracellular Matrix and Restoration of Native Tissue Structure: A Quantitative Study using Stereology Methods

Cholecyst‐derived extracellular matrix (CEM) is a fibro‐porous decellularized serosal layer of porcine gall‐bladder. CEM loses 90% of its weight at 48 h of in vitro collagenase digestion, but takes two months to be completely resorbed in vivo. Carbodiimide (EDC) crosslinking helps tailoring CEM'...

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Veröffentlicht in:	Macromolecular bioscience 2014-02, Vol.14 (2), p.244-256
Hauptverfasser:	Burugapalli, Krishna, Chan, Jeffrey C. Y., Kelly, John L., Pandit, Abhay S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatibility biodegradation Biomedical materials Carbodiimides - chemistry cholecyst-derived extracellular matrix Collagenases - metabolism Cross-Linking Reagents - chemistry Crosslinking Digestion Extracellular Matrix - chemistry Extracellular Matrix - metabolism Gallbladder - chemistry Implants, Experimental In vitro testing In vivo testing In vivo tests Porosity Rats Rats, Sprague-Dawley Restoration stereology Surgical implants Swine tissue-implant interactions
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