XRN1 Stalling in the 5' UTR of Hepatitis C Virus and Bovine Viral Diarrhea Virus Is Associated with Dysregulated Host mRNA Stability: e1004708

We demonstrate that both Hepatitis C virus (HCV) and Bovine Viral Diarrhea virus (BVDV) contain regions in their 5' UTRs that stall and repress the enzymatic activity of the cellular 5'-3' exoribonuclease XRN1, resulting in dramatic changes in the stability of cellular mRNAs. We used...

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Veröffentlicht in:	PLoS pathogens 2015-03, Vol.11 (3)
Hauptverfasser:	Moon, Stephanie L, Blackinton, Jeffrey G, Anderson, John R, Dozier, Mary K, Dodd, Benjamin JT, Keene, Jack D, Wilusz, Carol J, Bradrick, Shelton S, Wilusz, Jeffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Bovine viral diarrhea virus Diarrhea Flaviviridae Gene expression Genomes Hepatitis Hepatitis C virus Infections Liver cancer Pathogenesis Proteins Standard deviation
Online-Zugang:	Volltext
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