Neutrophil to Lymphocyte Ratio is Predictor of Atrial Fibrillation Recurrence After Cardioversion With Amiodarone
Background: In this study, our aim is to examine the role of the neutrophil to lymphocyte ratio (NLR) in the predictions of recurrence under long-term follow-up in patients whose sinus rhythms (SRs) were restored with amiodarone in acute atrial fibrillation (AF). Methods: Retrospectively, patients w...
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| Veröffentlicht in: | Clinical and applied thrombosis/hemostasis 2015-01, Vol.21 (1), p.5-9 |
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| creator | Karavelioğlu, Yusuf Karapınar, Hekim Yüksel, Murat Memiç, Kadriye Sarak, Taner Kurt, Recep Yilmaz, Ahmet |
| description | Background:
In this study, our aim is to examine the role of the neutrophil to lymphocyte ratio (NLR) in the predictions of recurrence under long-term follow-up in patients whose sinus rhythms (SRs) were restored with amiodarone in acute atrial fibrillation (AF).
Methods:
Retrospectively, patients with acute AF, which successfully converted to the SR with amiodarone treatment, were recruited into the study. Patients experiencing the first AF attack were enrolled to the study and followed up for 5 years (median 23 months, 25-75 percentiles 12-24 months). Neutrophil to lymphocyte ratio was computed as absolute neutrophil count divided by lymphocyte count.
Results:
A total of 218 patients were recruited into the study and followed up for 21.6 ± 13.9 months; 87 (40%) patients had ≥1 recurrent AF attack within this period. The follow-up of 131 (60%) patients resulted in persisted SR without any other AF attack. Groups were similar in terms of age and gender. Left atrium (LA) diameter and NLR were increased, and platelet count and lymphocyte count were decreased in patients with AF recurrence in univariate analysis (P < .05 for all). Only LA diameter (for per mm, 1.077 [1.021-1.136], P = .006) and NLR (1.584 [1.197-2.095], P = .001) were independent predictors of AF recurrence in the multivariate analysis.
Conclusion:
Increased NLR is a marker of increased inflammation and may serve as simple, cheap, and readily available predictors of recurrence in the long-term follow-up of patients admitted with acute AF and successfully converted to SR with amiodarone. |
| doi_str_mv | 10.1177/1076029613518368 |
| format | Article |
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In this study, our aim is to examine the role of the neutrophil to lymphocyte ratio (NLR) in the predictions of recurrence under long-term follow-up in patients whose sinus rhythms (SRs) were restored with amiodarone in acute atrial fibrillation (AF).
Methods:
Retrospectively, patients with acute AF, which successfully converted to the SR with amiodarone treatment, were recruited into the study. Patients experiencing the first AF attack were enrolled to the study and followed up for 5 years (median 23 months, 25-75 percentiles 12-24 months). Neutrophil to lymphocyte ratio was computed as absolute neutrophil count divided by lymphocyte count.
Results:
A total of 218 patients were recruited into the study and followed up for 21.6 ± 13.9 months; 87 (40%) patients had ≥1 recurrent AF attack within this period. The follow-up of 131 (60%) patients resulted in persisted SR without any other AF attack. Groups were similar in terms of age and gender. Left atrium (LA) diameter and NLR were increased, and platelet count and lymphocyte count were decreased in patients with AF recurrence in univariate analysis (P < .05 for all). Only LA diameter (for per mm, 1.077 [1.021-1.136], P = .006) and NLR (1.584 [1.197-2.095], P = .001) were independent predictors of AF recurrence in the multivariate analysis.
Conclusion:
Increased NLR is a marker of increased inflammation and may serve as simple, cheap, and readily available predictors of recurrence in the long-term follow-up of patients admitted with acute AF and successfully converted to SR with amiodarone.</description><identifier>ISSN: 1076-0296</identifier><identifier>EISSN: 1938-2723</identifier><identifier>DOI: 10.1177/1076029613518368</identifier><identifier>PMID: 24431383</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Aged ; Amiodarone - therapeutic use ; Anti-Arrhythmia Agents - therapeutic use ; Atrial Fibrillation - blood ; Atrial Fibrillation - drug therapy ; C-Reactive Protein - metabolism ; Cardiac arrhythmia ; Female ; Humans ; Inflammation Mediators - blood ; Leukocyte Count ; Logistic Models ; Lymphocytes ; Male ; Middle Aged ; Multivariate Analysis ; Neutrophils ; Predictive Value of Tests ; Recurrence ; Retrospective Studies</subject><ispartof>Clinical and applied thrombosis/hemostasis, 2015-01, Vol.21 (1), p.5-9</ispartof><rights>The Author(s) 2014</rights><rights>The Author(s) 2014.</rights><rights>The Author(s) 2014. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at: https://uk.sagepub.com/en-gb/eur/reusing-open-access-and-sage-choice-content</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-c475ae8754d4e068cfd81f2cf4066d07c7811ceb27d487ebf0f13966a13a56b23</citedby><cites>FETCH-LOGICAL-c398t-c475ae8754d4e068cfd81f2cf4066d07c7811ceb27d487ebf0f13966a13a56b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1076029613518368$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1076029613518368$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21966,27853,27924,27925,44945,45333</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/1076029613518368?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24431383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karavelioğlu, Yusuf</creatorcontrib><creatorcontrib>Karapınar, Hekim</creatorcontrib><creatorcontrib>Yüksel, Murat</creatorcontrib><creatorcontrib>Memiç, Kadriye</creatorcontrib><creatorcontrib>Sarak, Taner</creatorcontrib><creatorcontrib>Kurt, Recep</creatorcontrib><creatorcontrib>Yilmaz, Ahmet</creatorcontrib><title>Neutrophil to Lymphocyte Ratio is Predictor of Atrial Fibrillation Recurrence After Cardioversion With Amiodarone</title><title>Clinical and applied thrombosis/hemostasis</title><addtitle>Clin Appl Thromb Hemost</addtitle><description>Background:
In this study, our aim is to examine the role of the neutrophil to lymphocyte ratio (NLR) in the predictions of recurrence under long-term follow-up in patients whose sinus rhythms (SRs) were restored with amiodarone in acute atrial fibrillation (AF).
Methods:
Retrospectively, patients with acute AF, which successfully converted to the SR with amiodarone treatment, were recruited into the study. Patients experiencing the first AF attack were enrolled to the study and followed up for 5 years (median 23 months, 25-75 percentiles 12-24 months). Neutrophil to lymphocyte ratio was computed as absolute neutrophil count divided by lymphocyte count.
Results:
A total of 218 patients were recruited into the study and followed up for 21.6 ± 13.9 months; 87 (40%) patients had ≥1 recurrent AF attack within this period. The follow-up of 131 (60%) patients resulted in persisted SR without any other AF attack. Groups were similar in terms of age and gender. Left atrium (LA) diameter and NLR were increased, and platelet count and lymphocyte count were decreased in patients with AF recurrence in univariate analysis (P < .05 for all). Only LA diameter (for per mm, 1.077 [1.021-1.136], P = .006) and NLR (1.584 [1.197-2.095], P = .001) were independent predictors of AF recurrence in the multivariate analysis.
Conclusion:
Increased NLR is a marker of increased inflammation and may serve as simple, cheap, and readily available predictors of recurrence in the long-term follow-up of patients admitted with acute AF and successfully converted to SR with amiodarone.</description><subject>Aged</subject><subject>Amiodarone - therapeutic use</subject><subject>Anti-Arrhythmia Agents - therapeutic use</subject><subject>Atrial Fibrillation - blood</subject><subject>Atrial Fibrillation - drug therapy</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiac arrhythmia</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation Mediators - blood</subject><subject>Leukocyte Count</subject><subject>Logistic Models</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neutrophils</subject><subject>Predictive Value of Tests</subject><subject>Recurrence</subject><subject>Retrospective Studies</subject><issn>1076-0296</issn><issn>1938-2723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNkd1rFDEUxYNY7Ie--yQBX3wZm5tk8vG4LFYLi5Wi-DhkMnfclJnJNskI-98761aFgtCnGzi_c26SQ8hrYO8BtL4EphXjVoGowQhlnpEzsMJUXHPxfDkvcnXQT8l5zneMgVVWvSCnXEoBwogzcv8Z55LibhsGWiLd7MfdNvp9QXrrSog0ZPolYRd8iYnGnq5KCm6gV6FNYRgOyERv0c8p4eSRrvqCia5d6kL8iSkf5O-hbOlqDLFzKU74kpz0bsj46mFekG9XH76uP1Wbm4_X69Wm8sKaUnmpa4dG17KTyJTxfWeg576XTKmOaa8NgMeW604ajW3PehBWKQfC1arl4oK8O-buUryfMZdmDNnjcukJ45wb0MyCskY-AVXc_v7kekHfPkLv4pym5SENF1KCBaPZQrEj5VPMOWHf7FIYXdo3wJpDc83j5hbLm4fguR2x-2v4U9UCVEcgux_4b-t_A38BYJegFQ</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Karavelioğlu, Yusuf</creator><creator>Karapınar, Hekim</creator><creator>Yüksel, Murat</creator><creator>Memiç, Kadriye</creator><creator>Sarak, Taner</creator><creator>Kurt, Recep</creator><creator>Yilmaz, Ahmet</creator><general>SAGE Publications</general><general>SAGE PUBLICATIONS, INC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20150101</creationdate><title>Neutrophil to Lymphocyte Ratio is Predictor of Atrial Fibrillation Recurrence After Cardioversion With Amiodarone</title><author>Karavelioğlu, Yusuf ; Karapınar, Hekim ; Yüksel, Murat ; Memiç, Kadriye ; Sarak, Taner ; Kurt, Recep ; Yilmaz, Ahmet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-c475ae8754d4e068cfd81f2cf4066d07c7811ceb27d487ebf0f13966a13a56b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Amiodarone - therapeutic use</topic><topic>Anti-Arrhythmia Agents - therapeutic use</topic><topic>Atrial Fibrillation - blood</topic><topic>Atrial Fibrillation - drug therapy</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiac arrhythmia</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation Mediators - blood</topic><topic>Leukocyte Count</topic><topic>Logistic Models</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neutrophils</topic><topic>Predictive Value of Tests</topic><topic>Recurrence</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karavelioğlu, Yusuf</creatorcontrib><creatorcontrib>Karapınar, Hekim</creatorcontrib><creatorcontrib>Yüksel, Murat</creatorcontrib><creatorcontrib>Memiç, Kadriye</creatorcontrib><creatorcontrib>Sarak, Taner</creatorcontrib><creatorcontrib>Kurt, Recep</creatorcontrib><creatorcontrib>Yilmaz, Ahmet</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Clinical and applied thrombosis/hemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Karavelioğlu, Yusuf</au><au>Karapınar, Hekim</au><au>Yüksel, Murat</au><au>Memiç, Kadriye</au><au>Sarak, Taner</au><au>Kurt, Recep</au><au>Yilmaz, Ahmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neutrophil to Lymphocyte Ratio is Predictor of Atrial Fibrillation Recurrence After Cardioversion With Amiodarone</atitle><jtitle>Clinical and applied thrombosis/hemostasis</jtitle><addtitle>Clin Appl Thromb Hemost</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>21</volume><issue>1</issue><spage>5</spage><epage>9</epage><pages>5-9</pages><issn>1076-0296</issn><eissn>1938-2723</eissn><abstract>Background:
In this study, our aim is to examine the role of the neutrophil to lymphocyte ratio (NLR) in the predictions of recurrence under long-term follow-up in patients whose sinus rhythms (SRs) were restored with amiodarone in acute atrial fibrillation (AF).
Methods:
Retrospectively, patients with acute AF, which successfully converted to the SR with amiodarone treatment, were recruited into the study. Patients experiencing the first AF attack were enrolled to the study and followed up for 5 years (median 23 months, 25-75 percentiles 12-24 months). Neutrophil to lymphocyte ratio was computed as absolute neutrophil count divided by lymphocyte count.
Results:
A total of 218 patients were recruited into the study and followed up for 21.6 ± 13.9 months; 87 (40%) patients had ≥1 recurrent AF attack within this period. The follow-up of 131 (60%) patients resulted in persisted SR without any other AF attack. Groups were similar in terms of age and gender. Left atrium (LA) diameter and NLR were increased, and platelet count and lymphocyte count were decreased in patients with AF recurrence in univariate analysis (P < .05 for all). Only LA diameter (for per mm, 1.077 [1.021-1.136], P = .006) and NLR (1.584 [1.197-2.095], P = .001) were independent predictors of AF recurrence in the multivariate analysis.
Conclusion:
Increased NLR is a marker of increased inflammation and may serve as simple, cheap, and readily available predictors of recurrence in the long-term follow-up of patients admitted with acute AF and successfully converted to SR with amiodarone.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>24431383</pmid><doi>10.1177/1076029613518368</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1076-0296 |
| ispartof | Clinical and applied thrombosis/hemostasis, 2015-01, Vol.21 (1), p.5-9 |
| issn | 1076-0296 1938-2723 |
| language | eng |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Aged Amiodarone - therapeutic use Anti-Arrhythmia Agents - therapeutic use Atrial Fibrillation - blood Atrial Fibrillation - drug therapy C-Reactive Protein - metabolism Cardiac arrhythmia Female Humans Inflammation Mediators - blood Leukocyte Count Logistic Models Lymphocytes Male Middle Aged Multivariate Analysis Neutrophils Predictive Value of Tests Recurrence Retrospective Studies |
| title | Neutrophil to Lymphocyte Ratio is Predictor of Atrial Fibrillation Recurrence After Cardioversion With Amiodarone |
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