Engineering Escherichia coli coculture systems for the production of biochemical products

Engineering microbial consortia to express complex biosynthetic pathways efficiently for the production of valuable compounds is a promising approach for metabolic engineering and synthetic biology. Here, we report the design, optimization, and scale-up of an Escherichia coli - E. coli coculture tha...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-07, Vol.112 (27), p.8266-8271
Hauptverfasser:	Zhang, Haoran, Brian Pereira, Zhengjun Li, Gregory Stephanopoulos
Format:	Artikel
Sprache:	eng
Schlagworte:	4-hydroxybenzoic acid Bacteriological Techniques - methods Base Sequence BASIC BIOLOGICAL SCIENCES biochemical pathways Biochemistry Bioengineering Biological Sciences Biosynthesis Biosynthetic Pathways - genetics coculture Design optimization E coli Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism glucose Glucose - metabolism Industrial Microbiology - methods Industrial products metabolic engineering Metabolic Engineering - methods Metabolism microbial coculture Molecular Sequence Data muconic acid Parabens - metabolism production technology Reproducibility of Results secretion Sorbic Acid - analogs & derivatives Sorbic Acid - metabolism Synthetic biology Synthetic Biology - methods xylose Xylose - metabolism
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