Persistence of Autoreactive IgA-Secreting B Cells Despite Multiple Immunosuppressive Medications Including Rituximab

IMPORTANCE: Immunobullous diseases mediated by IgA are often difficult to manage, but to date no mechanism has been proposed. Rituximab is an anti-CD20 monoclonal antibody that has demonstrated good efficacy in the treatment of refractory mucous membrane pemphigoid. However, not all cases of mucous...

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Veröffentlicht in:	JAMA dermatology (Chicago, Ill.) Ill.), 2015-06, Vol.151 (6), p.646-650
Hauptverfasser:	He, Yong, Shimoda, Michiko, Ono, Yoko, Villalobos, Itzel Bustos, Mitra, Anupam, Konia, Thomas, Grando, Sergei A, Zone, John J, Maverakis, Emanual
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antibodies, Monoclonal, Murine-Derived - administration & dosage Antibodies, Monoclonal, Murine-Derived - therapeutic use B-Lymphocytes - immunology Drug Therapy, Combination Flow Cytometry Humans Immunoglobulin A - immunology Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - therapeutic use Male Pemphigoid, Benign Mucous Membrane - drug therapy Pemphigoid, Benign Mucous Membrane - immunology Pemphigoid, Benign Mucous Membrane - physiopathology Plasma Cells - metabolism Rituximab Treatment Failure
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