Insulinoma in a Patient with Chronic Renal Failure due to Type 2 Diabetes Mellitus Treated Effectively with Diazoxide
A 63-year-old man was diagnosed with diabetes mellitus at 42 years of age. He subsequently exhibited poor blood glucose control for a prolonged period, and his renal failure worsened. He therefore underwent hemodialysis and abdominal magnetic resonance imaging, which revealed a mass in the pancreati...
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| Veröffentlicht in: | Internal Medicine 2015, Vol.54(6), pp.621-625 |
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| container_title | Internal Medicine |
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| creator | Shimizu, Masanori Suzuki, Kunihiro Tsuchida, Kohei Kojima, Masaru Hiraishi, Hideyuki Aso, Yoshimasa |
| description | A 63-year-old man was diagnosed with diabetes mellitus at 42 years of age. He subsequently exhibited poor blood glucose control for a prolonged period, and his renal failure worsened. He therefore underwent hemodialysis and abdominal magnetic resonance imaging, which revealed a mass in the pancreatic tail. The immunoreactive insulin and C-peptide immunoreactivity levels were significantly elevated, and the results of a fasting test led to a diagnosis of insulinoma. The patient received treatment with oral diazoxide and continuous glucose monitoring (CGM), which resulted in the resolution of the hypoglycemia. This is a rare case of renal failure in which the CGM findings showed improvements in the blood glucose level after diazoxide administration. |
| doi_str_mv | 10.2169/internalmedicine.54.3621 |
| format | Article |
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He subsequently exhibited poor blood glucose control for a prolonged period, and his renal failure worsened. He therefore underwent hemodialysis and abdominal magnetic resonance imaging, which revealed a mass in the pancreatic tail. The immunoreactive insulin and C-peptide immunoreactivity levels were significantly elevated, and the results of a fasting test led to a diagnosis of insulinoma. The patient received treatment with oral diazoxide and continuous glucose monitoring (CGM), which resulted in the resolution of the hypoglycemia. This is a rare case of renal failure in which the CGM findings showed improvements in the blood glucose level after diazoxide administration.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.54.3621</identifier><identifier>PMID: 25786453</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Antihypertensive Agents - therapeutic use ; Biomarkers, Tumor - blood ; Blood Glucose - metabolism ; C-Peptide - blood ; chronic renal failure ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; diazoxide ; Diazoxide - therapeutic use ; Humans ; Hypoglycemia - blood ; Hypoglycemia - etiology ; Hypoglycemia - prevention & control ; Insulin - blood ; insulinoma ; Insulinoma - complications ; Kidney Failure, Chronic - drug therapy ; Kidney Failure, Chronic - etiology ; Male ; Middle Aged ; Pancreatic Neoplasms - complications ; Renal Dialysis ; Treatment Outcome ; type 2 diabetes ; Vasodilator Agents - therapeutic use</subject><ispartof>Internal Medicine, 2015, Vol.54(6), pp.621-625</ispartof><rights>2015 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c559t-73fa83794a3659721c7c1504e2aa05dd1fb98b237c1ee0563fc78f0de879fe273</citedby><cites>FETCH-LOGICAL-c559t-73fa83794a3659721c7c1504e2aa05dd1fb98b237c1ee0563fc78f0de879fe273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25786453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimizu, Masanori</creatorcontrib><creatorcontrib>Suzuki, Kunihiro</creatorcontrib><creatorcontrib>Tsuchida, Kohei</creatorcontrib><creatorcontrib>Kojima, Masaru</creatorcontrib><creatorcontrib>Hiraishi, Hideyuki</creatorcontrib><creatorcontrib>Aso, Yoshimasa</creatorcontrib><title>Insulinoma in a Patient with Chronic Renal Failure due to Type 2 Diabetes Mellitus Treated Effectively with Diazoxide</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>A 63-year-old man was diagnosed with diabetes mellitus at 42 years of age. He subsequently exhibited poor blood glucose control for a prolonged period, and his renal failure worsened. He therefore underwent hemodialysis and abdominal magnetic resonance imaging, which revealed a mass in the pancreatic tail. The immunoreactive insulin and C-peptide immunoreactivity levels were significantly elevated, and the results of a fasting test led to a diagnosis of insulinoma. The patient received treatment with oral diazoxide and continuous glucose monitoring (CGM), which resulted in the resolution of the hypoglycemia. This is a rare case of renal failure in which the CGM findings showed improvements in the blood glucose level after diazoxide administration.</description><subject>Antihypertensive Agents - therapeutic use</subject><subject>Biomarkers, Tumor - blood</subject><subject>Blood Glucose - metabolism</subject><subject>C-Peptide - blood</subject><subject>chronic renal failure</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>diazoxide</subject><subject>Diazoxide - therapeutic use</subject><subject>Humans</subject><subject>Hypoglycemia - blood</subject><subject>Hypoglycemia - etiology</subject><subject>Hypoglycemia - prevention & control</subject><subject>Insulin - blood</subject><subject>insulinoma</subject><subject>Insulinoma - complications</subject><subject>Kidney Failure, Chronic - drug therapy</subject><subject>Kidney Failure, Chronic - etiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pancreatic Neoplasms - complications</subject><subject>Renal Dialysis</subject><subject>Treatment Outcome</subject><subject>type 2 diabetes</subject><subject>Vasodilator Agents - therapeutic use</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9vEzEQxS0EoqHwFZCPXDb1n7W9PqLQQqVCUZWeLcc7Jq423mB7C-HT11FCDgipl7Fk_-Y9zzyEMCVzRqW-CLFAinbYQB9ciDAX7ZxLRl-gGeWtbhTj4iWaEU27htVyht7k_EAI75Rmr9EZE6qTreAzNF3HPA0hjhuLQ8QWf7clQCz4VyhrvFinMQaH76Ca4SsbhikB7ifAZcTL3RYww5-CXUGBjL_CMIQyZbxMYAv0-NJ7cCU8wrA7yFX0z_g79PAWvfJ2yPDueJ6j-6vL5eJLc3P7-Xrx8aZxQujSKO5tx5VuLZdCK0adclSQFpi1RPQ99SvdrRivtwBESO6d6jzpoY7pgSl-jj4cdLdp_DlBLmYTsqv_tBHGKRuq6ooUb6l4HpVSUMY0kxXtDqhLY84JvNmmsLFpZygx-3zMv_kY0Zp9PrX1_dFlWtXHU-PfQCrw7QA85GJ_wAmwqQQ3wH-V5b4cHU6gW9tkIPInc42uiA</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Shimizu, Masanori</creator><creator>Suzuki, Kunihiro</creator><creator>Tsuchida, Kohei</creator><creator>Kojima, Masaru</creator><creator>Hiraishi, Hideyuki</creator><creator>Aso, Yoshimasa</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20150101</creationdate><title>Insulinoma in a Patient with Chronic Renal Failure due to Type 2 Diabetes Mellitus Treated Effectively with Diazoxide</title><author>Shimizu, Masanori ; Suzuki, Kunihiro ; Tsuchida, Kohei ; Kojima, Masaru ; Hiraishi, Hideyuki ; Aso, Yoshimasa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c559t-73fa83794a3659721c7c1504e2aa05dd1fb98b237c1ee0563fc78f0de879fe273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Antihypertensive Agents - therapeutic use</topic><topic>Biomarkers, Tumor - blood</topic><topic>Blood Glucose - metabolism</topic><topic>C-Peptide - blood</topic><topic>chronic renal failure</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>diazoxide</topic><topic>Diazoxide - therapeutic use</topic><topic>Humans</topic><topic>Hypoglycemia - blood</topic><topic>Hypoglycemia - etiology</topic><topic>Hypoglycemia - prevention & control</topic><topic>Insulin - blood</topic><topic>insulinoma</topic><topic>Insulinoma - complications</topic><topic>Kidney Failure, Chronic - drug therapy</topic><topic>Kidney Failure, Chronic - etiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pancreatic Neoplasms - complications</topic><topic>Renal Dialysis</topic><topic>Treatment Outcome</topic><topic>type 2 diabetes</topic><topic>Vasodilator Agents - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shimizu, Masanori</creatorcontrib><creatorcontrib>Suzuki, Kunihiro</creatorcontrib><creatorcontrib>Tsuchida, Kohei</creatorcontrib><creatorcontrib>Kojima, Masaru</creatorcontrib><creatorcontrib>Hiraishi, Hideyuki</creatorcontrib><creatorcontrib>Aso, Yoshimasa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimizu, Masanori</au><au>Suzuki, Kunihiro</au><au>Tsuchida, Kohei</au><au>Kojima, Masaru</au><au>Hiraishi, Hideyuki</au><au>Aso, Yoshimasa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulinoma in a Patient with Chronic Renal Failure due to Type 2 Diabetes Mellitus Treated Effectively with Diazoxide</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>54</volume><issue>6</issue><spage>621</spage><epage>625</epage><pages>621-625</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>A 63-year-old man was diagnosed with diabetes mellitus at 42 years of age. He subsequently exhibited poor blood glucose control for a prolonged period, and his renal failure worsened. He therefore underwent hemodialysis and abdominal magnetic resonance imaging, which revealed a mass in the pancreatic tail. The immunoreactive insulin and C-peptide immunoreactivity levels were significantly elevated, and the results of a fasting test led to a diagnosis of insulinoma. The patient received treatment with oral diazoxide and continuous glucose monitoring (CGM), which resulted in the resolution of the hypoglycemia. This is a rare case of renal failure in which the CGM findings showed improvements in the blood glucose level after diazoxide administration.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>25786453</pmid><doi>10.2169/internalmedicine.54.3621</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Internal Medicine, 2015, Vol.54(6), pp.621-625 |
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| subjects | Antihypertensive Agents - therapeutic use Biomarkers, Tumor - blood Blood Glucose - metabolism C-Peptide - blood chronic renal failure Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications diazoxide Diazoxide - therapeutic use Humans Hypoglycemia - blood Hypoglycemia - etiology Hypoglycemia - prevention & control Insulin - blood insulinoma Insulinoma - complications Kidney Failure, Chronic - drug therapy Kidney Failure, Chronic - etiology Male Middle Aged Pancreatic Neoplasms - complications Renal Dialysis Treatment Outcome type 2 diabetes Vasodilator Agents - therapeutic use |
| title | Insulinoma in a Patient with Chronic Renal Failure due to Type 2 Diabetes Mellitus Treated Effectively with Diazoxide |
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