Preventive Effect of Cecropia pachystachya Against Ketamine-Induced Manic Behavior and Oxidative Stress in Rats
Cecropia species are widely used in traditional medicine by its anti-diabetic, anti-hypertensive and anti-inflammatory properties. In the present study, we investigated the neuroprotective and antioxidant effects of the crude aqueous extract from Cecropia pachystachya leaves in a rat model of mania...
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| Veröffentlicht in: | Neurochemical research 2015-07, Vol.40 (7), p.1421-1430 |
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| creator | Gazal, Marta Kaufmann, Fernanda N. Acosta, Bruna A. Oliveira, Pathise Souto Valente, Matheus R. Ortmann, Caroline Flach Sturbelle, Régis Lencina, Claiton L. Stefanello, Francieli M. Kaster, Manuella P. Reginatto, Flávio Henrique Ghisleni, Gabriele |
| description | Cecropia
species are widely used in traditional medicine by its anti-diabetic, anti-hypertensive and anti-inflammatory properties. In the present study, we investigated the neuroprotective and antioxidant effects of the crude aqueous extract from
Cecropia pachystachya
leaves in a rat model of mania induced by ketamine. The results indicated that ketamine treatment (25 mg/kg i.p., for 8 days) induced hyperlocomotion in the open-field test and oxidative damage in prefrontal cortex and hippocampus, evaluated by increased lipid peroxidation, carbonyl protein formation and decreased total thiol content. Moreover, ketamine treatment reduced the activity of the antioxidant enzymes superoxide dismutase and catalase in hippocampus. Pretreatment of rats with
C. pachystachya
aqueous extract (200 and 400 mg/kg p.o., for 14 days) or with lithium chloride (45 mg/kg p.o., for 14 days, used as a positive control) prevented both behavioral and pro-oxidant effects of ketamine. These findings suggest that
C. pachystachya
might be a useful tool for preventive intervention in bipolar disorder, reducing the episode relapse and the oxidative damage associated with the manic phase of this disorder . |
| doi_str_mv | 10.1007/s11064-015-1610-5 |
| format | Article |
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species are widely used in traditional medicine by its anti-diabetic, anti-hypertensive and anti-inflammatory properties. In the present study, we investigated the neuroprotective and antioxidant effects of the crude aqueous extract from
Cecropia pachystachya
leaves in a rat model of mania induced by ketamine. The results indicated that ketamine treatment (25 mg/kg i.p., for 8 days) induced hyperlocomotion in the open-field test and oxidative damage in prefrontal cortex and hippocampus, evaluated by increased lipid peroxidation, carbonyl protein formation and decreased total thiol content. Moreover, ketamine treatment reduced the activity of the antioxidant enzymes superoxide dismutase and catalase in hippocampus. Pretreatment of rats with
C. pachystachya
aqueous extract (200 and 400 mg/kg p.o., for 14 days) or with lithium chloride (45 mg/kg p.o., for 14 days, used as a positive control) prevented both behavioral and pro-oxidant effects of ketamine. These findings suggest that
C. pachystachya
might be a useful tool for preventive intervention in bipolar disorder, reducing the episode relapse and the oxidative damage associated with the manic phase of this disorder .</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/s11064-015-1610-5</identifier><identifier>PMID: 25998886</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Behavior, Animal ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Bipolar Disorder - prevention & control ; Cecropia ; Cell Biology ; Chromatography, High Pressure Liquid ; Female ; Hippocampus - drug effects ; Hippocampus - metabolism ; Ketamine - toxicity ; Locomotion - drug effects ; Neurochemistry ; Neurology ; Neurosciences ; Original Paper ; Oxidative Stress - drug effects ; Plant Extracts - pharmacology ; Prefrontal Cortex - drug effects ; Prefrontal Cortex - metabolism ; Rats ; Rats, Wistar ; Urticaceae - chemistry</subject><ispartof>Neurochemical research, 2015-07, Vol.40 (7), p.1421-1430</ispartof><rights>Springer Science+Business Media New York 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-80f7f2e01cda056c90ba6d892fcc76e7d8b3ef920f03705595da2111cf91b7433</citedby><cites>FETCH-LOGICAL-c438t-80f7f2e01cda056c90ba6d892fcc76e7d8b3ef920f03705595da2111cf91b7433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11064-015-1610-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11064-015-1610-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25998886$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gazal, Marta</creatorcontrib><creatorcontrib>Kaufmann, Fernanda N.</creatorcontrib><creatorcontrib>Acosta, Bruna A.</creatorcontrib><creatorcontrib>Oliveira, Pathise Souto</creatorcontrib><creatorcontrib>Valente, Matheus R.</creatorcontrib><creatorcontrib>Ortmann, Caroline Flach</creatorcontrib><creatorcontrib>Sturbelle, Régis</creatorcontrib><creatorcontrib>Lencina, Claiton L.</creatorcontrib><creatorcontrib>Stefanello, Francieli M.</creatorcontrib><creatorcontrib>Kaster, Manuella P.</creatorcontrib><creatorcontrib>Reginatto, Flávio Henrique</creatorcontrib><creatorcontrib>Ghisleni, Gabriele</creatorcontrib><title>Preventive Effect of Cecropia pachystachya Against Ketamine-Induced Manic Behavior and Oxidative Stress in Rats</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><addtitle>Neurochem Res</addtitle><description>Cecropia
species are widely used in traditional medicine by its anti-diabetic, anti-hypertensive and anti-inflammatory properties. In the present study, we investigated the neuroprotective and antioxidant effects of the crude aqueous extract from
Cecropia pachystachya
leaves in a rat model of mania induced by ketamine. The results indicated that ketamine treatment (25 mg/kg i.p., for 8 days) induced hyperlocomotion in the open-field test and oxidative damage in prefrontal cortex and hippocampus, evaluated by increased lipid peroxidation, carbonyl protein formation and decreased total thiol content. Moreover, ketamine treatment reduced the activity of the antioxidant enzymes superoxide dismutase and catalase in hippocampus. Pretreatment of rats with
C. pachystachya
aqueous extract (200 and 400 mg/kg p.o., for 14 days) or with lithium chloride (45 mg/kg p.o., for 14 days, used as a positive control) prevented both behavioral and pro-oxidant effects of ketamine. These findings suggest that
C. pachystachya
might be a useful tool for preventive intervention in bipolar disorder, reducing the episode relapse and the oxidative damage associated with the manic phase of this disorder .</description><subject>Animals</subject><subject>Behavior, Animal</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bipolar Disorder - prevention & control</subject><subject>Cecropia</subject><subject>Cell Biology</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Female</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Ketamine - toxicity</subject><subject>Locomotion - drug effects</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Oxidative Stress - drug effects</subject><subject>Plant Extracts - pharmacology</subject><subject>Prefrontal Cortex - drug effects</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Urticaceae - chemistry</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU1vEzEQhi0EoqHwA7ggS1x6WZhZr9f2sUQFKoqK-Dhbjj1uXSXeYO9G9N-zaQpCSIiLfZjnfa3xw9hzhFcIoF5XROi7BlA22CM08gFboFSi6Q2Ih2wBYp4KNHDEntR6AzCnWnzMjlppjNa6X7DhU6Ed5THtiJ_FSH7kQ-RL8mXYJse3zl_f1nF_On565VKuI_9Ao9ukTM15DpOnwD-6nDx_Q9dul4bCXQ788kcK7q71y1ioVp4y_-zG-pQ9im5d6dn9fcy-vT37unzfXFy-O1-eXjS-E3psNEQVWwL0wYHsvYGV64M2bfRe9aSCXgmKpoUIQoGURgbXIqKPBleqE-KYnRx6t2X4PlEd7SZVT-u1yzRM1aICg6rVWv0f7U1negFdN6Mv_0JvhqnkeZE7SkKnjZwpPFDzJ9ZaKNptSRtXbi2C3YuzB3F2Fmf34uw-8-K-eVptKPxO_DI1A-0BqPMoX1H54-l_tv4ERbWiWA</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Gazal, Marta</creator><creator>Kaufmann, Fernanda N.</creator><creator>Acosta, Bruna A.</creator><creator>Oliveira, Pathise Souto</creator><creator>Valente, Matheus R.</creator><creator>Ortmann, Caroline Flach</creator><creator>Sturbelle, Régis</creator><creator>Lencina, Claiton L.</creator><creator>Stefanello, Francieli M.</creator><creator>Kaster, Manuella P.</creator><creator>Reginatto, Flávio Henrique</creator><creator>Ghisleni, Gabriele</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20150701</creationdate><title>Preventive Effect of Cecropia pachystachya Against Ketamine-Induced Manic Behavior and Oxidative Stress in Rats</title><author>Gazal, Marta ; Kaufmann, Fernanda N. ; Acosta, Bruna A. ; Oliveira, Pathise Souto ; Valente, Matheus R. ; Ortmann, Caroline Flach ; Sturbelle, Régis ; Lencina, Claiton L. ; Stefanello, Francieli M. ; Kaster, Manuella P. ; Reginatto, Flávio Henrique ; Ghisleni, Gabriele</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-80f7f2e01cda056c90ba6d892fcc76e7d8b3ef920f03705595da2111cf91b7433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Behavior, Animal</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bipolar Disorder - 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Academic</collection><jtitle>Neurochemical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gazal, Marta</au><au>Kaufmann, Fernanda N.</au><au>Acosta, Bruna A.</au><au>Oliveira, Pathise Souto</au><au>Valente, Matheus R.</au><au>Ortmann, Caroline Flach</au><au>Sturbelle, Régis</au><au>Lencina, Claiton L.</au><au>Stefanello, Francieli M.</au><au>Kaster, Manuella P.</au><au>Reginatto, Flávio Henrique</au><au>Ghisleni, Gabriele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preventive Effect of Cecropia pachystachya Against Ketamine-Induced Manic Behavior and Oxidative Stress in Rats</atitle><jtitle>Neurochemical research</jtitle><stitle>Neurochem Res</stitle><addtitle>Neurochem Res</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>40</volume><issue>7</issue><spage>1421</spage><epage>1430</epage><pages>1421-1430</pages><issn>0364-3190</issn><eissn>1573-6903</eissn><abstract>Cecropia
species are widely used in traditional medicine by its anti-diabetic, anti-hypertensive and anti-inflammatory properties. In the present study, we investigated the neuroprotective and antioxidant effects of the crude aqueous extract from
Cecropia pachystachya
leaves in a rat model of mania induced by ketamine. The results indicated that ketamine treatment (25 mg/kg i.p., for 8 days) induced hyperlocomotion in the open-field test and oxidative damage in prefrontal cortex and hippocampus, evaluated by increased lipid peroxidation, carbonyl protein formation and decreased total thiol content. Moreover, ketamine treatment reduced the activity of the antioxidant enzymes superoxide dismutase and catalase in hippocampus. Pretreatment of rats with
C. pachystachya
aqueous extract (200 and 400 mg/kg p.o., for 14 days) or with lithium chloride (45 mg/kg p.o., for 14 days, used as a positive control) prevented both behavioral and pro-oxidant effects of ketamine. These findings suggest that
C. pachystachya
might be a useful tool for preventive intervention in bipolar disorder, reducing the episode relapse and the oxidative damage associated with the manic phase of this disorder .</abstract><cop>New York</cop><pub>Springer US</pub><pmid>25998886</pmid><doi>10.1007/s11064-015-1610-5</doi><tpages>10</tpages></addata></record> |
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| ispartof | Neurochemical research, 2015-07, Vol.40 (7), p.1421-1430 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Behavior, Animal Biochemistry Biomedical and Life Sciences Biomedicine Bipolar Disorder - prevention & control Cecropia Cell Biology Chromatography, High Pressure Liquid Female Hippocampus - drug effects Hippocampus - metabolism Ketamine - toxicity Locomotion - drug effects Neurochemistry Neurology Neurosciences Original Paper Oxidative Stress - drug effects Plant Extracts - pharmacology Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Rats Rats, Wistar Urticaceae - chemistry |
| title | Preventive Effect of Cecropia pachystachya Against Ketamine-Induced Manic Behavior and Oxidative Stress in Rats |
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