Multimodal and multifunctional stealth polymer nanospheres for sustained drug delivery

Multimodal and multifunctional stealth polymer nanospheres for sustained drug delivery

We report the preparation of fluorescent and magnetic PMMA nanospheres, and a corresponding PEGylated 'stealth' analogue prepared using a block copolymer. The nanospheres contain encapsulated magnetite nanoparticles and fluorescent BODIPY dyes, including a new such dye with pH-sensitive fl...

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Veröffentlicht in:New journal of chemistry 2012-01, Vol.36 (7), p.1457-1462
Hauptverfasser: Evans, Cameron W., Latter, Melissa J., Ho, Diwei, Peerzade, Saquib Ahmed M. A., Clemons, Tristan D., Fitzgerald, Melinda, Dunlop, Sarah A., Iyer, K. Swaminathan
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container_end_page 1462
container_issue 7
container_start_page 1457
container_title New journal of chemistry
container_volume 36
creator Evans, Cameron W.
Latter, Melissa J.
Ho, Diwei
Peerzade, Saquib Ahmed M. A.
Clemons, Tristan D.
Fitzgerald, Melinda
Dunlop, Sarah A.
Iyer, K. Swaminathan
description We report the preparation of fluorescent and magnetic PMMA nanospheres, and a corresponding PEGylated 'stealth' analogue prepared using a block copolymer. The nanospheres contain encapsulated magnetite nanoparticles and fluorescent BODIPY dyes, including a new such dye with pH-sensitive fluorescent emission. The new dye could potentially be used as an indicator of the immediate physiological environment. The nanospheres were non-toxic at up to 500 mu g ml super(-1) in PC12 cells. Lomerizine, a lipophilic calcium channel blocker, was also encapsulated in the nanospheres and displayed sustained, pH-dependent release characteristics. The nanospheres may be of use to release lomerizine and other water-insoluble drugs at central nervous system injury sites.
doi_str_mv 10.1039/c2nj40016b
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title Multimodal and multifunctional stealth polymer nanospheres for sustained drug delivery
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