Association of the leptin receptor Gln223 Arg polymorphism with lipid profile in obese Pakistani subjects
Abstract Objective Leptin receptor gene ( LEPR ) encodes a receptor for leptin hormone expressed in hypothalamus and single nucleotide polymorphisms in LEPR may have a considerable effect on obesity phenotype. The aim of this study was to investigate an extensively studied LEPR polymorphism Gln223 A...
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| Veröffentlicht in: | Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2015-09, Vol.31 (9), p.1136-1140 |
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| description | Abstract Objective Leptin receptor gene ( LEPR ) encodes a receptor for leptin hormone expressed in hypothalamus and single nucleotide polymorphisms in LEPR may have a considerable effect on obesity phenotype. The aim of this study was to investigate an extensively studied LEPR polymorphism Gln223 Arg in a Pakistani study group and its association patterns with different serum biochemical parameters. Methods The study included 250 obese and 225 nonobese subjects. Gln223 Arg polymorphism was genotyped by polymerase chain reaction restriction fragment-length polymorphism. Anthropometric parameters and plasma glucose, total cholesterol, triacylglycerols, high density lipoprotein cholesterol, low density lipoprotein cholesterol, leptin, and insulin were measured. Results The Gln223 Arg polymorphism was found to be significantly associated with body mass index, systolic and diastolic blood pressure, and weight only in obese subjects, and with all lipid parameters in both obese and nonobese subjects when Gln/Gln or Gln/Arg genotypes were compared with Arg/Arg genotype. Conclusions The LEPR Gln223 is associated with obesity, lipid parameters, and plasma glucose in all subjects, with weight, body mass index, and systolic and diastolic blood pressure only in obese subjects, but showed no association with leptin, insulin, and HOMA-IR in a Pakistani study group. |
| doi_str_mv | 10.1016/j.nut.2015.05.001 |
| format | Article |
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The aim of this study was to investigate an extensively studied LEPR polymorphism Gln223 Arg in a Pakistani study group and its association patterns with different serum biochemical parameters. Methods The study included 250 obese and 225 nonobese subjects. Gln223 Arg polymorphism was genotyped by polymerase chain reaction restriction fragment-length polymorphism. Anthropometric parameters and plasma glucose, total cholesterol, triacylglycerols, high density lipoprotein cholesterol, low density lipoprotein cholesterol, leptin, and insulin were measured. Results The Gln223 Arg polymorphism was found to be significantly associated with body mass index, systolic and diastolic blood pressure, and weight only in obese subjects, and with all lipid parameters in both obese and nonobese subjects when Gln/Gln or Gln/Arg genotypes were compared with Arg/Arg genotype. Conclusions The LEPR Gln223 is associated with obesity, lipid parameters, and plasma glucose in all subjects, with weight, body mass index, and systolic and diastolic blood pressure only in obese subjects, but showed no association with leptin, insulin, and HOMA-IR in a Pakistani study group.</description><identifier>ISSN: 0899-9007</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2015.05.001</identifier><identifier>PMID: 26233872</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Asian Continental Ancestry Group - genetics ; Blood Glucose - metabolism ; Blood Pressure ; Body Mass Index ; Cholesterol ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Female ; Gastroenterology and Hepatology ; Genotype ; Genotypes ; Humans ; Insulin ; Insulin - blood ; Leptin ; Leptin - blood ; Leptin receptor ; Lipid Metabolism - genetics ; Lipid parameters ; Low density lipoprotein ; Male ; Middle Aged ; Obesity ; Obesity - blood ; Obesity - genetics ; Pakistan ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide ; Receptors, Leptin - genetics ; Rodents ; Single nucleotide polymorphism ; Triglycerides - blood</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2015-09, Vol.31 (9), p.1136-1140</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Sep 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-a29f7db442e6e3138ba434e10fc8d75afef9d3119702c5d9a88e6256c572ec2f3</citedby><cites>FETCH-LOGICAL-c469t-a29f7db442e6e3138ba434e10fc8d75afef9d3119702c5d9a88e6256c572ec2f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1702699125?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26233872$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shabana, N.A., M.Phil</creatorcontrib><creatorcontrib>Hasnain, Shahida, Ph.D</creatorcontrib><title>Association of the leptin receptor Gln223 Arg polymorphism with lipid profile in obese Pakistani subjects</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><addtitle>Nutrition</addtitle><description>Abstract Objective Leptin receptor gene ( LEPR ) encodes a receptor for leptin hormone expressed in hypothalamus and single nucleotide polymorphisms in LEPR may have a considerable effect on obesity phenotype. The aim of this study was to investigate an extensively studied LEPR polymorphism Gln223 Arg in a Pakistani study group and its association patterns with different serum biochemical parameters. Methods The study included 250 obese and 225 nonobese subjects. Gln223 Arg polymorphism was genotyped by polymerase chain reaction restriction fragment-length polymorphism. Anthropometric parameters and plasma glucose, total cholesterol, triacylglycerols, high density lipoprotein cholesterol, low density lipoprotein cholesterol, leptin, and insulin were measured. Results The Gln223 Arg polymorphism was found to be significantly associated with body mass index, systolic and diastolic blood pressure, and weight only in obese subjects, and with all lipid parameters in both obese and nonobese subjects when Gln/Gln or Gln/Arg genotypes were compared with Arg/Arg genotype. Conclusions The LEPR Gln223 is associated with obesity, lipid parameters, and plasma glucose in all subjects, with weight, body mass index, and systolic and diastolic blood pressure only in obese subjects, but showed no association with leptin, insulin, and HOMA-IR in a Pakistani study group.</description><subject>Adult</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Blood Glucose - metabolism</subject><subject>Blood Pressure</subject><subject>Body Mass Index</subject><subject>Cholesterol</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Leptin</subject><subject>Leptin - blood</subject><subject>Leptin receptor</subject><subject>Lipid Metabolism - genetics</subject><subject>Lipid parameters</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - genetics</subject><subject>Pakistan</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Receptors, Leptin - genetics</subject><subject>Rodents</subject><subject>Single nucleotide polymorphism</subject><subject>Triglycerides - blood</subject><issn>0899-9007</issn><issn>1873-1244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkk-LFDEQxYMo7uzqB_AiAS9eesyfTrqDIAyLrsKCgnoO6XS1k95Mp03SK_PtTTO7CnsQoSB1-L1HVV4h9IKSLSVUvhm305K3jFCxJaUIfYQ2tG14RVldP0Yb0ipVKUKaM3Se0kgKoaR6is6YZJy3Ddsgt0spWGeyCxMOA857wB7m7CYcwZYmRHzlJ8Y43sUfeA7-eAhx3rt0wL9c3mPvZtfjOYbBecBFFjpIgL-YG5eymRxOSzeCzekZejIYn-D53XuBvn94_-3yY3X9-erT5e66srVUuTJMDU3f1TUDCZzytjM1r4GSwbZ9I8wAg-o5paohzIpembYFyYS0omFg2cAv0OuTb5np5wIp64NLFrw3E4QladoQRaUSQvwPSjmrlaAFffUAHcMSp7LISjGpFGWrIT1RNoaUIgx6ju5g4lFTotfI9KhLZHqNTJNSZHV-eee8dAfo_yjuMyrA2xMA5dduHUSdrIPJQu9KRFn3wf3T_t0DtfVuctb4GzhC-ruFTkwT_XW9mfVkqCCEUSn5b0K1uyE</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Shabana, N.A., M.Phil</creator><creator>Hasnain, Shahida, Ph.D</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150901</creationdate><title>Association of the leptin receptor Gln223 Arg polymorphism with lipid profile in obese Pakistani subjects</title><author>Shabana, N.A., M.Phil ; Hasnain, Shahida, Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-a29f7db442e6e3138ba434e10fc8d75afef9d3119702c5d9a88e6256c572ec2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Blood Glucose - metabolism</topic><topic>Blood Pressure</topic><topic>Body Mass Index</topic><topic>Cholesterol</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Female</topic><topic>Gastroenterology and Hepatology</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Leptin</topic><topic>Leptin - blood</topic><topic>Leptin receptor</topic><topic>Lipid Metabolism - genetics</topic><topic>Lipid parameters</topic><topic>Low density lipoprotein</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - genetics</topic><topic>Pakistan</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Receptors, Leptin - genetics</topic><topic>Rodents</topic><topic>Single nucleotide polymorphism</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shabana, N.A., M.Phil</creatorcontrib><creatorcontrib>Hasnain, Shahida, Ph.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shabana, N.A., M.Phil</au><au>Hasnain, Shahida, Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of the leptin receptor Gln223 Arg polymorphism with lipid profile in obese Pakistani subjects</atitle><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle><addtitle>Nutrition</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>31</volume><issue>9</issue><spage>1136</spage><epage>1140</epage><pages>1136-1140</pages><issn>0899-9007</issn><eissn>1873-1244</eissn><abstract>Abstract Objective Leptin receptor gene ( LEPR ) encodes a receptor for leptin hormone expressed in hypothalamus and single nucleotide polymorphisms in LEPR may have a considerable effect on obesity phenotype. The aim of this study was to investigate an extensively studied LEPR polymorphism Gln223 Arg in a Pakistani study group and its association patterns with different serum biochemical parameters. Methods The study included 250 obese and 225 nonobese subjects. Gln223 Arg polymorphism was genotyped by polymerase chain reaction restriction fragment-length polymorphism. Anthropometric parameters and plasma glucose, total cholesterol, triacylglycerols, high density lipoprotein cholesterol, low density lipoprotein cholesterol, leptin, and insulin were measured. Results The Gln223 Arg polymorphism was found to be significantly associated with body mass index, systolic and diastolic blood pressure, and weight only in obese subjects, and with all lipid parameters in both obese and nonobese subjects when Gln/Gln or Gln/Arg genotypes were compared with Arg/Arg genotype. Conclusions The LEPR Gln223 is associated with obesity, lipid parameters, and plasma glucose in all subjects, with weight, body mass index, and systolic and diastolic blood pressure only in obese subjects, but showed no association with leptin, insulin, and HOMA-IR in a Pakistani study group.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26233872</pmid><doi>10.1016/j.nut.2015.05.001</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Asian Continental Ancestry Group - genetics Blood Glucose - metabolism Blood Pressure Body Mass Index Cholesterol Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Female Gastroenterology and Hepatology Genotype Genotypes Humans Insulin Insulin - blood Leptin Leptin - blood Leptin receptor Lipid Metabolism - genetics Lipid parameters Low density lipoprotein Male Middle Aged Obesity Obesity - blood Obesity - genetics Pakistan Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide Receptors, Leptin - genetics Rodents Single nucleotide polymorphism Triglycerides - blood |
| title | Association of the leptin receptor Gln223 Arg polymorphism with lipid profile in obese Pakistani subjects |
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