$Analysis of serum protein biomarkers, circulating tumor DNA, and dovitinib activity in patients with tyrosine kinase inhibitor-refractory gastrointestinal stromal tumors$

Analysis of serum protein biomarkers, circulating tumor DNA, and dovitinib activity in patients with tyrosine kinase inhibitor-refractory gastrointestinal stromal tumors

An exploratory translational analysis was conducted as part of a phase II study of dovitinib to assess the relevance of soluble serum proteins and circulating tumor (ct) DNA (ctDNA) as biomarkers in patients with tyrosine kinase inhibitor (TKI)-refractory gastrointestinal stromal tumors (GISTs). Pre...

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Veröffentlicht in:	Annals of oncology 2014-11, Vol.25 (11), p.2272-2277
Hauptverfasser:	Yoo, C., Ryu, M.-H., Na, Y.S., Ryoo, B.-Y., Park, S.R., Kang, Y.-K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents BEAMing Benzimidazoles - administration & dosage Biological and medical sciences biomarker Biomarkers, Tumor - blood circulating tumor DNA Disease-Free Survival DNA, Neoplasm - blood DNA, Neoplasm - genetics dovitinib Female Gastroenterology. Liver. Pancreas. Abdomen gastrointestinal stromal tumor Gastrointestinal Stromal Tumors - blood Gastrointestinal Stromal Tumors - drug therapy Gastrointestinal Stromal Tumors - pathology Humans Male Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplastic Cells, Circulating - pathology Pharmacology. Drug treatments Protein Kinase Inhibitors - administration & dosage Proto-Oncogene Proteins B-raf - blood Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins c-kit - blood Proto-Oncogene Proteins c-kit - genetics Quinolones - administration & dosage Receptor, Platelet-Derived Growth Factor beta - blood Receptor, Platelet-Derived Growth Factor beta - genetics Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors Vascular Endothelial Growth Factor A - blood Vascular Endothelial Growth Factor Receptor-2 - blood
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